A5028424745- DNA Repair Mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Zebrafish Biomedical Research Applications
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Electrocatalysts for Energy Conversion
- Protein Degradation and Inhibitors
- Metabolism, Diabetes, and Cancer
- Carbon Nanotubes in Composites
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Virus-based gene therapy research
Guangzhou Medical University Cancer Hospital
2013-2025
Chongqing Medical University
2013-2025
University of Macau
2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Chinese Academy of Sciences
2010-2024
China Three Gorges University
2018-2024
Scripps (United States)
2023-2024
Scripps Institution of Oceanography
2023-2024
Institute of Genetics and Developmental Biology
2021-2024
Abstract Safety, nontoxicity, and durability directly determine the applicability of essential characteristics lithium (Li)‐ion battery. Particularly, for lithium–sulfur battery, due to low ignition temperature sulfur, metal as anode material, use flammable organic electrolytes, addressing security problems is increased difficulty. In past few years, two basic electrolyte systems are studied extensively solve notorious safety issues. One system conventional liquid electrolyte, other...
Abstract Tumour metastasis, the spread of cancer cells from original tumour site followed by growth secondary tumours at distant organs, is primary cause cancer-related deaths and remains poorly understood. Here we demonstrate that inhibition CDK4/6 blocks breast metastasis in triple-negative model, without affecting growth. Mechanistically, identify a deubiquitinase, DUB3, as target CDK4/6; CDK4/6-mediated activation DUB3 essential to deubiquitinate stabilize SNAIL1, key factor promoting...
BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase. But how this achieved remains unclear. Here, we report that E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD RING finger domains 1) directly participates interplay between 53BP1. Mechanistically, recruited to double-strand breaks (DSBs) by S phase, requires BRCT domain phosphorylated Ser674 UHRF1. Subsequently,...
Tumor-derived extracellular vesicle (TEV) protein biomarkers facilitate cancer diagnosis and prognostic evaluations. However, the lack of reliable convenient quantitative methods for evaluating TEV proteins prevents their clinical application. Methods: Here, based on dual amplification hybridization chain reaction (HCR) CRISPR-Cas12a, we developed apta-HCR-CRISPR assay direct high-sensitivity detection proteins. The protein-targeted aptamer was amplified by HCR to produce a long-repeated...
Overexpression of hypoxia-induced factor 1α (HIF-1α) has been shown to be involved in the development and progression hepatocellular carcinoma (HCC). HIF-1α should therefore a promising molecular target for anti-HCC agents. Metformin, an established antidiabetic drug, proved also effective treating cancer although precise underlying mechanisms this activity are not fully elucidated. The aim study was investigate effects metformin on expression oxygen metabolism HCC. results showed that...
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated 80 (RAP80) helps recruit to double-strand breaks (DSBs) through the scaffold CCDC98 (Abraxas) facilitates damage response (DDR). However, of RAP80-BRCA1 complex is still unclear. Here we report a deubiquitinase, USP13, DDR by targeting RAP80. Mechanistically, USP13...
The excellent photocatalytic activity of Zn<sub>0.8</sub>Cd<sub>0.2</sub>S@g-C<sub>3</sub>N<sub>4</sub> heterojunctions is ascribed to the synergetic effects twinned homojunctions and core–shell structures.
Immune checkpoint blockade (ICB) has revolutionized cancer therapy. However, the response of patients to ICB is difficult predict. Here, we examined 81 with lung under treatment and found that MET amplification were resistant had a poor progression-free survival. Tumors amplifications significantly decreased STING levels antitumor T-cell infiltration. Furthermore, performed deep single-cell RNA sequencing on more than 20,000 single immune cells identified an immunosuppressive signature...
The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic acids. enzymatic transamination cycles that are key modern biochemical formation enantiopure may have evolved from this half the reversible reaction couple. Kinetic precursors emerges as general enantioenrichment under prebiotic conditions.