A5100329750- Immune Cell Function and Interaction
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Cervical Cancer and HPV Research
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Neurobiology and Insect Physiology Research
- Circular RNAs in diseases
- Psoriasis: Treatment and Pathogenesis
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
University of Manitoba
2015-2024
Jishou University
2019-2024
Affiliated Hospital of Southwest Medical University
2017-2024
Brookhaven National Laboratory
2024
Shanghai Clinical Research Center
2023-2024
Argonne National Laboratory
2024
Nantong University
2013-2023
Dana-Farber Brigham Cancer Center
2022-2023
Cytokine patterns elicited by infection are critical in the regulation of adaptive immune response and resolution infection. Using a murine model pneumonia induced intranasal inoculation with Chlamydia trachomatis mouse pneumonitis (MoPn) biovar, we found that responses cytokine production spleen cells were correlated quantitative growth MoPn lungs C57BL/6 BALB/c mice. Specifically, (H-2d) mice had significantly higher mortality rate slower clearance organism from than did (H-2b). exhibited...
Abstract Although their contribution to host defense against extracellular infections has been well defined, IL-17 and Th17 are generally thought have limited impact on intracellular infections. In this study, we investigated the role mechanisms of IL-17/Th17 in Chlamydia muridarum, an obligate bacterium, lung infection. Our data showed rapid increase production expansion cells following C. muridarum infection significant detrimental vivo neutralization by anti-IL-17 mAb disease course,...
T cells are strongly regulated by oxidizing environments and amino acid restriction. How reprogram metabolism to adapt these extracellular stress situations is not well understood. Here, we show that starvation induce ATF4 in CD4
We previously reported that higher IL-10 production is correlated with lower IFN-gamma production, weaker delayed hypersensitivity (DTH), and slower organism clearance following chlamydial infection in mice. To assess more directly the role of IL-10, we examined protective immunity pathological reaction C57BL/6 gene knockout (KO) wild-type The results showed absence endogenous mice had significantly accelerated developed stronger DTH responses, which could be inhibited by local delivery...
Abstract T cell-mediated immunity as measured by delayed-type hypersensitivity, and IFN-γ production has been shown to be critical for host defense against Chlamydia trachomatis infection in both human animal studies. Using gene-targeted B cell-deficient mice, we examined the role of cells protective C. (mouse pneumonitis) (MoPn) lung infection. mice were observed have a significantly higher mortality rate vivo chlamydial growth than did wild-type following MoPn Interestingly, not only...
The hyaluronan (HA) receptor RHAMM is an important regulator of cell growth. Overexpression transforming and required for H-ras transformation. molecular mechanism underlying growth control by other extracellular matrix receptors remains largely unknown. We report that soluble induces G2/M arrest suppressing the expression Cdc2/Cyclin B1, a protein kinase complex essential mitosis. Down-regulation use dominant negative mutants or antisense mRNA also decreases Cdc2 levels. Suppression occurs...
Abstract Type I IFNs (IFNIs) have pleiotropic functions in regulating host innate and adaptive immune responses to pathogens. To elucidate the role of IFNIs resistance chlamydial infection vivo, we compared IFN-α/β receptor knockout (IFNAR−/−) wild-type control mice susceptibility Chlamydia trachomatis mouse pneumonitis (Chlamydia muridarum) lung infection. We found that IFNAR−/− were significantly more resistant C. muridarum showing less bacterial burden bodyweight loss, milder pathological...
Abstract SND1 is an AEG-1/MTDH/LYRIC-binding protein that upregulated in numerous human cancers, where it has been assigned multiple functional roles. In this study, we report its association with the TGFβ1 signaling pathway, which promotes epithelial–mesenchymal transition (EMT) breast cancer. was cancer tissues, particular primary invasive ductal carcinomas. Transcriptional activation of gene controlled by TGFβ1/Smad specifically Smad2/Smad3 complex. The promoter region contained several...
Tongue diagnosis, as a unique method of traditional Chinese medicine (TCM), was used to discriminate physiological functions and pathological conditions by observing the changes tongue coating. The aims present study were explore potential screening early diagnosis cancer through evaluating differences images coating microbiome on DS01-B diagnostic information acquisition system photograph analyze next-generation sequencing technology determine V2-V4 hypervariable regions 16S rDNA...
