A5100632385- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Cardiac Ischemia and Reperfusion
- Renal and related cancers
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Pneumonia and Respiratory Infections
- Metabolomics and Mass Spectrometry Studies
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
Tianjin Institute of Industrial Biotechnology
2025
Chinese Academy of Sciences
2006-2025
Nanjing Medical University
2016-2025
Jilin University
2023-2025
First Hospital of Jilin University
2024-2025
Ruijin Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Shanghai Institute of Hematology
2024-2025
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Abstract Background The α 2 -adrenoreceptor agonist dexmedetomidine is known to provide renoprotection against ischemia and reperfusion (I/R) injury. However the underlying molecular mechanisms remain unclear. purpose of this study was investigate whether Janus kinase signal transducer activator transcription (JAK/STAT) signaling pathway plays a role in dexmedetomidine’s renoprotection. Methods I/R model induced by bilateral renal pedicle clamping for 45 min followed 48 h male Wistar rat....
Abstract Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be downregulated in epilepsy. However, ferroptosis epilepsy remains unclear. In this study, bioinformatics analysis, analysis patient blood samples and mouse experiments revealed strong associations among epilepsy, ferroptosis, microRNA-211-5p purinergic receptor P2X 7 (P2RX7). P2RX7 nonselective...
Hydroxylation of C25 C–H bonds (referring to sterols) is great importance in vivo for metabolizing sterols and vitamin Ds. The biocatalytic hydroxylation restricted by the selectivity activity enzymes due inertness these bulky compounds. Herein, we employed fungal unspecific peroxygenase from Agrocybe aegerita (AaeUPO) as catalyst develop efficient selective AaeUPO variants through protein engineering. After three rounds evolution using semirational design, 2 variants, G195A/G241V/G318V...
A nontargeted metabolomics approach was developed to examine metabolic differences in serum samples from the mild cognitive impairment and Alzheimer's disease subjects.
Mild cognitive impairment (MCI) confers an increased risk of developing Alzheimer's disease (AD).
The scarcity of donor kidneys greatly impacts the survival patients with end-stage renal failure. Pigs are increasingly becoming potential organ donors but limited by immunological rejection. Based on human kidney organoid already established CHIR99021 and FGF9 induction strategy, we generated porcine organoids from naïve-like ESCs (nESCs). derived had a tubule-like constructure matrix components. expressed markers including AQP1 (proximal tubule), WT1 PODO (podocyte), CD31 (vascular...
Testicular torsion is a common emergency in adolescents, and can lead to severe ischemia reperfusion injury (IRI). LncRNA H19 has been shown increase during ischemia, but its role testicular IRI remains unknown. Focusing on this research gap, we utilized biallelic mutant mice Sertoli cell line (TM4) construct vivo vitro models of ischemia/reperfusion (I/R) oxygen-glucose deprivation/reperfusion (OGD/R). Compared WT I/R mice, H19-/- showed milder tissue disorganization loss, with more intact...
It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of central nervous system, oxidative stress, inflammation, and endocrine immune dysfunction. Increased age, predisposed comorbidity, long surgery time, prolonged stay in intensive care unit have to be risk factors for developing POCD cardiac surgery. In present study, early after colorectal were investigated. Eighty patients, who provided informed consents their participation this...
To explore the therapeutic effects of early enteral nutrition (EEN) on patients with sepsis mechanical ventilation.Patients ventilation in medical intensive care unit (ICU) from January 2013 to March 2016 were treated nutrition. Patients within 48 hours initiation assigned EEN group, and rest delayed (DEN) group. Peripheral blood Th17 cells Treg cells, endotoxin (ET) level, 28-day mortality, duration ventilation, lengths ICU stay hospital stay, incidence ICU-acquired weakness (ICU-AW)...
Abstract Background Enhanced recovery after surgery (ERAS) protocols were rapidly adopted in many surgeries such as fast-track arthroplasty. The study aimed to investigate the impact of ERAS on clinical effect total knee arthroplasty (TKA) via midvastus approach. Methods A 69 patients who underwent primary unilateral TKA approach from October 2018 June 2019 enrolled and randomly divided into two groups: group Control group. for consisted pure juice drinking 2 h before surgery, optimization...
Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether also alleviate senile animals.Senile male C57BL/6 mice (20 months) received (50 μg/kg, i.p.) or vehicle 30 minutes prior to isoflurane exposure (1.3% for 4 h). Cognitive function was assessed 19 days later using a 5-day testing regimen with Morris water maze. Some subjects pretreatment α2 adrenoreceptor antagonist...
The mortality of sepsis is increasing and conventional therapies for it have no better therapeutic effects. We investigated the effects adiponectin (APN) on high mobility group box 1 (HMGB1) in polymicrobial mouse models. Sepsis models were established by cecal ligation puncture (CLP) BALB/c mice. Animals randomly divided into four groups including control (C group), model (CLP early APN treatment (APN + CLP late group). Mice each killed at 6, 12, 24, 48 hr after CLP, respectively, to...
Low L3 skeletal muscle area (SMA), which is assessed on computed tomography (CT) images, has been reported to indicate poor clinical outcomes of patients with acute exacerbation chronic obstructive pulmonary disease (COPD). The dorsal group at the T12 vertebral level (T12DMA) was used as an alternative SMA. This study aimed investigate whether T12DMA could be a predictor in-hospital mortality and long-term survival in elderly COPD admitted intensive care unit (ICU). single-center...
Sepsis is considered to be the most common contributing factor in development of acute kidney injury (AKI). However, mechanisms by which sepsis leads AKI remain unclear. Autophagy important for a number fundamental biological activities and plays key role numerous different diseases. The present study demonstrated that autophagy involved sepsis‑induced upregulates ATG7, LC3 Beclin I. In addition, it was revealed miR‑526b decreased injury, identified as direct regulator ATG7. Furthermore,...
Background and objectives Gap junctions play a pivotal role in contributing to the formation of astroglial networks chronic pain. However, mechanisms underlying dysfunction gap pain have not been fully elucidated. Methods Chronic constriction injury (CCI) sciatic nerve was used establish rat neuropathic model. C6 cells were perform experiments vitro. Von Frey hairs Hargreave’s method determine withdrawal threshold rats. Protein expression detected by immunofluorescence western blotting....
Preoperative evaluation of hepatic functional reserve in patients with hilar cholangiocarcinoma (hCCA) has vital clinical significance for prevention posthepatectomy liver failure (PHLF) and mortality. The aim the present study was to evaluate indocyanine green retention rate at 15 minutes (ICG R15) related factors postoperative outcomes hCCA. 147 who scheduled hCCA resection underwent a preoperative ICG test between May 2015 2020 were prospectively analyzed. Single-factor analysis used risk...