A5018801529- Algebraic structures and combinatorial models
- Advanced Combinatorial Mathematics
- Advanced Algebra and Geometry
- Homotopy and Cohomology in Algebraic Topology
- Advanced Topics in Algebra
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Conducting polymers and applications
- Algebraic Geometry and Number Theory
- Geometric and Algebraic Topology
- Cancer survivorship and care
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Advanced DC-DC Converters
- TiO2 Photocatalysis and Solar Cells
- Chalcogenide Semiconductor Thin Films
- Microgrid Control and Optimization
- Advanced Battery Technologies Research
- Optical Coatings and Gratings
- ZnO doping and properties
- Organic Electronics and Photovoltaics
- Biopolymer Synthesis and Applications
- Cancer-related Molecular Pathways
Memorial Sloan Kettering Cancer Center
2021-2024
Sidney Kimmel Comprehensive Cancer Center
2017-2022
Johns Hopkins University
2014-2022
Johns Hopkins Medicine
2017-2022
University of Canterbury
2010-2022
Swarthmore College
2011-2022
Sichuan University
2020
West China Hospital of Sichuan University
2020
Keck Graduate Institute
2020
University of Miami
2010-2019
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected applied multi-omic analyses to paired pre- post-treatment PDAC specimens in a platform neoadjuvant study granulocyte-macrophage colony-stimulating factor-secreting allogeneic vaccine (GVAX) ± nivolumab (anti-programmed cell death protein 1 [PD-1]) uncover sensitivity resistance mechanisms. show that GVAX-induced tertiary...
OBJECTIVE To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS We monitored autoantibodies autoreactive T-cells (using tetramers) performed biopsy. The function of was studied with vitro vivo assays. RESULTS Autoantibodies were present pretransplant persisted on follow-up one patient. They appeared years after transplantation but before the...
The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has potential as treatment strategy. Herein, we developed facile one-pot coprecipitation reaction fabricate cluster-structured nanoparticles (CNPs) assembled Fe3O4 iron chlorophyll (Chl/Fe) photosensitizers. This nanoassembled CNP, theranostic agent, could perform red-NIR fluorescence...
The quality of a Th1 response can be prospective correlate vaccine-mediated protection against certain intracellular pathogens. Using two distinct vaccine platforms, we evaluate the influence interleukin (IL) 10 production on magnitude, quality, and protective capacity CD4+ T cell responses in mouse model Leishmania major infection. Multiparameter flow cytometry was used to delineate interferon (IFN) γ, IL-2, tumor necrosis factor (TNF), IL-10 (or combinations thereof) after vaccination....
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity. Tetrahydrofolate dihydrofolate were the most effective substrates, while 5-substituted folates poor substrates. Most pteroyldiglutamates better substrates than monoglutamates.The human FPGS gene spans 12 kilobases contains 15 exons 14 introns. A single located chromosome region 9q34.1. Four exon 1 variants identified, each of which spliced 2. The variant corresponding isolated...
Two methods have been developed to fabricate spheres with gold caps on selective areas so that the self-assembly of these can be potentially carried out in a controlled fashion. The patterned are further functionalized self-assembled groups, such as DNAs, which allows formation second cap same sphere.
Background Radiation therapy (RT) has the potential to enhance efficacy of immunotherapy, such as checkpoint inhibitors, which dramatically altered landscape treatments for many cancers, but not yet pancreatic ductal adenocarcinoma (PDAC). Our prior studies demonstrated that PD ligand-1 and indoleamine 2,3-dioxygenase 1 (IDO1) were induced on tumor epithelia PDACs following neoadjuvant including RT, suggesting RT may prime PDAC PD-1 blockade antibody (αPD-1) or IDO1 inhibitor (IDO1i)...
The TAO (for thousand-and-one amino acids) protein kinases activate p38 mitogen-activated (MAP) kinase cascades in vitro and cells by phosphorylating the MAP/ERK (MEKs) 3 6. We found that TAO2 activity was increased carbachol heterotrimeric G Gαo could 293 cells. Using dominant interfering mutants, we MEKs 6 TAOs were required for activation or constitutively active mutant GαoQ205L. To explore events downstream of TAOs, effects on ternary complex factors (TCFs) investigated. Transfection...