Previous studies have demonstrated the significant impact of NK cells on adaptive Immune responses against chlamydial infections through modulating DCs, yet molecular mechanisms remain incompletely understood. Thisstudy investigates role in DCs signaling pathways and recruitment during Chlamydia muridarum infection. Transcriptomic analyses revealed downregulation key genes from NK-depleted mice, involved type I immunity, including IL12rb2, IL-18rap, chemokine components such as Ccl3, Ccl5,...
Delayed-type hypersensitivity (DTH) has been demonstrated to be a Th1 type immune response which is important in the host defense against infection with intracellular bacteria, including Chlamydia. In present study, we surprisingly observed that C. trachomatis mouse pneumonitis MoPn-infected IFN-γ gene knockout (KO) mice mounted strong DTH responses following foopad challenge inactivated organisms. The KO were associated Th2 cytokine production and partially blocked by anti-IL-4 monoclonal...
The efficacy of DNA vaccination for prevention Chlamydia trachomatis infection was studied using the murine model pneumonia induced by mouse pneumonitis (MoPn) isolate C. trachomatis. Intramuscular immunization with two chlamydial genes, one that encodes major outer-membrane protein (MOMP) and a cytoplasmic enzyme (cytosine triphosphate [CTP] synthetase) were tested. MOMP vaccine but not CTP synthetase generated significant delayed-type hypersensitivity serum antibodies to MoPn elementary...
Differential activation of CD4+ T cell subsets in vivo leads to the development qualitatively different effector responses. We identify an approach that allows selective strongly Th1-dominated immune responses protein antigens. Whereas administration ovalbumin (OVA) induces cytokine synthesis is neither Th1 nor Th2 dominated, glutaraldehyde polymerized, high relative molecular weight OVA (OA-POL) 20-fold increase ratio interferon gamma (IFN-gamma)/IL-4 and IFN-gamma/IL-10 observed after...
IFN-γ-mediated inducible nitric oxide synthase (iNOS) expression is critical for controlling chlamydial infection through microbicidal (NO) production. Interleukin-17A (IL-17A), as a new proinflammatory cytokine, has been shown to play protective role in host defense against Chlamydia muridarum (Cm) infection. To define the related mechanism, we investigated, present study, effect of IL-17A on IFN-γ induced iNOS and NO production during Cm vitro vivo. Our data showed that significantly...
Tudor staphylococcal nuclease (Tudor-SN) is a multifunctional protein implicated in variety of cellular processes. In the present study, we identified Tudor-SN as novel regulator cell cycle. was abundant proliferating cells whereas barely expressed terminally differentiated cells. Functional analysis indicated that ectopic overexpression promoted G1/S transition, knockdown caused G1 arrest. Moreover, live-cell time-lapse experiment demonstrated cycle MEF(-/-) (knock-out mouse embryonic...
Dental pulp stem cells (DPSCs) and from human exfoliated deciduous teeth (SHED) are types of dental tissue‑derived mesenchymal (MSCs). These possess a capacity for self‑renewal, multilineage differentiation potential immunomodulatory functions. Previous studies have reported that DPSCs SHED may be beneficial in regenerative treatments immunotherapy. The substantial expansion vitro is prerequisite to obtaining adequate cell numbers required cell‑based therapy. However, the regeneration...
Abstract Strategies for eradicating cancer stem cells (CSCs) are urgently required because CSCs resistant to anticancer drugs and cause treatment failure, relapse metastasis. Here, we show that photoactive functional nanocarbon complexes exhibit unique characteristics, such as homogeneous particle morphology, high water dispersibility, powerful photothermal conversion, rapid photoresponsivity excellent stability. In addition, the present biologically permeable second near-infrared (NIR-II)...
Staphylococcus aureus (S. aureus) is a leading cause of both healthcare-and community-associated infections globally, which result in severe disease and readily developing antibiotic resistance. Developing an efficacious vaccine against S. urgently required. In the present study, we selected five conserved antigens, including secreted factors α-hemolysin (Hla), staphylococcal enterotoxin B (SEB) three surface proteins protein A (SpA), iron determinant N2 domain (IsdB-N2) manganese transport...
Objective With the evolving spectrum of diseases, psychological conditions such as anxiety and depression have emerged significant global public health concerns. Notably, these disorders are prevalent among patients suffering from knee osteoarthritis (KOA). Consequently, this study included 360 hospitalized diagnosed with KOA to examine their levels analyze factors influencing states. Methods A cohort Second Hospital Shanxi Medical University was assessed using a general condition...