A5100380711- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Phytoestrogen effects and research
- Viral-associated cancers and disorders
- Cardiac Ischemia and Reperfusion
- Tea Polyphenols and Effects
- Healthcare and Venom Research
- Cancer Genomics and Diagnostics
- Acupuncture Treatment Research Studies
- Cancer Mechanisms and Therapy
- CNS Lymphoma Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Gastrointestinal disorders and treatments
- Food Quality and Safety Studies
- Neurological Disease Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
Kaiser Permanente
2014-2025
Kaiser Permanente Santa Clara Medical Center
2012-2025
Chengdu Fifth People's Hospital
2025
Hebei Medical University
2014-2024
Fourth Hospital of Hebei Medical University
2023-2024
University of California, Los Angeles
2024
China West Normal University
2024
Nanfang Hospital
2024
Jinan University
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2023
Serrated polyps of the colorectum are a histologically and genetically heterogeneous group lesions, which include classic hyperplasic polyps, sessile serrated adenomas (SSAs), traditional adenomas. Accumulating evidence suggests that they may have different malignancy potentials. This study sought to determine association between presence large colorectal synchronous advanced neoplasia.Among 4,714 asymptomatic subjects who underwent screening colonoscopy, cases neoplasia (tubular adenoma >...
Gastric premalignant conditions (GPMC) are common and include atrophic gastritis, gastric intestinal metaplasia, dysplasia, certain epithelial polyps. GPMC have an increased risk of progression to adenocarcinoma. cancer (GC) in the United States represents important disparity because incidence rates 2- 13-fold greater non-White individuals, particularly early-generation immigrants from regions high GC incidence. The US 5-year survival rate for is 36%, which falls short global standards...
The photoluminescent properties of [Au2(µ-dppm)2]2+[dppm = bis(diphenylphosphino)methane], [Au2(µ-dmpm)3]2+[dmpm bis(dimethylphosphino)methane] and [Cu2(µ-dppm)2(MeCN)4]2+ have been investigated. Irradiation a degassed acetonitrile solution benzyl chloride or 1-bromopentane in the presence sacrificial electron donor such as triethylamine catalytic amount [Au2(µ-dppm)2]2+ led to formation bibenzyl n-decane. Similar photoreactions with much lower yields C–C bond coupling products also observed...
It has been suggested that colorectal cancer be regarded as several subgroups defined according to tumor location rather than a single entity. The current study aimed identify the most useful method for grouping by both baseline and survival characteristics.Cases of pathologically confirmed adenocarcinoma diagnosed from 2000 2012 were identified Surveillance, Epidemiology, End Results database categorized into three groups: right colon (RCC), left (LCC), rectal (ReC). Adjusted hazard ratios...
Background . Pathogenic infection in broilers has become an important issue the development of poultry industry. Xylooligosaccharides released from xylan via xylanase and fermented polysaccharide Hericium caputmedusae (FPHC) have antimicrobial potential against many pathogens. Objective We aimed to explore effects FPHC on pathogenic ( Gallus gallus domesticus ). Methods Three hundred thirty 21‐day male were assigned into four groups: control group (CG, basic diet), (XG, diet + xylanase),...
Microbes are critical for the flavor development of Sichuan South-road Dark Tea (SSDT) during pile-fermentation. However, their mechanism action has not been fully elucidated yet. In this study, SSDT microbial metagenome obtained from different locations piled tea center pile-fermentation metaphase were functionally annotated, and glycoside hydrolase (GH) genes core functional strain comprehensively analyzed. The results revealed that carbohydrate metabolism (8.2%) predominant in total...
To investigate the etiology, clinical manifestations, treatment methods, and prognosis of urethral diverticulum cancer to enhance understanding this disease. This paper reports a case with "hematuria dysuria" as main manifestations. The is discussed in conjunction relevant literature. patient initially presented gynecology department due postmenopausal bleeding but was not diagnosed Subsequently, developed hematuria dysuria referred urology department. MRI indicated diverticulum-like changes...
Most of colorectal adenocarcinomas are believed to arise from adenomas, which premalignant lesions. Sequencing the whole exome adenoma will help identifying molecular biomarkers that can predict occurrence adenocarcinoma more precisely and understanding pathways underlying initial stage tumorigenesis. We performed capture sequencing normal mucosa, tissues same patient sequenced identified mutations in additional 73 adenomas 288 adenocarcinomas. Somatic single nucleotide variations (SNVs)...
Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy Fen Wang,1,* Jia-Dong Pang,2,* Lei-lei Huang,1 Ran Wang,1 Dan Li,3 Kang Sun,4 Lian-tang Li-Ming Zhang2,* 1Department of Pathology, The First Affiliated Hospital Sun Yat-sen University, 2PCFM Lab and GDHPPC Lab, School Materials Science Engineering, Guangzhou, 3Guangdong Provincial Engineering Research Center Molecular Imaging, Fifth Zhuhai, 4School China *These authors contributed equally to this...
The features related to the prognosis of patients with mucinous breast cancer (MBC) remain controversial. We aimed explore prognostic factors MBC and develop a nomogram for predicting survival outcomes.The Surveillance, Epidemiology, End Results (SEER) database was searched identify 139611 women resectable from 1990 2007. Survival curves were generated using Kaplan-Meier methods. 5-year 10-year cancer-specific (CSS) rates calculated Life-Table method. Based on Cox models, constructed predict...
Our preclinical data showed that the leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and B4 receptor type 1 (BLT1) were also associated with CRC survival probability. Clinical samples evaluated to determine whether could serve as therapeutic target (LTB4) be used biomarker for evaluating efficacy bestatin CRC.Patients Stage I-III did or not receive prior surgery. Evaluable pairwise patient blood collected evaluate LTB4 concentration....
Using agro-residues in bioreactors to produce mushrooms is an important component of eco-agriculture. Here, we tested the cultivation Lentinula edodes with corn cob (CC) and straw (CS), then evaluated resulting enzyme activities, agronomic traits, textures nutrient compositions mushrooms. Laccase (T1 formula, 3.26 g U-1) carboxymethyl cellulase (T3 1.01 activities were highest at time for a complete substrate colonization stage (TCSC), while acidic xylanase activity was (CK 4.05 mushroom...
Objective The longitudinal risk of colorectal cancer (CRC) associated with subtypes serrated polyps (SPs) remains incompletely understood. Design This community-based, case–control study included 317 178 Kaiser Permanente Northern California members who underwent their first colonoscopy during 2006–2016. Nested within this population, we identified 695 cases CRC and 3475 CRC-free controls (matched 5:1 to for age, sex year colonoscopy). Two expert pathologists reviewed the tissue slides all...
How altered metabolism contributes to chemotherapy resistance in cancer cells remains unclear. Through a metabolism-related kinome RNAi screen, we identified inositol-trisphosphate 3-kinase B (ITPKB) as critical enzyme that cisplatin-resistant tumor growth. We demonstrated inositol 1,3,4,5-tetrakisphosphate (IP4), the product of ITPKB, plays role redox homeostasis upon cisplatin exposure by reducing cisplatin-induced ROS through inhibition ROS-generating enzyme, NADPH oxidase 4 (NOX4), which...
ABSTRACT Background: Patients with the postural instability and gait difficulty (PIGD) subtype of Parkinson disease (PD) are at a higher risk dysfunction less responsive to dopamine replacement therapy. The PIGD was found largely associate white matter lesions, but details diffusion changes within these lesions have not been fully investigated. Voxel-based analysis for tensor imaging data is one preferred measures compare in each voxel any part brain. Methods: PD patients (n=12) non-PIGD...