A5100372506- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Dysphagia Assessment and Management
- Pelvic and Acetabular Injuries
- Genetic and phenotypic traits in livestock
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Esophageal and GI Pathology
- Musculoskeletal pain and rehabilitation
- Microtubule and mitosis dynamics
- Machine Learning in Bioinformatics
- Mathematical Inequalities and Applications
- Retinal Imaging and Analysis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Artificial Intelligence in Healthcare and Education
- Orthopaedic implants and arthroplasty
- Urological Disorders and Treatments
The First People's Hospital of Guiyang
2021-2025
Inner Mongolia University
2019-2025
First Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Shanghai Electric (China)
2025
Chongqing Cancer Hospital
2025
Chongqing University
2004-2025
Baoshan College
2024
The Eighth Hospital of Xi'an
2022-2024
Chinese University of Hong Kong
2019-2024
Nanjing University of Information Science and Technology
2024
Retinal vessel segmentation with deep learning technology is a crucial auxiliary method for clinicians to diagnose fundus diseases. However, the approaches inevitably lose edge information, which contains spatial features of vessels while performing down-sampling, leading limited performance fine blood vessels. Furthermore, existing methods ignore dynamic topological correlations among feature maps in framework, resulting inefficient capture channel characterization. To address these...
OBJECTIVE: To establish a new cesarean scar ectopic pregnancy clinical classification system with recommended individual surgical strategy and to evaluate its efficacy in treatment of pregnancy. METHODS: This retrospective cohort study included patients Qilu Hospital Shandong, China. From 2008 2015, were determine risk factors for intraoperative hemorrhage during treatment. Univariable analysis multivariable logistic regression analyses used explore the independent (300 mL or greater)...
Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal differentiation. Prior work established doublesex- mab-3-related transcription factor 1 (Dmrt1) as conserved transcriptional regulator male sexual Here we investigate the role Dmrt1 in mouse spermatogonial (SSC) homeostasis. We find that maintains SSCs during steady state spermatogenesis, where it regulates expression Plzf, another...
Objectives: Sacral nerve stimulation (SNS) is a potential treatment for constipation refractory to standard therapies. However, there have been no randomized controlled studies examining its efficacy. In patients with slow transit constipation, we evaluated the efficacy of suprasensory and subsensory SNS compared sham, in prospective, 18-week randomized, double-blind, placebo-controlled, two-phase crossover study. The primary outcome measure was proportion who, on more than 2 days/week at...
In this study, iron selenide nanoparticles (FeSe2) were synthesized and applied in Fenton-like reactions for degradation of pollutants. It was found that FeSe2 exerts excellent catalytic reactivity toward different oxidants including peroxymonosulfate (PMS), peroxydisulfate, H2O2, which can degrade a wide range pollutants such as 2,4,4′-trichlorobiphenyl, bisphenol A, sulfamethoxazole, chlortetracycline, perfluorooctanoic acid, with the efficiency TOC removal reaching 55–95 20.3–50.9%,...
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism endothelial cells emerges as a promising option achieve vascular normalization antagonize progression. Herein, we demonstrated that salvianic acid A (SAA) played pivotal role in contributing tumor-bearing mice, thereby improving delivery effectiveness chemotherapeutic agent. SAA was capable inhibiting glycolysis strengthening junctions human umbilical vein (HUVECs) exposed...
Data-driven machine learning, as a promising approach, possesses the capability to build high-quality, exact, and robust models from ophthalmic medical data. Ophthalmic data, however, presently exist across disparate data silos with privacy limitations, making centralized training challenging. While ophthalmologists may not specialize in learning artificial intelligence (AI), considerable impediments arise associated realm of research. To address these issues, we design develop FedEYE,...
Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time target range (TTR) for BP since on risk stiffness midlife remains unclear. The purpose this study was to determine independent association TTR systolic (SBP) from adulthood. This used data ongoing cohort Hanzhong Adolescent Hypertension Study. SBP-TTR assessed over 36 years, ranges SBP defined as 90th 95th percentile age, sex, height childhood, 110 130...
As the era of big data approaches, conventional digital computers face increasing difficulties in performance and power efficiency due to their von Neumann architecture. a result, there is recently tremendous upsurge investigations on brain‐inspired neuromorphic hardware with high parallelism improved efficiency. Memristors are considered as promising building blocks for realization artificial synapses neurons can therefore be utilized construct neural networks. Here, review provided...
