A5100756122- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Liver Disease and Transplantation
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- HER2/EGFR in Cancer Research
- Gut microbiota and health
- interferon and immune responses
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Cervical Cancer and HPV Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Inflammasome and immune disorders
- Flavonoids in Medical Research
- Acute Ischemic Stroke Management
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2017-2025
Huazhong University of Science and Technology
2014-2025
Shanxi Medical University
2012-2025
Central Hospital of Wuhan
2024-2025
Peking University People's Hospital
2025
Peking University
2025
Shanghai University of Traditional Chinese Medicine
2025
Shanxi Academy of Medical Sciences
2025
Chinese Institute for Brain Research
2022-2024
Abstract Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during fusion of MVEs with cell membrane. The mechanisms exosome biogenesis remain poorly explored. Here we identify that RAB31 marks controls an ESCRT-independent pathway. Active RAB31, phosphorylated by epidermal growth factor receptor (EGFR), engages flotillin proteins in lipid raft microdomains to drive EGFR entry into form ILVs, which is independent ESCRT (endosomal...
Extreme weather events can cause heat stress that decreases crop production. Recent studies have demonstrated protein degradation and rRNA homeostasis as well transcription factors are involved in the thermoresponse plants. However, how RNA modifications contribute to temperature response plant remains largely unknown. Herein, we identified OsNSUN2 an 5-methylcytosine (m5C) methyltransferase rice. osnsun2 mutant displayed severe temperature- light-dependent lesion-mimic phenotypes...
Abstract STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical Mechanistically, RAB22A engages PI4K2A generate PI4P recruits the Atg12–Atg5–Atg16L1 complex, inducing formation of ER-derived autophagosome, in which agonists or...
Thyroid cancer is a highly differentiated and poorly malignant tumor. Interfering with glycolysis has become an effective means of controlling progression autophagy negatively correlated glycolysis. Aldo-keto reductase family 1 member C3 (AKR1C3) been demonstrated to be expressed in thyroid tissue the higher AKR1C3 expression predicted worse prognosis. We aimed explore whether could affect by regulating autophagy-dependent cells was detected western blot. Then, knocked down transfection...
Abstract Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine kinase. We showed that the expression of GSK3β was drastically down-regulated in human cutaneous squamous cell carcinomas and basal carcinomas. Due to its negative regulation many oncogenic proteins, we hypothesized may function as tumor suppressor during neoplastic transformation epidermal cells. tested this hypothesis using an vitro model system, JB6 mouse In response growth factor (EGF) or...
The DNA repair pathways help to maintain genomic integrity and therefore genetic variation in the could affect propensity develop cancer. Selected germline single nucleotide polymorphisms (SNPs) have been associated with esophageal cancer gastric (GC) but few studies comprehensively examined pathway genes. We aimed investigate associations between genes risk of squamous cell carcinoma (ESCC) GC, using data from a genome-wide association study Han Chinese population where ESCC GC are...
Abstract Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects B-ALL post received CAR-T were analyzed. 34 (79%; 95% confidence interval [CI]: 66, 92%) achieved complete histological remission (CR). Cytokine release syndrome (CRS) occurred 38 (88%; 78, 98%) was ≥grade-3 7. Two died from multiorgan failure CRS....
Intracellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) depends on the interaction between its spike protein with cellular receptor angiotensin-converting enzyme (ACE2) and Furin-mediated cleavage priming by host cell proteases, including transmembrane protease serine (TMPRSS2). As expression ACE2, TMPRSS2, Furin in middle inner ear remain unclear, we analyzed these proteins mouse tissues.Animal Research.We performed immunohistochemical analysis to examine...
Background: Nanovaccines have emerged as a promising vaccination strategy, exhibiting their capacity to deliver antigens and adjuvants elicit specific immune responses. Despite this potential, optimizing the design delivery of nanovaccines remains challenge. Methods: In study, we engineered dendritic mesoporous silica-based nanocarrier enveloped in metal-phenolic network (MPN) layer containing divalent manganese ions tannic acid (MSN@MT). This was tailored for antigen loading serve...
Abstract Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes. Canonical autophagy requires all (ATGs), whereas noncanonical activated diverse agents some of essential are dispensable. How induced and/or inhibited still largely unclear. In this study, we demonstrated that AMDE-1, a recently identified chemical can induce canonical autophagy, was able to elicit independent ULK1 (unc-51-like kinase 1) complex...
Distant metastasis remains the leading cause of treatment failure in patients with nasopharyngeal carcinoma (NPC), making it critical to identify efficient therapeutic targets for metastatic NPC. Previous studies have demonstrated that deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) is associated development various types cancer. However, its role and mechanism NPC not been explored.RNA-seq profiling was performed three pairs normal nasopharynx tissues. DNTTIP1...
Immune checkpoint inhibitor-induced type 1 diabetes (ICI-T1D) is a rare immune-related adverse event (irAE) of immune inhibitors (ICIs). This retrospective study aimed to characterize the clinical features and glucose patterns ICI-T1D in Chinese individuals compare them with those traditional T1D. Between January 2019 April 2024, 15 patients diagnosed were consecutively enrolled. Continuous monitoring (CGM) data from 7 these compared 14 T1D patients, matched for age, sex, fasting C-peptide...