A5100355252- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Leptospirosis research and findings
- Acute Myeloid Leukemia Research
- Plant Gene Expression Analysis
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Plant Molecular Biology Research
- Plant biochemistry and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Plant Stress Responses and Tolerance
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Antioxidant Activity and Oxidative Stress
- Immune cells in cancer
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Spider Taxonomy and Behavior Studies
- Cell Image Analysis Techniques
- Adsorption and Cooling Systems
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
Anhui Academy of Agricultural Sciences
2020-2025
North Sichuan Medical University
2017-2024
Nanchong Central Hospital
2017-2024
Sichuan University
2011-2024
First Hospital of China Medical University
2024
China Medical University
2024
University of South China
2024
Hunan University of Technology
2024
Fujian Agriculture and Forestry University
2024
Southwest Petroleum University
2023-2024
Acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, which generates a PML/RARα fusion protein between PML, growth suppressor localized on nuclear matrix-associated bodies, and RARα, receptor for retinoic acid (RA). was proposed to block myeloid differentiation through inhibition of response, as does dominant negative RARα mutant. In addition, in APL cells, displaces PML other body (NB) antigens onto microspeckles, likely resulting loss and/or NB functions. RA...
Kidney function depends on the nephron, which comprises a blood filter, tubule that is subdivided into functionally distinct segments, and collecting duct. How these regions arise during development poorly understood. The zebrafish pronephros consists of two linear nephrons develop from intermediate mesoderm along length trunk. Here we show that, contrary to current dogma, possess multiple proximal distal domains resemble organization mammalian nephron. We examined whether pronephric...
Summary Apple ( Malus × domestica ) trees are vulnerable to freezing temperatures. However, there has been only limited success in developing cold‐hardy cultivars. This lack of progress is due at least partly understanding the molecular mechanisms tolerance apple. In this study, we evaluated potential roles for two R2R3 MYB transcription factors TF s), 88 and paralogous FLP 124), cold stress apple Arabidopsis . We found that 124 positively regulate cold‐responsive gene expression both...
Costimulatory molecules CD80/CD86 suppress osteoclast differentiation by inducing indoleamine 2,3-dioxygenase.
Acer rubrum is a widespread species valued for its vibrant autumn foliage. The UGT (UDP-glycosyltransferase) gene family integral to the biosynthesis of anthocyanins, pigments responsible leaf coloration. This study aimed comprehensively identify and characterize in A. genome. results phylogenetic analysis 249 ArUGTs revealed 18 distinct subgroups. Conserved motif demonstrated structural similarities within Gene duplication identified 21 tandem 66 segmental events across chromosomes....
The zebrafish kidney marrow is considered to be the organ of definitive hematopoiesis, analogous mammalian bone marrow. We have sequenced 26,143 ESTs and isolated 304 cDNAs with putative full-length ORF from a cDNA library. formed 7,742 assemblies, representing both previously identified (56%) recently discovered (44%). About 30% these EST assemblies orthologues in humans, including 1,282 disease-associated genes Online Mendelian Inheritance Man (OMIM) database. Comparison effective...
Hypoxia-inducible factor (HIF)-1α and HIF-2α are the main regulators of cellular responses to hypoxia. Post-translational modifications HIF-1α 2α necessary modulate their functions. The methylation non-histone proteins by Set7, an SET domain-containing lysine methyltransferase, is a novel regulatory mechanism control cell protein function in response various stresses. In this study, we show that Set7 methylates at 32 K29; inhibits expression HIF-1α/2α targets impairing occupancy HIF-α on...
Abstract ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, using X-ray crystallography SAXS characterization, we demonstrate that tetramerizes through highly conserved PML-specific sequences, which required for NB assembly sumoylation. Conserved...
With the help of Fe3O4 nagnetic nanoparticles as a solid carrier and an excellent tool for separation, six SNP loci (rs2279115 BCL2 gene, rs804270 NEIL2 rs909253 LTA rs2294008 PSCA rs3765524 rs10509670 PLCE1 gene) were selected to evaluate their relation gastric cancer risk. Using two kinds functionalized magnetic universal tagged arrays, whole operation procedure including genome DNA extraction genotyping was performed. All genotypes allele frequencies calculated in cases controls...
Previous studies revealed that the potential tumor suppressor EAF2 binds to and stabilizes pVHL, suggesting may function by disturbing hypoxia signaling pathway. However, extent which affects mechanisms underlying this activity remain largely unknown. In study, we found is a response gene harboring element (HRE) in its promoter. By taking advantage of pVHL-null cell lines RCC4 786-O, demonstrated hypoxia-induced factor 1α (HIF-1α), but not HIF-2α, induced under hypoxia. Subsequent...
Previous studies demonstrated that in vitro the protein kinase TAO2 activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP c-Jun N-terminal kinase/stress-activated (JNK/SAPK). In this study, we examined ability of to activate stress-sensitive pathways cells relationship between activation potential downstream pathways. Over-expression activated endogenous JNK/SAPK but not ERK1/2. Cotransfection experiments suggested selectively MEK3 MEK6 MEKs 1, or 7....
Dorsal organizer formation is one of the most critical steps in early embryonic development. Several genes and signaling pathways that positively regulate dorsal development have been identified; however, little known about factor(s) negatively regulates formation. Here, we show Setdb2, a SET domain-containing protein possessing potential histone H3K9 methyltransferase activity, restricts left–right asymmetry by suppressing fibroblast growth factor 8 ( fgf8 ) expression. Knockdown Setdb2...
Early detection of breast cancer (BC) is very important to avoid mortality caused by it. It concluded in recent studies that the DNA patient's serum can be used as biomarker for detection. Therefore, extracting high-quality from achieve this goal. In work, we compared three methods (phenol-chloroform, column-based and magnetic beads) means purchased commercial kits kit best one extract Cell-free (cfDNA). Then developed a new named PuriMag beads BC patients. Further, described properties...