A5075218726- Birth, Development, and Health
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- EEG and Brain-Computer Interfaces
- Air Quality and Health Impacts
- Cervical Cancer and HPV Research
- Energy and Environment Impacts
- Congenital Heart Disease Studies
- Neuroscience and Neural Engineering
- Monoclonal and Polyclonal Antibodies Research
- Advanced Neural Network Applications
- Single-cell and spatial transcriptomics
- Parvovirus B19 Infection Studies
- Tracheal and airway disorders
- Cardiac Valve Diseases and Treatments
- Hemoglobinopathies and Related Disorders
- Adipose Tissue and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Trace Elements in Health
- Reproductive tract infections research
- Iron Metabolism and Disorders
- Infective Endocarditis Diagnosis and Management
National Health and Family Planning Commission
2024
Peking University
2013-2024
Sir Run Run Shaw Hospital
2019-2024
Zhejiang University
2004-2024
Shenzhen International Travel Health Care Center
2024
Xi’an Jiaotong-Liverpool University
2024
Soochow University
2022-2024
Shanxi Medical University
2023-2024
Peking University Third Hospital
2024
Third Affiliated Hospital of Zhengzhou University
2024
To develop an effective and sustainable cell therapy for sickle disease (SCD), we investigated the feasibility of targeted disruption BCL11A gene, either within exon 2 or at GATAA motif in intronic erythroid-specific enhancer, using zinc finger nucleases human bone marrow (BM) CD34+ hematopoietic stem progenitor cells (HSPCs). Both targeting strategies upregulated fetal globin expression erythroid to levels predicted inhibit hemoglobin S polymerization. However, complete inactivation...
ABP 215 is a biosimilar product to bevacizumab. Bevacizumab acts by binding vascular endothelial growth factor A, inhibiting cell proliferation and new blood vessel formation, thereby leading tumor vasculature normalization. The analytical similarity assessment was designed assess the structural functional of bevacizumab sourced from both United States (US) European Union (EU). Similarity also made between US- EU-sourced two products. physicochemical properties were characterized using...
Recombinant factor VIII Fc fusion protein (rFVIIIFc) is a long-acting coagulation approved for the treatment of hemophilia A. Here, rFVIIIFc manufacturing process and results studies evaluating product quality capacity to remove potential impurities viruses are described. This utilized readily transferable scalable unit operations employed multi-step purification viral clearance processing, including novel affinity chromatography adsorbent 15 nm pore size virus removal nanofilter. A cell...
Background: Breastfeeding could improve a child’s health early on, but its long-term effects on childhood behavioral and emotional development remain inconclusive. We aimed to estimate the associations of feeding practice with development. Methods: In this population-based birth cohort study, data patterns for first 6 mo life, duration breastfeeding, children’s outcomes were prospectively collected from 2489 mother–child dyads. Feeding included exclusive breastfeeding (EBF) non-exclusive...
This paper discusses the application and advantages of machine learning in anomaly detection network security traffic. By summarizing existing methods techniques detection, this focuses on progress clustering, classification, statistics, information theory research. In particular, innovations data preprocessing, feature selection, algorithm design, such as experimental validation based an improved KNN algorithm, demonstrate potential improving accuracy efficiency. future, amount increases...
The appearance quality of fruits affects consumers’ judgment their value, and grading the is an effective means to improve added value. purpose this study transform pear into classification categories under several indexes based on industry standards design distinguishing features for training classifier. transformed shapes, surface colors defects. symmetry feature quasi-rectangle were designed back propagation (BP) neural network was trained distinguish standard shape, apical shape...
Objective This study offers a bibliometric analysis of the current situation, hotspots, and cutting-edge domains genetic factors adolescent idiopathic scoliosis (AIS). Methods All publications related to AIS from January 1, 1992, February 28, 2023, were searched Web Science. CiteSpace software was employed for analysis, collecting information about countries, institutions, authors, journals, keywords each article. Results A cumulative number 308 articles have been ascertained. Since 2006,...
Most studies have focused on overweight/obesity and its secular trend, with insufficient the factors influencing thinness trends recently. To examine of prevalence sociodemographic determinants thinness, overweight, obesity among Chinese children adolescents aged 7 to 18 years from 2010 2018.This study was based cross-sectional data 11,234 Family Panel Studies (CFPS) in 2010, 2014, 2018, including anthropometric characteristics variables. The nutritional status each individual determined...
Abstract Monoclonal antibodies that block the interaction between programmed cell death 1 (PD-1) and its ligand (PD-L1) have revolutionized cancer immunotherapy. However, immunogenic responses to these new therapies—such as development of antidrug (ADAs) neutralizing (NAbs)—may represent a significant challenge both efficacy safety in some patients. Dostarlimab (TSR-042) is an approved, humanized, anti-PD-1 monoclonal antibody has shown multiple solid tumor types. Here, we report results...
Ambient fine particulate matter (PM2.5) is a major environmental health problem worldwide, and recent studies indicate that maternal PM2.5 exposure closely associated with congenital heart diseases (CHDs) in offspring. We previously found supplementation folic acid (FA) or Resveratrol (RSV) could protect against defects zebrafish embryos exposed to extractable organic (EOM) from by targeting aryl hydrocarbon receptor (AHR) signaling reactive oxygen species (ROS) production respectively....
Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity. To thoroughly characterize the temporal nature antitumor immune responses, we developed a 34-parameter spectral flow cytometry panel performed high-throughput analyses critical contexts. We leveraged two distinct preclinical models that recapitulate cancer immunoediting (NPK-C1) checkpoint blockade (ICB) response (MC38), respectively, profiled multiple relevant...
Affinity selection-mass spectrometry (AS-MS) is a sensitive technology for identifying small molecules that bind to target proteins, and assays enabled by AS-MS can be used delineate relative binding affinities of ligands proteins. 'Indirect' employ size-exclusion techniques separate target-ligand complexes from unbound ligands, target-associated are then specifically detected liquid chromatography mass spectrometry. We report how indirect with known reference control compounds were as...
Abstract Massively parallel sequencing (MPS) on DNA nanoarrays provides billions of reads at relatively low cost and enables a multitude genomic applications. Further improvement in read length, sequence quality reduction will enable more affordable accurate comprehensive health monitoring tests. Currently the most efficient MPS uses dye-labeled reversibly terminated nucleotides (RTs) that are expensive to make challenging incorporate. Furthermore, part dye-linker (scar) remains nucleobase...