A5102857876- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Pluripotent Stem Cells Research
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Renal and related cancers
- Carcinogens and Genotoxicity Assessment
- Congenital heart defects research
- CRISPR and Genetic Engineering
- Traditional Chinese Medicine Studies
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- PI3K/AKT/mTOR signaling in cancer
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Gut microbiota and health
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Tissue Engineering and Regenerative Medicine
- Intravenous Infusion Technology and Safety
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Sir Run Run Shaw Hospital
2025
Monash University
2025
Soochow University
2014-2024
Northeast Agricultural University
2024
Dali University
2023
Sichuan Mianyang 404 Hospital
2022
The First People's Hospital of Changzhou
2022
Shenyang First People's Hospital
2022
Early diagnosis of Alzheimer's disease (AD) is an attractive strategy to increase the survival rate patients.
Abstract Hypoplastic left heart syndrome (HLHS) is a serious congenital cardiovascular malformation resulting in hypoplasia or atresia of the ventricle, ascending aorta, and aortic mitral valves. Diminished flow through side clearly key contributor to condition, but any myocardial susceptibility component as yet undefined. Using recent advances field induced pluripotent stem cells (iPSCs), we have been able generate an iPSC model HLHS characterize properties cardiac myocytes (CMs)...
Abstract Embryonic stem cells (ESCs) exhibit unique attributes of boundless self-renewal and pluripotency, making them invaluable for fundamental investigations clinical endeavors. Previous examinations microgravity effects on ESC differentiation have predominantly maintained a descriptive nature, constrained by limited experimental opportunities techniques. In this investigation, we present compelling evidence derived from murine human ESCs, demonstrating that simulated (SMG)-induced stress...
Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes in which NADPH oxidase defective generating reactive oxygen species. In this study, we reprogrammed three normal unrelated patient's fibroblasts (p47(phox) and gp91(phox) ) to pluripotency by lentiviral transduction with defined factors. These induced pluripotent stem cells (iPSC) share the morphological features human embryonic cells, express key factors, possess high telomerase activity. Furthermore, all iPSC lines...
A nontargeted metabolomics approach was developed to examine metabolic differences in serum samples from the mild cognitive impairment and Alzheimer's disease subjects.
Our previous observations indicated that extractable organic matter (EOM) from PM2.5 induced malformations in the heart of zebrafish embryos by activating AhR and inhibiting canonical Wnt/β-catenin signal pathway. As a nutritional factor, folic acid (FA) is reported to prevent cardiac defects during embryo development. Hence, we hypothesize FA may PM2.5-induced interfering with signaling pathways. results showed supplementation alleviated EOM-induced embryos, both inhibitor CH223191 Wnt...
The IMP-4 carbapenemase is an endemic cause of carbapenem resistance in the Asia-Pacific region. Our aim was to determine dissemination mechanism blaIMP-4 gene. Twelve representative Australian clinical isolates from Alfred Hospital, were characterised using antimicrobial susceptibility testing and genome plasmid assemblies analysed. Conjugation efficiencies different plasmids investigated filter mating with four recipient strains across two species. Selected included six species genera...
Differentiated thyroid carcinoma (DTC) is the most frequent endocrine cancer, with a high incidence in young population. Patients postoperative DTC are usually considered increased risk of bone loss, possibly due to stimulating hormone (TSH) suppression therapy. However, it remains unclear whether vitamin D and calcium supplementation beneficial on metabolism patients malnutrition after thyroidectomy DTC. In this one-year prospective study, adult men younger than 50 years or premenopausal...
Lately, an increasing number of studies have investigated the relationship between metformin and gut microbiota, suggesting that exerts part its hypoglycemic effect through microbes. However, underlying mechanism remains largely undetermined. In present study, we effects on microbiota metabolome profiles in serum compared it with insulin treatment rats type 2 diabetes mellitus (T2DM). Diabetic (DM group) were induced by a combination streptozotocin high-fat diet (HFD). After 7 days, DM...
Severe sepsis (SS) remains among the leading causes of death in both developed and developing countries.
Trichloroethylene (TCE), widely used as an organic solvent in the industry, is a common contaminant air, soil, and water. Chronic TCE exposure induced hepatocellular carcinoma mice, occupational humans was suggested to be associated with liver cancer. To understand role of non-genotoxic mechanism(s) for action, we examined gene expression DNA methylation changes B6C3F1 mice orally administered (0, 100, 500 1000 mg/kg b.w. per day) 5 days. After days treatment at dose level b.w., total 431...
Urinary UPLC-MS metabolomics could dissect the underlying mechanisms of HXC protects against SS.
Non-targeted mass spectrometry was used to characterize peripheral biomarkers associated with the urine metabolome in severe sepsis (SS) patients. This is an efficient and convenient tool for diagnosing screening of SS a high-risk population.
Sepsis is a commonly encountered scenario in an intensive care unit (ICU), and the kidney one of organs frequently affected.
Lung adenocarcinoma (LUAD) is the most common types among lung cancers generally arising from terminal airway and understanding of multistep carcinogenesis crucial to develop novel therapeutic strategy for LUAD. Here we used human induced pluripotent stem cells (hiPSCs) establish iHER2-hiPSCs in which doxycycline expression oncoprotein epidermal growth factor receptor 2 (HER2)/ERBB2. progenitors that differentiated iHER2-hiPSCs, expressed NKX2-1/TTF-1 known as a lineage maker, were...
Abstract Background Soybean ( Glycine max ), a vital grain and oilseed crop, serves as primary source of plant protein oil. Soil salinization poses significant threat to soybean planting, highlighting the urgency improve resilience adaptability saline stress. Melatonin, recently identified key growth regulator, plays crucial roles in growth, development, responses environmental However, potential melatonin mitigate alkali stress soybeans underlying mechanisms remain unclear. Results This...