A5052314318- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- RNA modifications and cancer
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bioactive Natural Diterpenoids Research
- Cell death mechanisms and regulation
- Lymphoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Ion Transport and Channel Regulation
- interferon and immune responses
- Zebrafish Biomedical Research Applications
- CRISPR and Genetic Engineering
- Genetically Modified Organisms Research
- Eosinophilic Disorders and Syndromes
- Cerebrovascular and Carotid Artery Diseases
- Magnesium in Health and Disease
- Autophagy in Disease and Therapy
China Pharmaceutical University
2024
Huangshi Central Hospital
2011-2024
Hubei Polytechnic University
2022-2024
National Human Genome Research Institute
2015-2023
National Institutes of Health
2014-2022
Tianjin Medical University
2020
Shanghai Jiao Tong University
2012-2018
Ruijin Hospital
2012-2018
Shanghai Institute of Hematology
2009-2018
Shanghai Institutes for Biological Sciences
2003-2013
Oridonin treats AML by generating a truncated version of the AML1-ETO oncoprotein that functions as tumor suppressor.
Eriocalyxin B (EriB), a diterpenoid isolated from Isodon eriocalyx , was previously reported to have antitumor effects via multiple pathways, and these pathways are related immune responses. In this study, we demonstrated that EriB efficacious in experimental autoimmune encephalomyelitis (EAE), an animal model for sclerosis. Treatment with led amelioration of EAE, which correlated reduced spinal cord inflammation demyelination. treatment abolished encephalitogenic T-cell responses myelin...
Abstract ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, using X-ray crystallography SAXS characterization, we demonstrate that tetramerizes through highly conserved PML-specific sequences, which required for NB assembly sumoylation. Conserved...
Significance Somatic mutations in some splicing factor genes are frequently found myelodysplastic syndromes (MDS) and MDS-related acute myeloid leukemia (AML), blood cancers with few effective treatment options. However, the pathophysiological effects of these remain poorly characterized. Here, we report establishment mouse models to study a common mutation, U2AF1 (S34F). Production mutant protein murine hematopoietic compartment disrupts hematopoiesis ways resembling human MDS. We further...
The boronic acid dipeptide bortezomib inhibits the chymotrypsin-like activity of 26S proteasome and shows significant therapeutic efficacy in multiple myeloma. However, recent studies suggest that may have more complex mechanisms action treating cancer. We report here endocytosis lysosomal degradation receptor tyrosine kinase C-KIT are required for bortezomib- but not inhibitor imatinib-caused apoptosis t (8;21) leukemia gastrointestinal stromal tumor cells, suggesting recruit an initiator....
RUNX1 is essential for the generation of hematopoietic stem cells (HSCs). Runx1-null mouse embryos lack definitive hematopoiesis and die in mid-gestation. However, although zebrafish with a runx1 W84X mutation have defects early hematopoiesis, some runx1W84X/W84X can develop to fertile adults blood multilineages, raising possibility that HSCs emerge without RUNX1. Here, using 3 new runx1-/- lines, we uncovered compensatory mechanism runx1-independent hematopoiesis. We show that, absence...
Abstract Background Octamer-binding transcription factor 4-positive circulating tumor cell (OCT4 + CTC) exhibits high stemness and invasive potential, which may influence the efficacy of immune checkpoint inhibitors (ICI). This study aimed to assess prognostic role OCT4 CTC in advanced cholangiocarcinoma (CCA) patients who received ICI treatment. Methods In total, 40 CCA treatment were included, counts detected via a Canpatrol system an RNA situ hybridization method before Patients...
MicroRNAs (miRNAs/miRs) are crucial regulatory molecules that act as the most significantly downregulated microRNAs in hepatocellular carcinoma (HCC). PTK2b/Pyk2 is a non-receptor protein tyrosine kinase, which plays an important role development and metastasis of cancer. In this study, we explored expression level functional relationship between MicroRNA-214 (miR-214) PTK2b/ Pyk2 liver cancer cells. For purpose, analyzed miR-214 38 cases HCC paired non-neoplastic tissue specimens using...
AbstractWe identified and characterised the cDNA coding for human Lag3, a member of novel eukaryotic Lag1 protein family which was related to Saccharomyces cerevisiae longevity-assurance gene LAG1. The composite nucleotide sequence revealed region 1140 bp, 5'-UTR 210 bp 3'-UTR 900 bp. deduced 380 amino acids had six transmembrane regions conserved motif. Northern blot analysis that ~2.2 kb LAG3Hs transcript expressed in all 12 tissues, high kidney liver, moderate brain, heart, skeletal...
// Xianyu Zhang 1 , Ying Lu Xin Cao 2 Tao Zhen 3 and Damian Kovalovsky Experimental Immunology Branch, NCI, NIH, Maryland, USA College of Life Science Engineering, Northwest University for Nationalities, Gansu Engineering Research Center Animal Cell, Lanzhou, China Oncogenesis Development Section, National Human Genome Institute, Correspondence to: Kovalovsky, email: Keywords : Zbtb1, lymphoid, development, myeloid, differentiation, Microbiology Immune response, Immunity Received June 18,...
From the dried flower-buds of Panax ginseng C.A. Meyer, a new minor dammarane-type triterpene saponin named ginsenoside III together with nine known saponins was isolated. On basis spectral and chemical evidence, structure elucidated as 3-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-20-O-beta- D-glucopyranosyl-3 beta,12 beta,20(S)-trihydroxy-dammar-25-en-24-one.
ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2) is an essential splicing factor involved in 3' splice-site recognition as a component of both the major minor spliceosomes that mediate U2-type (major) U12-type (minor) introns, respectively. Studies ZRSR2-depleted cell lines ZRSR2-mutated patient samples revealed its role U12-dependent spliceosome. However, during embryonic development not clear, function compensated for by Zrsr1 mice. Here, we utilized zebrafish...