A5070830488- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Integrated Energy Systems Optimization
- Genital Health and Disease
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Carbon Dioxide Capture Technologies
- Cancer Risks and Factors
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Uterine Myomas and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Climate Change Policy and Economics
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
Qilu Hospital of Shandong University
2016-2025
North China Electric Power University
2017-2024
Shandong University
2005-2024
Guangdong Medical College
2023
Weifang Medical University
2013-2022
Academy of Medical Sciences
2022
Shandong Tumor Hospital
2022
Linzi District People's Hospital
2022
Shandong First Medical University
2022
National University of Singapore
2021
This phase III trial aimed to explore the efficacy and safety of fuzuloparib (formerly fluzoparib) versus placebo as a maintenance treatment after response second- or later-line platinum-based chemotherapy in patients with high-grade, platinum-sensitive, recurrent ovarian cancer.Patients cancer previously treated at least two regimens were assigned (2:1) receive (150 mg, twice daily) matching for 28-day cycles. The primary end points progression-free survival (PFS) assessed by blinded...
Abstract Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and potential target for cancer immunotherapy. In our study, we evaluated the role of checkpoints in progression cervical cancer. Methods The expression CD155 TIGIT tissues was detected using flow cytometry, immunohistochemistry (IHC) gene profiling. vivo vitro experiments have proven that blocking restores ability CD8 + T cells to produce cytokines. Changes NF-κB ERK pathways were western blotting...
Abstract N 6-methyladenosine (m6A) is the most abundant mRNA modification in mammals and it plays a vital role various biological processes. However, roles of m6A on cervical cancer tumorigenesis, especially macrophages infiltrated tumor microenvironment cancer, are still unclear. We analyzed abnormal methylation using CaSki THP-1 cell lines, that might influence macrophage polarization and/or function microenvironment. In addition, C57BL/6J BALB/c nude mice were used for validation vivo....
5-Aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) is a possible minimally-invasive treatment for high-grade cervical intraepithelial neoplasia (HSIL). The present study was carried out to assess the effect of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in squamous (CIN2) combined with high-risk human papillomavirus (HR-HPV) infection. In this study, 190 patients CIN2 HR-HPV infection were finally included. They divided into LEEP Group (n=116) PDT (n=74)...
Transforming growth factor (TGF)‑β1 is a key cytokine affecting the pathogenesis and progression of cervical cancer. Tumor‑derived exosomes contain microRNAs (miRNAs/miRs) that interact with cancer stromal cells, thereby contributing to tissue remodeling in tumor microenvironment (TME). The present study was designed clarify how TGF‑β1 affects biological functions through released by cells. Deep RNA sequencing found stimulated cells secrete more miR‑663b‑containing exosomes, which could be...
Taking the emergence of continuous resistance to chemotherapy and evidence that miRNAs are associated with chemoresistance in cancers into consideration, it is significant importance reveal functions for treatment cancer. As a novel tumor suppressor, MiR-634 known induce apoptosis cell which essential tumorigenesis. Herein, we elucidated regulation effects miR-634 gene expression discovery its target proliferation invasion would aid therapeutic apoptosis. result, by targeting mTOR signal...
Cervical cancer chemotherapy calls for the efficiently delivery of anticancer drug into cells by nanoparticles. In this study, folate (FA) modified, cisplatin (CIS)-loaded nanostructured lipid carriers (NLCs) were constructed and evaluated.FA containing polyethylene glycol (PEG)-distearoylphosphatidylethanolamine (DSPE) (FA-PEG-DSPE) was synthesized. FA-PEG-DSPE CIS-loaded NLCs (FA-CIS-NLCs) prepared. Their particle size, zeta potential, encapsulation efficiency (EE) in vitro behavior...
Cancer cells undergo metabolic changes that support their malignant growth. These are often associated with increased expression of the rate-limiting glycolytic enzyme hexokinase 2. Hexokinase 2 is an catalyzes conversion glucose to glucose-6-phosphate. In this study, we utilized Gene Expression Profiling Interactive Analysis (GEPIA) database analysis and clinical sample find was highly expressed in cervical cancer. Furthermore, found high cancer demonstrated a positive correlation tumor...
Protein regulator of cytokinesis‑1 (PRC1) is a microtubule‑associated factor involved in cytokinesis. Recent studies have indicated that PRC1 overexpression tumorigenesis multiple types human cancer. However, the expression, biological functions and prognostic significance ovarian cancer not yet been clarified. In this study, it was confirmed mRNA protein expression levels were upregulated high‑grade serous carcinoma (HGSOC) tissues, particularly patients without breast susceptibility gene...
Colposcopy is widely used to detect cervical cancer, but developing countries lack the experienced colposcopists necessary for accurate diagnosis. Artificial intelligence (AI) being in computer-aided diagnosis (CAD) systems. In this study, we developed and validated a CAD model based on deep learning classify lesions colposcopy images.Patient data, including clinical information, images, pathological results, were collected from Qilu Hospital. The study included 15,276 images 7,530 patients....
Background Cervical cancer has the second-highest mortality rate among malignant tumors of female reproductive system. Immune checkpoint inhibitors such as programmed cell death protein 1 (PD-1) blockade are promising therapeutic agents, but their efficacy when combined with neoadjuvant chemotherapy (NACT) not been fully tested, and how they alter tumor microenvironment comprehensively elucidated. Methods In this study, we conducted single-cell RNA sequencing using 46,950 cells from nine...