A5037413259- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Smoking Behavior and Cessation
- Obesity, Physical Activity, Diet
- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Scientific Computing and Data Management
- Lung Cancer Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Research Data Management Practices
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
Information Management Services
2013-2024
National Heart Lung and Blood Institute
2017
Murphy Oil Corporation (United States)
2016
National Cancer Institute
1998-2015
Cancer Genetics (United States)
2015
University College London
2015
Division of Cancer Epidemiology and Genetics
2006-2015
Fred Hutch Cancer Center
2012
Associated Management Services (United States)
1996-2011
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2011
Previous studies that showed an association between smoking and adenocarcinomas of the esophagus esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, duration cigarette cessation.We used primary data from 10 population-based case-control two cohort Barrett's Esophagus Esophageal Adenocarcinoma Consortium. Analyses restricted white non-Hispanic men women. Patients classified as having esophageal adenocarcinoma (n = 1540), junctional...
Abstract Purpose: Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with poor prognosis. Understanding molecular changes in ESCC will enable identification of subtypes and provide potential targets for early detection therapy. Experimental Design: We followed up a previous array study additional discovery confirmatory studies new cases by using alternative methods. profiled global gene expression confirmation, validated selected dysregulated genes RNA protein studies. Results:...
Background: Alcohol ingestion is associated with an increased risk of breast cancer in most epidemiologic studies. Results, however, are heterogeneous at lower levels alcohol intake, and a biologic mechanism for the association has not been clearly identified. To determine whether consumption by postmenopausal women elevates serum hormones cancer, we performed controlled feeding study. Methods: Participants were 51 healthy using hormone replacement therapy. Each participant rotated through...
Cigarette smoking has been implicated in the etiology of esophageal adenocarcinoma, but it is not clear if a risk factor for Barrett's esophagus. We investigated whether tobacco and other factors increase esophagus.We analyzed data from 5 case-control studies included international Esophageal Adenocarcinoma Consortium. compared subjects with esophagus (n = 1059) those gastroesophageal reflux disease (gastroesophageal controls, n 1332), population-based controls 1143), using multivariable...
Objective To profile RNA expression in gastric cancer by anatomic subsites as an initial step identifying molecular subtypes and providing targets for early detection therapy. Methods We performed transcriptome analysis using the Affymetrix GeneChip U133A cardia adenocarcinomas (n = 62) noncardia 72) their matched normal tissues from patients Shanxi Province, validated selected dysregulated genes with additional studies. Expression of was also related to survival cases. Results Principal...
Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the cardia versus non-cardia.Here we present results a GWAS using 2350 East Asian cases as 1189 and 1027 non-cardia 2708 controls. We also included up to 3042 cases, 4359 7548 controls replication from two Chinese one Korean study. From GWAS, selected 12 top SNPs each subtype, 4 total 1 SNP MUC1...
Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma 316 non-cardia 1514 age-, gender-, neighborhood-matched controls were asked for FH in first degree relatives non-blood relatives. Odds ratios (ORs) 95% confidence intervals (CIs) from logistic regressions, hazard (HRs) Cox proportional...
The DNA repair pathways help to maintain genomic integrity and therefore genetic variation in the could affect propensity develop cancer. Selected germline single nucleotide polymorphisms (SNPs) have been associated with esophageal cancer gastric (GC) but few studies comprehensively examined pathway genes. We aimed investigate associations between genes risk of squamous cell carcinoma (ESCC) GC, using data from a genome-wide association study Han Chinese population where ESCC GC are...
Abstract Gastric cancer and esophageal are the second sixth leading causes of cancer-related death worldwide. Multiple genomic alterations underlying gastric squamous cell carcinoma (ESCC) have been identified, but full spectrum structural variations mutations yet to be uncovered. Here, we report results whole-genome sequencing 30 samples comprising tumor blood from 15 patients, four whom presented with ESCC, seven cardia adenocarcinoma (GCA), noncardia adenocarcinoma. Analyses revealed that...
The National Heart, Lung, and Blood Institute (NHLBI), within the United States' Institutes of Health (NIH), established a Biorepository in 1976 that initially archived biospecimens from population-based blood product safety surveys. It was later expanded to clinical epidemiological studies heart, lung, disorders. NHLBI also Data Repository 2000 store distribute study data NHLBI-sponsored research. Biologic Specimen Information Coordinating Center (BioLINCC) 2008 develop infrastructure...
Research on data sharing from clinical trials has focused elucidating perceptions, barriers, and attitudes among trialists study participants with respect to data. However, little information exists regarding utilization or associated publication of articles once trial have been widely shared.We analyzed administrative records investigator requests for access, linked publications, bibliometrics describe the use National Heart, Lung, Blood Institute repository.From January 2000 through May...
Abstract Whole genome association studies of complex human diseases represent a new paradigm in the postgenomic era. In this study, we report application Affymetrix, Inc. (Santa Clara, CA) high-density single nucleotide polymorphism (SNP) array containing 11,555 SNPs pilot case-control study esophageal squamous cell carcinoma (ESCC) that included analysis germ line samples from 50 ESCC patients and matched controls. The average genotyping call rate for 100 analyzed was 96%. Using generalized...
Esophageal cancer is one of the most common fatal cancers worldwide. Deletions genomic regions are thought to be important in esophageal carcinogenesis. We conducted a genomewide scan for allelic loss using microdissected DNA from 11 squamous-cell carcinoma patients with family history upper gastrointestinal tract high-risk region north central China. Allelic patterns 366 fluorescently labeled microsatellite markers distributed at 10-cM intervals over 22 autosomal chromosomes were examined....
Trimethoprim-sulfamethoxazole (TMP-SMZ) is the most effective Pneumocystis carinii pneumonia (PCP) prophylactic agent, but adverse reactions are common among human immunodeficiency virus (HIV)—infected patients and limit its use. This randomized, double-blind controlled trial compared 2 methods of TMP-SMZ reintroduction, 6-day dose escalation direct rechallenge, for PCP prophylaxis in HIV-infected who had experienced previous treatment-limiting reactions. The primary end point was ability to...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression tumorigenesis, but it unclear how affect or survival at the genome-wide level ESCC. Methods performed miRNA mRNA arrays 113 ESCC cases with tumor/normal matched tissues to identify dysregulated miRNAs, correlate expressions, relate changes clinical characteristics. Results Thirty-nine were identified whose tissue ratios showed...