In mammals, a key transition in spermatogenesis is the exit from spermatogonial differentiation and mitotic proliferation entry into spermatocyte meiosis. Although several genes that regulate this have been identified, how it controlled coordinated remains poorly understood. Here, we examine role male gametogenesis of Doublesex-related gene Dmrt6 (Dmrtb1) mice find plays crucial directing germ cells through mitotic-to-meiotic cell transition. DMRT6 protein expressed late spermatogonia....
Abstract Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota its metabolites, clarify their correlations with inflammation, oxidation, leaky clinical profiles underlying in schizophrenia (ScZ). Methods Serum stool specimens from ScZ inpatients (ScZ-Ag, 25 cases) without (NScZ-Ag, were collected. Systemic oxidation biomarkers determined by ELISA, 16S rRNA sequencing, short-chain fatty...
Abstract Both O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory mechanisms that maintain cellular homeostasis function in response to various stress conditions. Abnormalities O-GlcNAcylation ER-phagy have been documented a wide variety of human pathologies. However, whether or is involved the pathogenesis intervertebral disc degeneration (IDD) largely unknown. In this study, we investigated...
Importance Adolescent idiopathic scoliosis (AIS) is the most common pediatric spinal disorder. Routine physical examinations by trained personnel are critical to diagnose severity and monitor curve progression in AIS. In presence of concerning malformation, radiographs necessary for diagnosis or follow-up, guiding further management, such as bracing correction moderate malformation spine surgery severe malformation. If left unattended, progressive deterioration occurs two-thirds patients,...
Abstract Metastasis remains a major cause of mortality and poor prognosis in breast cancer patients. Anti-metastatic therapies are great need to achieve optimal clinical outcome Panax Notoginseng Saponins (PNS) has previously been shown inhibit metastasis mouse. Here the potential anti-metastatic effect one chemical compounds PNS, ginsenoside Rd (Rd), was further evaluated mouse mammary carcinoma 4T1 cells. The results revealed that treatment dose-dependently suppressed cell migration...
In several parts of China, there have been a large number hydropericardium syndrome (HPS) outbreaks caused by serotype 4 fowl adenovirus (FAdV-4) in broiler chickens since 2015. These outbreak-associated FAdV-4 strains were distinct from previous circulating which did not lead to severe HPS outbreaks. To better understand the molecular epidemiology currently FAdV for effective diagnosis and treatment HPS, we isolated 12 different regions central China investigated their characteristics...
Aims Atherosclerosis is the primary cause of cardiovascular diseases and stroke. The current study evaluated interventional effects a naturally occurring compound Notoginsenoside R1 (NR1) on atherosclerosis in ApoE−/− mice. Methods Results atherosclerotic lesion was significantly alleviated by NR1 treatment this attenuation marked reduction lipid deposition, fibrosis oxidative stress. Increased serum levels GSH SOD decreased level MDH were observed NR1-treated also CHO, TG, ox-LDL increased...
Background/Aims: Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on paclitaxel-based chemotherapy. In this study, we aimed to evaluate whether miR-34a attenuates chemoresistance paclitaxel by regulating target genes associated with drug resistance. Methods: We used data from The Cancer Genome Atlas compare expression levels in (PC) tissues normal tissues. effects of inhibition overexpression PC proliferation were evaluated vitro...
Scutellaria baicalensis Georgi is an extensively used medicinal herb for the treatment of hypertension in traditional Chinese medicine. Baicalin most abundant flavone compound present and endothelium-dependent vascular activities baicalin have been suggested. However, pharmacological implications mechanisms under hypertensive conditions remain to be investigated. The current study examined blood pressure-lowering effect a spontaneously rat (SHR) model. Moreover, were investigated conditions....
Over the past few decades, seeding strategies for solution crystallization processes have been developed various applications, and significant improvements in crystal quality process robustness achieved. Here a systematic review of techniques from preparation characteristics seed crystals to application instances is presented. First, dependence strategy on tuning purpose secondary nucleation illustrated discussed combination with instances. Next, specific targets such as systems oiling out,...