A5115592138- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Dermatology and Skin Diseases
- Bioactive Natural Diterpenoids Research
- Appendicitis Diagnosis and Management
- Effects of Radiation Exposure
- Blood groups and transfusion
- Blood properties and coagulation
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Management of metastatic bone disease
- Health, psychology, and well-being
- Viral-associated cancers and disorders
- Multiple and Secondary Primary Cancers
- Sleep and related disorders
- Retinal Diseases and Treatments
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Acute Ischemic Stroke Management
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
Chongqing Cancer Hospital
2024-2025
Chongqing University
2024-2025
Chongqing Academy of Chinese Materia Medica
2018-2024
Changchun University of Chinese Medicine
2024
Beijing University of Chinese Medicine
2024
Beijing Proteome Research Center
2022-2023
China Medical University
2015-2022
Chongqing Medical University
2020-2022
Sheng Jing Hospital
2022
Shanghai Children's Medical Center
2022
The 25th International AIDS Conference (AIDS 2024) was held from July 22nd to 26th, 2024, in Munich, Germany, attracting over 15 000 scientists more than 175 countries and regions worldwide discuss the latest advancements future challenges HIV research. We had been eagerly anticipating results presented at conference, hoping see global data on HIV-related cancers, particularly HIV-associated lymphomas (HALs). However, with great disappointment, no reports HALs were available. overall focus...
Systemic lupus erythematosus (SLE) is a heterogeneous chronic inflammatory autoimmune disorder, in the pathogenesis of which miRNAs play versatile function. The purpose this study was to investigate effect miRNA-410 on SLE T cells patients.Real-time PCR used test mRNA levels patients and healthy controls. ELISA analysis performed examine production IL-10. Luciferase Assay confirm targeting 3'UTR STAT3 mRNA.We found that expression level miR-410 decreased comparing controls, whereas...
Radiation-induced lung injury (RILI) is a major clinical complication for radiotherapy in thoracic tumors. An immediate effect of irradiation the generation reactive oxygen that can produce oxidative damage to DNA, lipids, and proteins resulting cell or death. Currently, medical management RILI remains supportive. Therefore, there an urgent need development countermeasures. The present study aimed evaluate protective manganese superoxide dismutase (MnSOD) gene-modified mesenchymal stem cells...
Although the role of regulatory B cells (Bregs) in rheumatic disease has gained increasing attention, two lesser-known Breg subsets that express either Foxp3 or transforming growth factor beta (TGFβ) are rarely examined studies disease. This study investigates association between relative proportions CD19(+)Foxp3(+) and CD19(+)TGFβ(+) Bregs, clinical indicators severity rheumatoid arthritis (RA) patients with without interstitial lung (ILD).A total 31 RA (14 17 ILD) 26 healthy control...
Psoriasis is a chronic skin disease, and topical sequential therapy with combination of calcipotriol betamethasone currently approved treatment. However, the exact mechanism by which this treatment regimen relieves psoriasis unknown.We assembled cohort 65 patients divided post-treatment into responder group non-responder according to Area Severity Index (PASI) score after 12-week We measured expression levels proteins in collected 130 serum samples using our in-depth proteomics platform...
This study was undertaken to elucidate the pathogenesis and heterogeneity of Behçet's disease (BD) involving different organs using in-depth proteomics identify biomarkers for clinical assessment treatment patients with BD.We measured expression levels proteins in plasma samples from 98 BD 31 healthy controls our platform a data-independent acquisition mass spectrometer antibody microarray. We performed bioinformatics analyses biologic processes signaling pathways that were changed group...
Background: Glioblastoma multiforme (GBM) is the most common malignant tumor in central nervous system with poor prognosis and unsatisfactory therapeutic efficacy. Considering high correlation between tumors angiogenesis, we attempted to construct a more effective model angiogenesis-related genes (ARGs) better predict response prognosis. Methods: The ARG datasets were downloaded from NCBI-Gene Molecular Signatures Database. gene expression data clinical information obtained TCGA CGGA...
Thrombocytopenia 2 (THC2) is one of the most prevalent forms inherited thrombocytopenia. It caused by a heterogeneous group ANKRD26 gene mutation and shows clinical laboratory characteristics. We present big Chinese family with 10 THC2 patients carrying c.-128G>T heterozygous substitution in 5-untranslated region gene. Although platelets are fewer than 50 × 109/L 8 members, only proband her son show higher WHO bleeding score. The also beta-thalassemia carriers c.52A>T HBB, which might not be...
White matter injury (WMI) is the most common brain in preterm infants and can result life-long neurological deficits. The main cause of WMI damage to oligodendrocyte precursor cells (OPC) that results delayed myelin sheath formation, or destruction existing sheaths. OPC undergo highly regulated strictly timed developmental changes their transformation mature oligodendrocytes capable production.Studies have shown clobetasol strongly promotes differentiation into Therefore, we hypothesized may...
Background Asthma, depression, and sleep problems are three significant public health issues that closely interrelated. This study aims to explore the relationship between status asthma, as well potential interaction among these conditions their effects on asthma. Method cross-sectional utilized data from 2005-2008 National Health Nutritional Examination Survey, including information confounding factors. Multivariate logistic regression analyses were conducted investigate status, Subgroup...
Objective Previous studies have demonstrated that grip strength is associated with various health outcomes, including osteoporosis. However, the impact of on long-term mortality risk among individuals low bone mass remains unclear. This study aims to investigate association between and all-cause in population mass. Methods We included 1,343 cases decreased from NHANES database spanning 2013 2014. All-cause data were ascertained through linkage national death index records up December 31,...
<title>Abstract</title> As a source of Tibetan medicine “Dali”, Rhododendron anthopogonoides Maxim (RAM) has good medically helpful effect on respiratory diseases. However, the pharmacological and pharmacodynamic research its active components is still scarce. In order to solve this problem, method network pharmacology used. The RAM were obtained by searching relevant literatures, protein targets screened Traditional Chinese Medicine Database Analysis Platform (TCMSP) with normalizing gene...
: An increased T-helper cell (Th) 1/Th2 ratio in the peripheral blood has been proposed to correlate with disease activity of immune thrombocytopenia (ITP). T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is a Th1-associated surface that regulates Th1 responses promotes tolerance. Consequently, we aimed determine whether regulation TIM-3 expression likely be promising therapeutic approach for ITP. In present study, investigated immunomodulatory activities human...
Lupus podocytopathy is a glomerular lesion in systemic lupus erythematosus (SLE) characterized by diffuse podocyte foot process effacement (FPE) without immune complex (IC) deposition or with only mesangial IC deposition. It rarely seen children SLE. A 13-year-old girl met the 2019 European League Against Rheumatism (EULAR)/ American College of Rheumatology (ACR) Classification Criteria for SLE based on positive ANA; facial rash; thrombocytopenia; proteinuria; and antiphospholipid (aPL)...
Objective: To determine the association of NH2-terminal pro-B-type natriuretic peptide (NT-proBNP) with risk developing type 2 diabetes.Methods: We conducted a prospective analysis impaired glucose regulation participants from Diabetic Identification Center Tianjin Metabolic