A5100765525- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Aeolian processes and effects
- BRCA gene mutations in cancer
- HIV/AIDS drug development and treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Intramuscular injections and effects
- RNA Research and Splicing
Chongqing Cancer Hospital
2020-2025
Chongqing University
2018-2025
University of Chicago
2024-2025
Northeast Agricultural University
2025
The Sixth People's Hospital of Zhengzhou
2024
Academia Sinica
2024
Zhejiang University of Technology
2024
Inner Mongolia Normal University
2024
Tianjin Medical University Cancer Institute and Hospital
2016-2023
National Clinical Research
2018-2023
Helicobacter pylori (Hp) is the primary cause of gastric cancer but we know little its relative abundance and other microbes in stomach, especially at time diagnosis. Here characterized taxonomic derived functional profiles microbiota two different sets patients, compared them with microbial body sites. Paired nonmalignant tumor tissues were sampled from 160 patients 80 China Mexico. The 16S rRNA gene V3-V4 region was sequenced using MiSeq platform for profiles. PICRUSt used to predict Human...
Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the cardia versus non-cardia.Here we present results a GWAS using 2350 East Asian cases as 1189 and 1027 non-cardia 2708 controls. We also included up to 3042 cases, 4359 7548 controls replication from two Chinese one Korean study. From GWAS, selected 12 top SNPs each subtype, 4 total 1 SNP MUC1...
Abstract Gastric cancer and esophageal are the second sixth leading causes of cancer-related death worldwide. Multiple genomic alterations underlying gastric squamous cell carcinoma (ESCC) have been identified, but full spectrum structural variations mutations yet to be uncovered. Here, we report results whole-genome sequencing 30 samples comprising tumor blood from 15 patients, four whom presented with ESCC, seven cardia adenocarcinoma (GCA), noncardia adenocarcinoma. Analyses revealed that...
Affordable early screening in subjects with high risk of lung cancer has great potential to improve survival from this deadly disease. We measured gene expression tissue and peripheral whole blood (PWB) adenocarcinoma cases controls identify dysregulated genes that could be tested identification at-risk patients the future. Genome-wide mRNA analysis was conducted 153 (73 cases, 80 controls) Environment And Genetics Lung Etiology study using PWB paired snap-frozen tumor noninvolved samples....
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression tumorigenesis, but it unclear how affect or survival at the genome-wide level ESCC. Methods performed miRNA mRNA arrays 113 ESCC cases with tumor/normal matched tissues to identify dysregulated miRNAs, correlate expressions, relate changes clinical characteristics. Results Thirty-nine were identified whose tissue ratios showed...
CD19 chimeric antigen receptor T-cell therapy (CD19-CAR) has changed the treatment landscape and outcomes for patients with pre-B-cell acute lymphoblastic leukemia (B-ALL). Unfortunately, primary nonresponse (PNR), sustained CD19+ disease, concurrent expansion of CD19-CAR occur in 20% is associated adverse outcomes. Although some failures may be attributable to loss, mechanisms CD19-independent, leukemia-intrinsic resistance remain poorly understood. We hypothesize that PNR leukemias are...
The 25th International AIDS Conference (AIDS 2024) was held from July 22nd to 26th, 2024, in Munich, Germany, attracting over 15 000 scientists more than 175 countries and regions worldwide discuss the latest advancements future challenges HIV research. We had been eagerly anticipating results presented at conference, hoping see global data on HIV-related cancers, particularly HIV-associated lymphomas (HALs). However, with great disappointment, no reports HALs were available. overall focus...
<title>Abstract</title> <bold>Objective</bold> To explore the clinical characteristics, treatment, and prognosis of patients with newly diagnosed plasmablastic lymphoma (PBL). <bold>Methods</bold> The data 13 PBL admitted to Chongqing University Cancer Hospital from January 2013 June 2024 were retrospectively analyzed. Survival analysis was performed using Kaplan-Meier survival curve Log-rank test. Univariate multivariate Cox regression model analyses used for analyzing prognostic factors....
Abnormal cancer metabolism causes hypoxia and immunosuppression, limiting the anti-tumor efficacy of radiotherapy. Herein, we report a positively charged, mitochondria-targeted nanoscale metal-organic layer conjugated with 3-bromopyruvate (BP), BP/Hf12-Ir, for metabolic reprogramming radiosensitization. BP/Hf12-Ir disrupts oxidative phosphorylation glycolysis, reducing energy production alleviating to enhance radiotherapy immunity. in combination X-ray irradiation inhibits tumor growth by...
Estimations of blood flow shear stress and its distribution have great importance for preventing carotid artery stenosis predicting plaque stability. Physics-informed neural network (PINN) can utilize less data points with unknown boundary conditions obtain high-resolution accurate solutions under the constraints physical equations. This makes PINN well-suited to address clinical hemodynamic modeling problems. However, basic structure might cause an imbalance among loss function terms is...
The delayed decomposition of rice straw in Northeast China’s cold regions (winter temperatures < −20 °C) due to insufficient accumulated temperature requires innovative solutions. This study developed a synergistic approach combining microbial with mechanical burial. Pre-experiments identified optimal parameters for the liquid decomposing agent (100 mg/mL concentration, 6 g/m application rate). A novel combined machine was engineered adjustable parameters: knife roller speed (200–300...
ABSTRACT Estimating the prognosis of people with newly diagnosed AIDS‐related diffuse large B‐cell lymphoma (AR‐DLBCL) is challenging. We did a prospective, multicenter cohort study using data from 306 consecutive subjects, including training ( N = 215) and external validation cohorts 91), to develop validate visual nomogram, termed ARDPI model. Seven co‐variates were independently correlated survival, age, LMR, CD5, blood EBV‐DNA copy number, CD4/CD8, CNS involvement, anti‐HIV therapy...
In China, esophageal cancer is the fourth leading cause of death where essentially all cases are histologically squamous cell carcinoma (ESCC), in contrast to adenocarcinoma West.Globally, ESCC 2.4 times more common among men than women and recently it has been suggested that sex hormones may be associated with risk ESCC.We examined association between genetic variants hormone metabolic genes a population from north central China high-incidence rates.A total 1026 1452 controls were genotyped...
Little is known about the link between gastric microbiota and epidemiology of cancer. In order to determine epidemiologic clinical relevance microbiota, we used 16 S ribosomal RNA gene sequencing analysis characterize composition structure microbial community 80 paired samples (non‐malignant matched tumor tissues) from cardia adenocarcinoma (GCA) patients in Shanxi, China. We also PICRUSt predict functional profiles. Compared without family history upper gastrointestinal (UGI) cancer...
Ischemic stroke (IS) induces neurological damage due to cerebrovascular occlusion. Restoring blood perfusion the ischemic brain area in a timely fashion is most effective treatment strategy. Hypoxia an way of restoring by improving microcirculation, while effect varies greatly depending on hypoxic mode. This study aimed screen for optimal mode improve microcirculation and prevent IS. Here, we found that compared with continuous hypoxia (CH), intermittent (IH) significantly improved cerebral...
Introduction Little is known about the first line induction chemotherapy cycles for HIV-associated diffuse large B-cell lymphoma (DLBCL) as these are less common than HIV-negative lymphoma. Currently, optimal treatment option remains undefined. Therefore, we performed a multi-center study to analyze clinical characteristics and outcomes of DLBCL patients in different modes China. Methods Totally 273 newly diagnosed at eleven academic centers from October 2008 2021, were analyzed. Results In...