A5103932770- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Diabetes and associated disorders
- Cerebrospinal fluid and hydrocephalus
- Biomarkers in Disease Mechanisms
- Connective tissue disorders research
- Protein Kinase Regulation and GTPase Signaling
- Plant Gene Expression Analysis
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Aortic Disease and Treatment Approaches
- Plant Reproductive Biology
- Ion Channels and Receptors
- Aortic aneurysm repair treatments
- Dermatological and Skeletal Disorders
- Phytochemicals and Antioxidant Activities
- Protein Tyrosine Phosphatases
- Plant Molecular Biology Research
- Evolutionary Algorithms and Applications
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Telomeres, Telomerase, and Senescence
- Bone health and osteoporosis research
- RNA Research and Splicing
Peking University
2017-2024
Peking University Third Hospital
2024
Jiangnan University
2024
Tianjin University of Traditional Chinese Medicine
2024
Beihua University
2024
Heilongjiang University of Chinese Medicine
2022
Henan Agricultural University
2021
Ministry of Education of the People's Republic of China
2021
Center for Life Sciences
2017-2020
Tsinghua University
2020
Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity mortality. XBP1 (X-box binding protein 1), existing as the XBP1u (unspliced XBP1) XBP1s (spliced forms, key component of endoplasmic reticulum stress involved vascular diseases. However, whether participates development remains unclear.We aim investigate role calcification. levels were reduced high phosphate-induced calcified smooth muscle cells, aortas from mice...
Most of colorectal adenocarcinomas are believed to arise from adenomas, which premalignant lesions. Sequencing the whole exome adenoma will help identifying molecular biomarkers that can predict occurrence adenocarcinoma more precisely and understanding pathways underlying initial stage tumorigenesis. We performed capture sequencing normal mucosa, tissues same patient sequenced identified mutations in additional 73 adenomas 288 adenocarcinomas. Somatic single nucleotide variations (SNVs)...
ABSTRACT Pancreatic endocrine lineages are derived from pancreatic progenitors that undergo a cell fate transition requiring switch low to high Ngn3 expression. However, the underlying chromatin regulatory mechanisms unclear. Here, we performed epigenomic analysis of gene loci featuring histone marks in cells with or level In combination transcriptomic analysis, discovered Ngn3-high cells, removal H3K27me3 was associated activation key transcription factors and establishment primed active...
The current study aimed to investigate the dynamic changes in brain glymphatic function during chemotherapy breast cancer patients (BCP) and their correlation with cognitive function.
Disturbed metabolism and transport of citrate play significant roles in various pathologies. However, vascular regulation its potential role aortic aneurysm (AA) development remain poorly understood.
Identifying the target proteins of small-molecule drug candidates is important for determining their molecular mechanisms action. Porous membranes derivatized with such small molecules may provide an attractive target-identification platform due to a high protein-capture efficiency during flow through membrane pores. This work employs carbonic anhydrase II (CAII) binding immobilized 4-(2-aminoethyl)benzenesulfonamide (AEBSA) examine and selectivity affinity capture in modified membranes....
Transient receptor potential vanilloid 4 (TRPV4) is a widely expressed cation channel that plays an important role in many physiological and pathological processes. However, most TRPV4 drugs carry risk of side effects. Moreover, existing screening methods are not suitable for the high-throughput (HTS) drugs. In this study, cell model HTS method targeting were established based on calcium-activated chloride protein 1 Anoctamin (ANO1) double mutant (YFP-H148Q/I152L) yellow fluorescent (YFP)....
Apple (Malus × domestica Borkh.) is a perennial woody plant that often suffers from various biological stresses. Many harmful pathogens can infect apple trees and lead to reduced production. We comprehensively identified the WRKY genes in genome analyzed their expression response several stressors, including Alternaria alternata, Pythium ultimum, Botryosphaeria dothidea, Erwinia amylovora, Penicillium expansum, Gymnosporangium yamadae, replant disease. There were 113 MdWRKYs genome....
The purpose of this study was to explore the application status natural products in osteoporosis research and its hotspots future directions by analyzing literature field therapy for from 2000 2021. Publications on were extracted Web Science core collection database. Bibliometrics package R language, VOSviewer CiteSpace software used visualization analysis. From 2021, number articles 1596, total increased rapidly. China driving force field, top-contributing institution Guangzhou University...