A5025651686- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Protein Tyrosine Phosphatases
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Laser-Matter Interactions and Applications
- Solid State Laser Technologies
- Psoriasis: Treatment and Pathogenesis
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Traditional and Medicinal Uses of Annonaceae
- Protein Kinase Regulation and GTPase Signaling
- Fungal Biology and Applications
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
Tsinghua University
2015-2025
State Key Laboratory of Membrane Biology
2018-2024
Hunan First Normal University
2024
Shanxi Medical University
2024
Jiaxing University
2024
Guizhou Center for Disease Control and Prevention
2024
Central China Normal University
2024
University of Jinan
2018-2024
China Pharmaceutical University
2022-2024
Zhejiang Normal University
2023
Abstract Drug combination therapy has the potential to enhance efficacy, reduce dose-dependent toxicity and prevent emergence of drug resistance. However, discovery synergistic effective combinations been a laborious often serendipitous process. In recent years, identification therapies accelerated due advances in high-throughput screening, but informatics approaches for systems-level data management analysis are needed. To contribute toward this goal, we created an open-access portal called...
Traditional Chinese medicine (TCM) has been practiced for thousands of years treating human diseases. In comparison to modern medicine, one the advantages TCM is principle herb compatibility, known as formulae. A formula usually consists multiple herbs achieve maximum treatment effects, where their interactions are believed elicit therapeutic effects. Despite being a fundamental component TCM, rationale combining specific combinations remains unclear. this study, we proposed network-based...
A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, inherent biotoxicity Flu also alleviated.
Combinatorial therapies that target multiple pathways have shown great promises for treating complex diseases. DrugComb (https://drugcomb.org/) is a web-based portal the deposition and analysis of drug combination screening datasets. Since its first release, has received continuous updates on coverage data resources, as well functionality web server to improve analysis, visualization interpretation screens. Here, we report significant DrugComb, including: (i) manual curation harmonization...
The severe acute respiratory syndrome (SARS) has been one of the most epidemic diseases threatening human health all over world. Based on clinical studies, SARS-CoV (the SARS-associated coronavirus), a novel coronavirus, is reported as pathogen responsible for disease. To date, no effective and specific therapeutic method can be used to treat patients suffering from infection. RNA interference (RNAi) process by which introduced small interfering (siRNA) could cause degradation mRNA with...
Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mechanism. interacts with in vitro vivo. presence increased levels, expression decreases, whereas other E3 ligases involved degradation, such as Smurf1 or WWP1, remains constant increases during...
Abstract Since the 2019 novel coronavirus disease (COVID-19) outbreak in and pandemic continues for more than one year, a vast amount of drug research has been conducted few them got FDA approval. Our objective is to prioritize repurposable drugs using pipeline that systematically integrates interaction between COVID-19 drugs, deep graph neural networks, vitro/population-based validations. We first collected all available (n = 3635) related patient treatment through CTDbase. built knowledge...
Seven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated leaves Vaccinium bracteatum. The structures these fungal metabolites have been elucidated by spectroscopic means MS, NMR electronic circular dichroism. A preliminary anti-inflammatory screening lipopolysaccharide (LPS) induced RAW264.7...
Unlike the conventional mode-locked laser where cooling system is normally used for gain medium, here, we propose a new strategy to originally extend modelocked bandwidth through increasing crystal temperature. Mode-locking of thulium-laser with superbroadband (> 600 nm) centered at 2.05-μm has been realized, corresponding pulse duration 26 fs (3.5 optical cycles), which represents shortest pulses ever achieved from Tm/Ho-lasers in 2-μm spectral range and fewest cycles all present-day...
Transforming growth factor-β (TGF-β) signaling is critical in a variety of biological processes such as cell proliferation, differentiation, and apoptosis. TGF-β mediated by group proteins including receptors Smads. It known that different cells can exhibit sensitivities to TGF-β. Several molecular mechanisms, the differential expression receptor levels, have been suggested contributing these differences. Here, we report evidence for novel mechanism regulating sensitivity depends on role...
Signal transducer and activator of transcription 3 (STAT3) is over-activated or phosphorylated in breast cancers. The hyper-phosphorylation STAT3 was attributed to either up-regulated phosphorylation by several tyrosine-kinases down-regulated activity phosphatases. Although factors have been identified phosphorylate STAT3, it remains unclear how dephosphorylated PTPMeg2. aim this study determine the role PTPMeg2 as a phosphatase regulation Immunoprecipitation assays were used interaction...
Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D⁻K (1⁻8), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the compounds elucidated on basis spectroscopic methods that 1 being established by chemical transformation X-ray diffraction analysis. Compounds 2 bore an ester functionality linking pyridone decalin moieties first reported in this class metabolites, while 3 4...
Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, aim to clarify its clinical significance, biological effects, and mechanism CRC. was upregulated CRC cell lines 47.37% (72/152) primary tumors. Amplification detected 48.28% (56/116) tumors, which positively correlated with overexpression (P < 0.001). Multivariate analysis showed that patients protein were significantly associated poor disease-free survival 0.05). accelerated...
Plant-derived nature products, known as herb formulas, have been commonly used in Traditional Chinese Medicine (TCM) for disease prevention and treatment. The herbs traditionally classified into different categories according to the TCM Organ systems Meridians. Despite increasing knowledge on active components of herbs, rationale Meridian classification remains poorly understood. In this study, we took a machine learning approach explore Meridian. We determined molecule features 646 their...
Unlike the conventional mode-locked laser where cooling system is normally used for gain medium, here, we propose a new strategy to originally extend modelocked bandwidth through increasing crystal temperature. Mode-locking of thulium-laser with superbroadband (> 600 nm) centered at 2.05-μm has been realized, corresponding pulse duration 26 fs (3.5 optical cycles), which represents shortest pulses ever achieved from Tm/Ho-lasers in 2-μm spectral range and fewest cycles all present-day...
Unlike the conventional mode-locked laser where cooling system is normally used for gain medium, here, we propose a new strategy to originally extend modelocked bandwidth through increasing crystal temperature. Mode-locking of thulium-laser with superbroadband (> 600 nm) centered at 2.05-μm has been realized, corresponding pulse duration 26 fs (3.5 optical cycles), which represents shortest pulses ever achieved from Tm/Ho-lasers in 2-μm spectral range and fewest cycles all present-day...