A5043619532- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Radiation Effects and Dosimetry
- Oral health in cancer treatment
- Sarcoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Medical Image Segmentation Techniques
- CNS Lymphoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Cardiac tumors and thrombi
- Tumors and Oncological Cases
- Advances in Oncology and Radiotherapy
Memorial Sloan Kettering Cancer Center
2020-2024
The University of Texas MD Anderson Cancer Center
2012-2019
University of Chicago
2008-2019
Dana-Farber Cancer Institute
2010-2014
Brigham and Women's Hospital
2009-2012
Harvard University
2009-2012
Dana-Farber Brigham Cancer Center
2010-2012
Radiation Oncology Associates
2005-2011
High cure rates for Hodgkin's lymphoma must be balanced with long-term treatment-related toxicity. Here we report an intensity-modulated radiation therapy (IMRT) technique that achieves adequate target coverage mediastinal disease while minimizing high- and low-dose exposure of critical organs. Treatment plans IMRT conventional anteroposterior-posteroanterior (AP-PA) techniques, comparable the planning volume (PTV), were generated 9 female patients assuming use inclined positioning, daily...
First-order radiomic features, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are associated with disease progression in early-stage classical Hodgkin lymphoma (HL). We hypothesized that a model incorporating first- second-order features would more accurately predict outcome than MTV or TLG alone. assessed whether extracted from baseline PET scans predicted relapsed refractory status cohort of 251 patients stage I-II HL who were managed at tertiary cancer center....
The increased interest in 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) radiation treatment planning the past five years necessitated independent and accurate segmentation of gross tumor volume (GTV) from FDG-PET scans. In some studies oncologist contours GTV based on a computed scan, while incorporating pertinent data PET images. Alternatively, simple threshold, typically 40% maximum intensity, has been employed to differentiate normal tissue, other researchers have...
Accurate clinical target volume (CTV) delineation is essential to ensure proper tumor coverage in radiation therapy. This a particularly difficult task for head-and-neck cancer patients where detailed knowledge of the pathways microscopic spread necessary. paper proposes solution auto-segment these volumes oropharyngeal using two-channel 3D U-Net architecture. The first channel feeds network with patient's CT image providing anatomical context, whereas second provides location and...
Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct disease from other head and neck tumors. This guideline provides evidence-based recommendations on the critical decisions in its curative treatment, including both definitive postoperative radiation therapy (RT) management.
Purpose: To compare the effect of respiration‐induced motion on delivered dose (the interplay effect) for different treatment techniques under realistic clinical conditions. Methods: A flexible resin tumor model was created using rapid prototyping based a computed tomography (CT) image an actual tumor. Twenty micro‐MOSFETs were inserted into and anthropomorphic breathing phantom. Phantom programed trajectory patient. four‐dimensional CT obtained several plans planning systems: Conformal...
Methods that allow online lung tumor tracking during radiotherapy are desirable for a variety of applications have the potential to vastly improve treatment accuracy, dose conformity and sparing healthy tissue. Several publications proposed use an on-board kV x-ray imager assess location treatment. However, there is some concern this strategy may expose patient significant amount additional over course typical In paper we present algorithm utilizes portal machine track tumors. This does not...
Background PET-based texture features have been used to quantify tumor heterogeneity due their predictive power in treatment outcome. We investigated the sensitivity of motion by comparing static (3D) and respiratory-gated (4D) PET imaging. Methods Twenty-six patients (34 lesions) received 3D 4D [18F]FDG-PET scans before chemo-radiotherapy. The acquired data were retrospectively binned into five breathing phases create image sequence. Texture features, including Maximal correlation...
Purpose: To develop an automatic segmentation algorithm integrating imaging information from computed tomography (CT), positron emission (PET), and magnetic resonance (MRI) to delineate target volume in head neck cancer radiotherapy. Methods: Eleven patients with unresectable disease at the tonsil or base of tongue who underwent MRI, CT, PET/CT within two months before start radiotherapy chemoradiotherapy were recruited for study. For each patient, T1‐weighted contrast MRI scans first...
Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients' quality life. Given excellent outcomes human papilloma virus (HPV)-associated OPC and long-term survival these typically young patients, treatment de-intensification aimed at improving survivorship while maintaining disease control now a central concern. The recent implementation magnetic resonance image - guided (MRgRT) systems allows individual...
An increasing number of patients with multiple brain metastases are being treated stereotactic radiosurgery (SRS). Manually identifying and contouring all metastatic lesions is difficult time-consuming, a potential source variability. Hence, we developed 3D deep learning approach for segmenting on MR CT images. Five-hundred eleven SRS were retrospectively identified this study. Prior to radiotherapy, the imaged T1 spoiled-gradient post-Gd (T1 + C) contrast-enhanced (CECT), which...
Abstract Purpose To evaluate the accuracy of surface‐guided radiotherapy (SGRT) in cranial patient setup by direct comparison between optical surface imaging (OSI) and cone‐beam computed tomography (CBCT), before applying SGRT‐only for conventional brain nasopharynx cancer. Methods Materials Using CBCT as reference, SGRT was examined based on 269 patients (415 treatments) treated with frameless stereotactic radiosurgery (SRS) during 2018‐2019. Patients were immobilized customized head molds...
Many devices designed for the purpose of performing patient‐specific IMRT/VMAT QA are commercially available. In this work we report our experience and initial clinical results with ArcCHECK. The ArcCHECK consists a cylindrical array diode detectors measuring entry exit doses. measured result is cumulative dose displayed as 2D matrix. detector requires both an absolute calibration, calibration response, relative to each other. addition calibrations suggested by manufacturer, various tests...
We aim to determine the feasibility and dosimetric benefits of a novel MRI-guided IMRT dose-adaption strategy for human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPC).Patients with locally advanced HPV+ OPC underwent pre-treatment in-treatment MRIs every two weeks using RT immobilization setup. For each patient, plans were created (i.e. standard adaptive). The prescription dose was 2.12 Gy/fx 33 fractions initial PTV. adaptive plans, new PTVadaptive generated...
Patients with brain metastases (BMs) are surviving longer and returning for multiple courses of stereotactic radiosurgery. BMs monitored after radiation follow-up magnetic resonance (MR) imaging every 2-3 months. This study investigated whether it is possible to automatically track on longitudinal quantify the tumor response radiotherapy.The METRO process (MEtastasis Tracking Repeated Observations was developed patient data BMs. A intrapatient registration method T1 MR post-Gd conceived...
Abstract Background Evaluation of treatment response for brain metastases (BMs) following stereotactic radiosurgery (SRS) becomes complex as the number treated BMs increases. This study uses artificial intelligence (AI) to track after SRS and validates its output compared with manual measurements. Methods Patients who received at least one course followed up MRI scans were retrospectively identified. A tool automated detection, segmentation, tracking intracranial on longitudinal imaging,...
Methods for accurate tumor volume segmentation of positron emission tomography (PET) images have been under investigation in recent years partly as a result the increased use PET radiation treatment planning (RTP). None developed automated or semiautomated methods, however, has shown reliable enough to be regarded standard. One reason this is that there no source well characterized and test data evaluating such techniques. The authors constructed digital phantom address need. was created...
Anatomic changes during head and neck radiotherapy can impact dose delivery, necessitate adaptive replanning, indicate patient-specific response to treatment. We have developed an automated system track these through longitudinal MRI scans aid identification clinical intervention. The purpose of this article is describe tracking present results from initial cohort patients.The Automated Watchdog in Adaptive Radiotherapy Environment (AWARE) was process data for patients. AWARE automatically...
Purpose: To investigate the feasibility of utilizing tumor tracks from electronic portal imaging device (EPID) images taken during treatment to verify delivered dose. Methods: The proposed method is based on a computation fluence by planned and motion track for each field. A phantom study was designed assess method. CIRS dynamic thorax utilized with realistic soft resin tumor, modeled after real patient tumor. dose calculated compared direct measurements 15 metal oxide semiconductor field...