A5024957945- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Cancer and Skin Lesions
- Liver Disease Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
Memorial Sloan Kettering Cancer Center
2016-2025
New York University
2022
Novartis (Switzerland)
2022
American Society for Radiation Oncology
2022
Jazz Pharmaceuticals (United States)
2022
Takeda (United States)
2022
University of Pittsburgh Medical Center
2022
MSD K.K. (Japan)
2022
Michigan Medicine
2022
Gangneung Asan Hospital
2022
The diagnosis of myoepithelial (ME) tumors outside salivary glands remains challenging, especially in unusual clinical presentations, such as bone or visceral locations. A few reports have indicated EWSR1 gene rearrangement soft tissue ME tumors, and, one case each, the fusion partner was identified either PBX1 ZNF444. However, larger studies to investigate whether these genetic abnormalities are recurrent restricted locations lacking. Sixty-six mainly from (71%), but also skin, bone, and...
There is continuous debate regarding the optimal classification, prognosis, and treatment of follicular variant papillary thyroid carcinoma (FVPTC). The objective this study was to assess behavior FVPTC, especially its encapsulated form, shed more light on true position in classification scheme well differentiated carcinoma.All patients with adenoma (FTA), (FTC) who were diagnosed between 1980 1995 reviewed reclassified according currently accepted definition FVPTC. tumors separated into...
Abstract Hyalinizing clear‐cell carcinoma (HCCC) is a rare, low‐grade salivary gland tumor with distinctive morphology and pattern of hyalinization as well focal mucinous differentiation. However, histological overlap exists other tumors, such epithelial–myoepithelial (EMCa), myoepithelial carcinoma, mucoepidermoid (MEC). The potential relationship between HCCC its morphological mimics has not been yet investigated at the genetic level. In this study, we conducted molecular analysis for...
BackgroundMammary analogue secretory carcinoma (MASC) is a recently described pathologic entity. We report the case of patient with an initial diagnosis salivary acinic cell later reclassified as MASC after next-generation sequencing revealed ETV6-NTRK3 fusion.Patients and methodsThis alteration was targeted pan-Trk inhibitor entrectinib (Ignyta), which possesses potent in vitro activity against lines containing various NTRK1/2/3 fusions.ResultsA dramatic durable response achieved this...
Intraductal papillary neoplasm of the bile duct (IPNB) is a variant carcinoma characterized by intraductal growth and better outcome compared with more common nodular-sclerosing type. IPNB recognized precursor invasive carcinoma, but its pathogenesis natural history are ill-defined. This study examines clinicopathologic features outcomes IPNB. A consecutive cohort patients cancer (hilar, intrahepatic, or distal) was reviewed, those histologic identified. Histopathologic findings...
Background: Anaplastic thyroid carcinoma (ATC) is nearly always fatal. Large studies on ATC are exceedingly rare. We aimed to study the clinical, genotypic, and histologic characteristics of in largest retrospective cohort date. Methods: Three hundred sixty patients with from two tertiary centers were studied. Molecular testing was performed 126 cases including 107 using next-generation sequencing. Results: The median patients' age 68 years. Differentiated (DTC) present 208 (58%), most...
PURPOSE Recurrent or metastatic adenoid cystic carcinoma (R/M ACC) is a malignant neoplasm of predominantly salivary gland origin for which effective therapies are lacking. We conducted phase II trial evaluating the multitargeted tyrosine kinase inhibitor lenvatinib in patients with R/M ACC. PATIENTS AND METHODS This study was two-stage minimax design. Patients histologically confirmed ACC any primary site radiographic and/or symptomatic progression were eligible. Any prior therapy allowed...
Abstract Purpose: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which resistant to chemotherapy and has high mortality rates. We investigated the molecular landscape of SDC, focusing on genetic alterations gene expression profiles. Experimental Design: performed whole-exome sequencing, RNA immunohistochemical analyses in 16 SDC tumors examined selected via targeted sequencing 410 genes a second cohort 15 SDCs. Results: SDCs harbored higher mutational burden than many...
