A5102004264- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Advanced Radiotherapy Techniques
- Cytokine Signaling Pathways and Interactions
- Biochemical and Molecular Research
- Ferroptosis and cancer prognosis
- Additive Manufacturing Materials and Processes
- Adenosine and Purinergic Signaling
- Cytomegalovirus and herpesvirus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Melanoma and MAPK Pathways
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Sun Yat-sen University
2012-2024
Yichang Central People's Hospital
2022-2024
China Three Gorges University
2024
China Medical University
2023
Sun Yat-sen University Cancer Center
2012-2021
State Key Laboratory of Oncology in South China
2019-2021
Meizhou City People's Hospital
2021
Qilu Hospital of Shandong University
2021
Harvard University
2019
Dysregulation of non-coding RNAs, including miRNAs and lncRNAs has been reported to play vital roles in gastric cancer (GC) carcinogenesis, but the mechanism involved is largely unknown. Using genome atlas (TCGA) data set bioinformatics analyses, we identified miR-532-5p as a potential tumor suppressor GC, found that lncRNA LINC01410 might be negative regulator miR-532-5p. We then conducted series vivo vitro assays explore effect on miR-532-5p-mediated GC malignancy underlying involved....
// Peng Sun 1, 2, * , Fei Zhang Cui Chen 3, Xiwen Bi 2 Hang Yang Xin An Fenghua Wang Wenqi Jiang 1 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong Province 510060, P. R. China Department Medical Oncology, Yat-Sen University Center, 3 The First Affiliated Hospital, University, 510080, These authors have contributed equally to this work Correspondence to: Wang, email: wangfh@sysucc.org.cn Jiang, jiangwq@sysucc.org.cn...
Abstract Background The development of chemoresistance and metastasis are the leading causes death for gastric cancer (GC) patients, however, molecular mechanisms involved remain unclear. Dysregulation miRNAs is associated with a variety disease, including GC. Recently, microarray profiling analysis revealed that miR-939 was dysregulated in human GC samples, but role has not been intensively investigated. Methods In present study, we firstly examined expression pattern two independent...
We previously reported the oncogenic role of paired-like homeodomain 2 (PITX2) in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to identify miRNA regulators PITX2 and mechanism underlying pathogenesis ESCC.Using profiling bioinformatics analyses, identified miR-644a as a negative mediator ESCC. A series vivo vitro assays were performed confirm effect on PITX2-mediated ESCC malignancy.ESCC cells tissues expressed less than normal epithelial controls. patient samples,...
Background: Myocardial fibrosis predicts adverse outcomes in myocardial infarction (MI) and other cardiovascular conditions. Cardiovascular magnetic resonance (CMR) can non-invasively detect focal diffuse fibrosis, but comprehensive validation against histology remains scarce. Aims: To assess the comparative diagnostic performance of CMR methods detecting using a mini-swine model as gold standard. Methods: Eighteen (16 MI; 2 healthy) underwent cine, LGE, T1- ECV-mapping. Two commonly-used...
The Albumin-to-Alkaline Phosphatase Ratio (AAPR) has been recently revealed as a prognostic index for hepatocellular carcinoma, whereas its role in metastatic nasopharyngeal cancer (NPC) remains unclear.The aim of this study was to evaluate the clinical value AAPR patients with NPC.We retrospectively reviewed 209 NPC treated cisplatin-based regimens.Survival data were calculated using Kaplan-Meier method and compared log-rank test.Univariate multivariate survival analyses conducted Cox...
The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear metastatic nasopharyngeal carcinoma (NPC). current study retrospectively analyzed 148 patients with NPC who underwent cisplatin-based chemotherapy and further evaluated the value of CRP/Alb association clinical characteristics these patients. optimal cut-off was 0.189 for ratio. high significantly associated elevated NLR,...
Background: Malignant lymphomas are a group of distinct lymphoid neoplasms, exhibiting marked diversity in biological behaviors and clinical outcomes.Liquid biopsy, such as circulating cell-free DNA (cfDNA), has recently been attempted to be used for mutation profiling using next-generation sequencing (NGS).However, only limited data about cfDNA restricted Hodgkin's lymphoma B cell lymphoma, there is no report the T so far.Patient Methods: Medical records total 50 patients were...