Purpose Due to the high demand of concrete, significant volume natural resources is required, including virgin aggregates. Many studies have shown that production concrete has one highest CO 2 levels. Although efforts are in place recycle, enormous effects on landfill and wider environment remain. Research suggested importance reusing construction demolition waste such as aggregate for use recycled concrete. However, robust reduction strategies required. There been numerous researches its...
Abstract The use of neoadjuvant chemotherapy or radiation for borderline resectable pancreatic adenocarcinoma ( BL ‐ PDAC ) is increasing. However, the impact and therapy on outcome remains to be elucidated. We performed a retrospective analysis 93 consecutive patients who were diagnosed with primarily followed at Johns Hopkins Hospital between February 2007 December 2012. Among patients, 62% received upfront by chemoradiation, whereas 20% chemoradiation alone 15% alone. Resectability...
Abstract We show that the product in quantum K-ring of a generalized flag manifold $G/P$ involves only finitely many powers Novikov variables. In contrast to previous approaches this finiteness question, we exploit finite difference module structure K-theory. At core proof is bound on asymptotic growth $J$-function, which turn comes from an analysis singularities zastava spaces studied geometric representation theory. An appendix by H. Iritani establishes equivalence between and quadratic...
Telomerase reverse transcriptase (TERT) promoter mutations are prognostic in many cancers and have been observed human papillomavirus (HPV)-negative head neck squamous cell carcinomas (HNSCCs). However, the role of TERT HPV-negative HNSCCs remains poorly understood these cancers, which increased risk for locoregional failure (LRF).We retrospectively identified patients who were diagnosed with HNSCC between July 1, 2004, October 12, 2017, at Memorial Sloan Kettering Cancer Center whose tumors...
The bidirectional DC-DC converters are widely used in the energy storage system (ESS) and DC distribution system. power capacity is limited when converter operated with smooth transfer. In addition, directions of inductor current capacitor voltage cannot change instantaneously. this study, a rapid conversion technique for smoothing accelerating transfer under same specification main components steady state proposed. Moreover, high ratio proposed to overcome commonly low input from renewable...
In this paper a novel reset control synthesis method is proposed: CRONE control, combining robust fractional controller with non-linear to overcome waterbed effect. robustness achieved by creation of constant phase behaviour around bandwidth the use operators, also allowing more freedom in shaping open-loop frequency response. However, being linear it suffers from inevitable trade-off between and performance as result Here introduced design fundamental limitations. new design, advantage...
Abstract Pancreas transplant achieves consistent long‐term euglycemia in type 1 diabetes. Allograft thrombosis (AT) causes the majority of early graft failure. We compared outcomes four anticoagulation regimens administered to 95 simultaneous kidney‐pancreas or isolated pancreas transplanted between 1/1/2015 and 11/20/2018. Early postoperative included following: none, subcutaneous heparin/aspirin, with without dextran, heparin infusion. The were empirically selected based on each surgeon's...
Abstract We compute the Euler characteristic of structure sheaf Brill–Noether locus linear series with special vanishing at up to two marked points. When number $\rho $ is zero, we recover Castelnuovo formula for on a general curve; when =1$, formulas Eisenbud-Harris, Pirola, and Chan–Martín–Pflueger–Teixidor arithmetic genus curve divisors. These computations are obtained as applications new determinantal $K$-theory class certain degeneracy loci. Our also specializes expressions double...
Bidirectional DC–DC converters are key devices in the DC distribution system and energy storage (ESS). It is important to consider safety of elements converter for rapid conversion power direction. Damages may occur power-related components circuit if direction inductor current or capacitor voltage changes instantaneously. To make flow change smoothly quickly, this research proposed a bidirectional with transition technology implemented architecture. The added resonance path based on LC...
Protein refolding is still on trial-and-error basis. Here we describe step-wise dialysis refolding, in which denaturant concentration altered fashion. This technology controls the folding pathway by adjusting concentrations of and other solvent additives to induce sequential or disulfide formation. Keywords: Step-wise arginine, aggregation, antibody fragment,
We compute the Euler characteristic of structure sheaf Brill-Noether locus linear series with special vanishing at up to two marked points. When number $ρ$ is zero, we recover Castelnuovo formula for on a general curve; when $ρ=1$, formulas Eisenbud-Harris, Pirola, and Chan-Martín-Pflueger-Teixidor arithmetic genus curve divisors. These computations are obtained as applications new determinantal K-theory class certain degeneracy loci. Our also specializes expressions double Grothendieck...
We establish a finiteness property of the quantum K-ring complete flag manifold.