BACKGROUND. Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to lack active systemic therapies. To improve outcomes, deeper understanding genetic alterations vulnerabilities R/M tumors needed.
PURPOSE Standard curative-intent chemoradiotherapy for human papillomavirus (HPV)–related oropharyngeal carcinoma results in significant toxicity. Since hypoxic tumors are radioresistant, we posited that the aerobic state of a tumor could identify patients eligible de-escalation while maintaining treatment efficacy. METHODS We enrolled with HPV-related to receive de-escalated definitive phase II study (ClinicalTrials.gov identifier: NCT03323463 ). Patients first underwent surgical removal...
ABSTRACT Background An objective definition of clinically relevant extracapsular nodal spread (ECS) in head and neck squamous cell carcinoma (SCC) is unavailable. Methods Pathologic review 245 pathologically positive oral cavity SCC dissection specimens was performed. The presence/absence ECS, its extent (in millimeters), multiple primary tumor risk factors were related to disease‐specific survival (DSS) at a follow‐up 73 months. Results ECS detected 109 patients (44%). DSS significantly...
The utility of immunohistochemical detection DNA mismatch repair proteins in screening colorectal cancer for hereditary nonpolyposis (HNPCC) is being widely investigated. Currently, both research and clinical settings, a 4-antibody panel that includes the 4 most commonly affected (MLH1, MSH2, MSH6, PMS2) used generally. On basis biochemical properties these proteins, we hypothesized 2-antibody panel, comprising MSH6 PMS2, would be sufficient to detect abnormalities all proteins. We tested...
Resection of the primary tumor with negative margins is gold standard treatment for squamous cell carcinoma oral tongue (SCCOT). A microscopically positive surgical margin clearly associated a higher risk local recurrence, whereas has traditionally been defined as greater than 5.0 mm clearance from tumor, lesser arbitrarily designated close. The precise cutoff at which recurrence close approximates that remains unclear.To determine whether (<5.0 mm) would portend high after resection...
A subset of cutaneous and superficial soft tissue myoepithelial (ME) tumors displays a distinct ductal component closely resembles mixed tumors/pleomorphic adenomas salivary gland. As PLAG1 HMGA2 rearrangements are the most common genetic events in pleomorphic adenomas, we sought to investigate if these abnormalities also present skin/soft ME lesions. In contrast, half deep‐seated lacking differentiation known be genetically unrelated, showing EWSR1 rearrangements. FISH analysis detect was...
Abstract Background Patients with human papillomavirus–related oropharyngeal cancers have excellent outcomes but experience clinically significant toxicities when treated standard chemoradiotherapy (70 Gy). We hypothesized that functional imaging could identify patients who be safely deescalated to 30 Gy of radiotherapy. Methods In 19 patients, pre- and intratreatment dynamic fluorine-18-labeled fluoromisonidazole positron emission tomography (PET) was used assess tumor hypoxia. without...
Histologic classification of ampullary carcinomas into intestinal, pancreatobiliary, or other subtypes is easily achievable in some cases but difficult others. Immunohistochemical (IHC) stains may allow distinction between the subtypes; however, their added value to routine hematoxylin and eosin (H&E) evaluation has not been systematically evaluated. Inconsistent histologic subtyping hampered current clinical research therapeutic trials. In this study, a consecutive series 105 was subtyped...
Abstract Purpose: Biomarkers for high-grade dysplasia in patients with radiographically identified intraductal papillary mucinous neoplasms (IPMN) have not been described. We hypothesized that IPMN invokes an immunogenic/proinflammatory microenvironment can be by cyst fluid cytokine levels. Experimental Design: Pancreatic aspirates were collected at resection (2005–2009). Samples grouped into low-risk [low-grade (n = 6) or moderate 15)] and high-risk groups [high-grade 13) carcinoma 6)]....