Background Several inflammation-based prognostic scoring systems, including Glasgow Prognostic Score (GPS), neutrophil to lymphocyte ratio (NLR) and platelet (PLR) have been reported predict survival in many malignancies, whereas their role metastatic nasopharyngeal carcinoma (NPC) remains unclear. The aim of this study is evaluate the clinical value these systems a cohort cisplatin-based treated patients with NPC. Methods Two hundred eleven histologically proven NPC first-line chemotherapy...
// Jia-Xing Zhang 1, 2, * , Miao Yun 3, Yi Xu Jie-Wei Chen 4 Hui-Wen Weng 1 Zou-San Zheng Cui Dan Xie 2 Sheng Ye Department of Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, 3 Ultrasound, Pathology, These authors contributed equally to this work Correspondence to: Sheng, e-mail: yes20111212@163.com Xie, xiedan@sysucc.org.cn Keywords:...
Nutritional evaluation is important for patients with esophageal cancer, but the impact of undernutrition on outcome those not well elucidated. Our aim to assess baseline nutritional status overall survival (OS) in Chinese squamous cell carcinoma (ESCC) and detect a most appropriate indicator evaluation.502 from Southern China diagnosed as ESCC Sun Yat-Sen University Cancer Center were included. A series indicators introduced evaluate status. Kaplan-Meier method was used estimate 5-year OS...
Abstract Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression its clinical significance nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR immunohistochemistry were employed evaluate NPC cell lines tissues. In our study, elevated was observed at both protein mRNA levels than NPEC2 Bmi-1. markedly higher tissues adjacent non-tumorous...
Background: In this study, we investigated the functional correlation between microRNA-210 (miR-210) and gene of F-box protein 31 (FBXO31) in regulating breast cancer. Methods: Dual-luciferase assay quantitative real-time polymerase chain reaction were used to investigate binding miR-210 with FBXO31 their expression patterns was inhibited cancer T47D MCF-7 cells assess its effect on proliferation, cell cycle progression, migration. also downregulated examine miR-210-mediated regulation. The...
The association between clinical characteristics, prognosis, and the ABO blood group of esophageal squamous cell carcinoma (ESCC) is rarely discussed. aims current study were to investigate correlation with clinicopathological characteristics in a consecutive cohort patients ESCC assess whether was associated prognosis. A total 511 locoregional who underwent curative treatment retrospectively analyzed at single institution January 2007 December 2008. relationship variables assessed by...
Abstract Solute carrier family 34 member 2 (SLC34A2), a pH-sensitive sodium-dependent phosphate transporter, is associated with several human cancers. In this study, we investigate the clinical significance of SLC34A2 and its function in bladder cancer (BC). The expression dynamics were examined two independent cohorts BC samples by quantitative PCR, western blotting immunohistochemical staining. training cohort (156 cases), applied X-tile program software to assess optimal cutoff points for...
Asparaginase/pegaspargase containing regimens combined with radiotherapy are highly effective and considered the cornerstone of localized Natural killer/T-cell lymphoma (NKTL) treatment. However, these chemotherapy inevitably cause relatively high incidence treatment-related adverse events (TRAEs). Herein we retrospectively evaluated efficacy safety regimen anti-PD-1 antibody, anlotinib pegaspargase "sandwich" in NKTL. Anti-PD-1 antibody at 2500 U/m2 were administered on day 1, while (12 mg...
Abstract Guanine nucleotide binding protein alpha 13 (GNA13) has been found to play critical roles in the development of several human cancers. However, little is known about GNA13 expression and its clinical significance hepatocellular carcinoma (HCC). In our study, was reported be significantly up-regulated HCC tissues, this correlated with clinicopathological parameters, including tumor multiplicity (P = 0.004), TNM stage 0.002), BCLC 0.010). Further Cox regression analysis suggested that...
Abstract Background Metastasis remains the main cause of cancer-related death for gastric cancer (GC) patients, but mechanisms are poorly understood. Using The Cancer Genome Atlas (TCGA) data base and bioinformatics analyses, we identified C12orf59 might act as a potential oncogenic protein in GC. Methods We investigate expression pattern clinical significance two independent cohorts GC samples. In training cohort, used X-tile program software to generate optimal cutoff value order classify...