A5100405439- Cervical Cancer and HPV Research
- Genital Health and Disease
- Head and Neck Cancer Studies
- Prenatal Screening and Diagnostics
- Molecular Biology Techniques and Applications
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Fetal and Pediatric Neurological Disorders
- Photodynamic Therapy Research Studies
- Bacterial Infections and Vaccines
- Uterine Myomas and Treatments
- Platelet Disorders and Treatments
- Reproductive tract infections research
- Medical Imaging and Pathology Studies
- Nonmelanoma Skin Cancer Studies
- Urinary and Genital Oncology Studies
- Covalent Organic Framework Applications
- Ultrasound and Hyperthermia Applications
- Advanced Biosensing Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Hormonal and reproductive studies
- Nerve injury and regeneration
- Multiple and Secondary Primary Cancers
- Heparin-Induced Thrombocytopenia and Thrombosis
Bengbu Medical College
2024-2025
Fujian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2023
Peking Union Medical College Hospital
2005-2023
Guangzhou Medical University
2020
Third Affiliated Hospital of Guangzhou Medical University
2020
Yang Hospital
2020
Key Laboratory of Guangdong Province
2020
Guangzhou Institute of Dermatology
2020
Peking University First Hospital
2018
Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China's national cervical cancer screening program.To evaluate hrHPV as a new modality for program.This population-based, multicenter, open-label, randomized clinical trial took place across 20 primary health care centers in urban and rural areas China. At least 3000 women aged 35 to 64 years per site were invited participate, total 60 732 evaluated.At baseline, randomly assigned cytology,...
Importance The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation chronic obstructive pulmonary disease (COPD) is unknown. Objective To determine whether use NPPV vs low-intensity reduces COPD and hypercapnia. Design, Setting, Participants Randomized clinical trial conducted at 30 general respiratory non–intensive care unit wards Chinese hospitals from January 3, 2019, to 31, 2022; last...
Distant metastasis after hepatectomy for hepatocellular carcinoma (HCC) significantly impairs long-term outcome. This study aimed to identify patterns, risk factors, and develop a prediction model distant at first recurrence following HCC resection. multi-center retrospective included patients undergoing curative HCC. Risk factors were identified using Cox regression. A nomogram was constructed validated the concordance index (C-index) calibration curves. Among 2,705 patients, 1,507...
The emergence of drug-resistant Streptococcus pneumoniae poses new clinical challenges and may also reflect a change in the epidemiology S. infections. A variety studies have shown that infections are linked to antimicrobial use. It has been hypothesized persons high socioeconomic status at increased risk for infection because greater access drugs. To assess whether median household income is associated with penicillin-nonsusceptible infections, authors geocoded data from population-based...
The development of highly sensitive HPV-genotyping tests has opened the possibility treating HPV-infected women before high-grade lesions appear. lack efficient intervention for persistent high-risk HPV infection necessitates need novel therapeutic strategy. Here we demonstrate that REBACIN®, a proprietary antiviral biologics, shown potent efficacy in clearance infections. Two independent parallel clinical studies were investigated, which total 199 patients enrolled and randomly divided into...
Abstract Introduction Intravenous leiomyomatosis (IVL) is currently regarded as a special variant of the common uterine leiomyoma (LM). Though IVL shows similar histological morphology to LM, characterized by unique intravenous growth patterns and low‐grade malignant potential, which are quite different from LM. There few studies underlying molecular alterations IVL, though this information important for understanding pathogenesis disease, identifying potential biomarkers. Method We carried...
The therapeutic challenge of advanced, recurrent, and refractory cervical cancer (CC) needs to develop new molecularly targeted drugs. Rad21 is an important regulatory gene that maintains the correct dissociation sister chromatids during cell mitosis. aim this study was investigate effect on CC. expression in CC intraepithelial neoplasia III significantly increased. Women with rs2289937 C genotype (CC+CT) rs4570 rs4579555 genotypes haplotype 1 (TTTCAGGCGC) were associated risk, while women...
Objective To examine the determinants of a positive visual inspection after acetic acid ( VIA ), including relationship testing for high‐risk human papillomavirus HR‐HPV which is necessary cause cervical cancer. Design A prospective cohort study. Setting Three clinical sites in rural China. Population total 7541 women aged 25–65 years. Methods All underwent VIA, DNA testing, by two tests performed on both clinician‐ and self‐collected specimens, HPV E6 oncoprotein testing. Those any test...
The aim of the study was to evaluate performance a folate receptor-mediated tumor detection (FRD) assay for cervical high-grade lesions.A total 1504 patients with abnormal cytology and/or positive human papillomavirus (HPV) testing during primary screening from November 2014 August 2015 were enrolled. recruited Peking University People's Hospital and 12 other hospitals. Folate applied in all before colposcopy compare rate, sensitivity, specificity, predictive value, negative coincidence rate...
We previously reported that REBACIN effectively eliminates persistent high-risk human papillomavirus (hrHPV) infection. Here, we conducted a prospective multicenter cohort study to evaluate the safety and effectiveness of REBACIN, taking into account factors such as specific hrHPV subtype patient's age.
(Abstracted from Gynecol Oncol 2023;178:8–13) High-risk human papillomavirus (hrHPV) infection is an essential factor in the development of cervical cancer, making timely treatment this important. The number individuals with persistent hrHPV gynecological outpatient setting remains high, and no effective drug has been brought to market.
High-risk human papilloma virus (HPV)-associated cervical cancer is the fourth most common in women worldwide. Current treatments of high-grade squamous intraepithelial lesion (HSIL) cervix are based on invasive surgical interventions, compromising competence and functionality. APRICITY a multicentre, prospective, double-blind, randomised controlled phase 3 study further evaluating efficacy safety Cevira, an integrated drug-delivery light-delivery device for hexaminolevulinate photodynamic...