A5049225588- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Bacterial biofilms and quorum sensing
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Antibiotic Resistance in Bacteria
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Clostridium difficile and Clostridium perfringens research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Service-Oriented Architecture and Web Services
- Urologic and reproductive health conditions
- Reproductive tract infections research
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Renal and related cancers
- Epigenetics and DNA Methylation
Army Medical University
2016-2025
Sichuan University
2008-2025
West China Hospital of Sichuan University
2005-2025
Army Medical College
2022-2024
Guangxi University
2022-2024
Xiangnan University
2024
Chinese Academy of Sciences
2023-2024
Institute of Software
2023-2024
Hunan Agricultural University
2024
Inner Mongolia University
2024
Abstract 2019 Novel Coronavirus (2019-nCoV) is a virus identified as the cause of outbreak pneumonia first detected in Wuhan, China. Investigations on transmissibility, severity, and other features associated with this are ongoing. Currently, there no vaccine or therapeutic antibody to prevent infection, more time required develop an effective immune strategy against pathogen. In contrast, specific inhibitors targeting key protease involved replication proliferation most means alleviate...
Gastric cancer (GC) continues to be the most common gastrointestinal malignancy in China, and tumor metastases are a major reason for poor prognosis. Circular RNAs (circRNAs) an intriguing type of noncoding with important regulatory roles. However, roles circRNAs GC metastasis have not been fully elucidated. Here, we reported that circ-transportin 3 (TNPO3) was significantly downregulated 103 pairs tissues compared matched noncancerous tissues. The level circ-TNPO3 expression correlated...
The stability of protein drugs remains one the key hurdles to their success in market. aim present study was design a novel nanoemulsion drug-delivery system (NEDDS) that would encapsulate standard-model drug--bovine serum albumin (BSA)--to improve drug stability.The BSA NEDDS prepared using phase-inversion method and pseudoternary phase diagrams. following characteristics were studied: morphology, size, zeta potential, loading, encapsulation efficiency. We also investigated NEDDS,...
Plasmid-free Chlamydia trachomatis and muridarum fail to induce severe pathology. To evaluate whether the attenuated pathogenicity is due insufficient infection or inability of plasmidless chlamydial organisms trigger pathological responses, we compared plasmid-competent plasmid-free C. infections in 5 different strains mice. All developed hydrosalpinx following intravaginal inoculation with plasmid-competent, but not plasmid-free, muridarum. The lack induction by correlated significantly...
Abstract Pseudomonas aeruginosa is a formidable pathogen that responsible for diverse spectrum of human infectious diseases, resulting in considerable annual mortality rates. Because biofilm formation and its ability rapidly acquires resistance to many antibiotics, P . related infections are difficult treat, therefore, developing an effective vaccine the most promising method combating infection. In present study, we designed novel trivalent vaccine, PcrV 28-294 -OprI 25-83 -Hcp1 1-162...
Chronic stress could induce cancer metastasis by constant activation of the sympathetic nervous system, while cellular mechanism remains obscure. The aim this research is to explore associated negative effect chronic stress. analysis transcriptome sequencing implied that STAT3 signaling pathway downregulated miR-337-3p might be a potential epithelial mesenchymal transition (EMT) cell and promote under We also verified biological process in further experiments. Downregulation downregulate...
Lung adenocarcinoma (LUAD) is one of the leading fatal malignancy with high morbidity and mortality worldwide. However, due to its complicated mechanism lack effective clinical therapeutics, early diagnosis prognosis are still unsatisfactory. Most previous studies focused on cancer stem cells (CSCs), relationship between stemness (stem-like characteristics) anti-tumor immunity has not been clearly revealed. Therefore, this study aimed comprehensively analyze role tumor microenvironment (TME)...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although dysbiosis and gut microbiota have been associated with NSCLC, their relative contributions are unclear; in addition, roles distant metastasis (DM) still illusive. We recruited total 121 participants, including 87 newly diagnosed treatment-naive NSCLC patients various stages 34 healthy volunteers, surveyed fecal sputum microbiota. compared microbial profiles between groups, identified...
RNA binding proteins (RBPs) play a key role in genome regulation. Here we report the post-transcript regulation of IGF2BP3, which belongs to insulin-like growth factor 2 mRNA protein family. We used iRIP-seq and RNA-seq analyze transcript alternative splicing on IGF2BP3 treated with overexpression cells control. Overexpressed has broadly increased genes expression involved G-protein coupled receptor signaling pathway, positive cell proliferation, signal transduction. regulated multiple...
Staphylococcus aureus (S. aureus) is a leading cause of both healthcare-and community-associated infections globally, which result in severe disease and readily developing antibiotic resistance. Developing an efficacious vaccine against S. urgently required. In the present study, we selected five conserved antigens, including secreted factors α-hemolysin (Hla), staphylococcal enterotoxin B (SEB) three surface proteins protein A (SpA), iron determinant N2 domain (IsdB-N2) manganese transport...
Background: Caffeic Acid Phenethyl Ester (CAPE), an active extract of propolis, has recently been reported to have broad applications in various cancers. However, the effects CAPE on Small Cell Lung Cancer (SCLC) are largely unknown. Therefore, aim this study was determine anti-proliferative effect and explore underlying molecular mechanisms SCLC cells using high-throughput sequencing bioinformatics analysis. Methods: Small-cell lung cancer H446 were treated with CAPE, cell proliferation...
Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, quality control of CP and individual variation patients different studies make it rather difficult to evaluate efficacy risk coronavirus disease 2019 (COVID-19). We aimed explore potential therapy, assess possible factors associated with its efficacy. enrolled eight critical or severe COVID-19 from four centers. Each patient was transfused 200-400 mL...
Vaccination strategies for rapid protection against multidrug-resistant bacterial infection are very important, especially hospitalized patients who have high risk of exposure to these bacteria. However, few such vaccination exist due a shortage knowledge supporting their effect. Here, we demonstrated that single intranasal immunization inactivated whole cell Acinetobacter baumannii elicits broad A. -infected pneumonia via training innate immune response in Rag1 -/- mice....