A5101535679- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- X-ray Spectroscopy and Fluorescence Analysis
- Ginseng Biological Effects and Applications
- Advanced X-ray Imaging Techniques
- Radiation Dose and Imaging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Radioactive Decay and Measurement Techniques
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Retinal Diseases and Treatments
- Medicinal Plant Pharmacodynamics Research
- Nuclear Physics and Applications
- Immune Cell Function and Interaction
- Cardiac Ischemia and Reperfusion
- Advanced Radiotherapy Techniques
- Scientific Measurement and Uncertainty Evaluation
- Natural product bioactivities and synthesis
- Cardiac Structural Anomalies and Repair
- Biomarkers in Disease Mechanisms
- Connexins and lens biology
- Inflammasome and immune disorders
- Natural Compounds in Disease Treatment
- Barrier Structure and Function Studies
- Radiation Shielding Materials Analysis
Yueyang Hospital
2014-2025
Shanghai University of Traditional Chinese Medicine
2014-2025
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
National Institute of Metrology
2019-2020
Jiangsu Institute of Metrology
2019
Shanghai University
2014-2015
Xi'an Peihua University
2013
Institute of High Energy Physics
1992
It is widely recognized that inflammation plays a critical role in cardiac hypertrophy and heart failure. However, clinical trials targeting cytokines have shown equivocal effects, indicating the need for deeper understanding of precise inflammatory cells Leukocytes from human subjects rodent model failure were characterized by marked reduction expression Klf2 mRNA. Using mouse angiotensin II–induced nonischemic dysfunction, we showed neutrophils played an essential pathogenesis progression...
Abstract Metastasis remains a major cause of mortality and poor prognosis in breast cancer patients. Anti-metastatic therapies are great need to achieve optimal clinical outcome Panax Notoginseng Saponins (PNS) has previously been shown inhibit metastasis mouse. Here the potential anti-metastatic effect one chemical compounds PNS, ginsenoside Rd (Rd), was further evaluated mouse mammary carcinoma 4T1 cells. The results revealed that treatment dose-dependently suppressed cell migration...
Aims Atherosclerosis is the primary cause of cardiovascular diseases and stroke. The current study evaluated interventional effects a naturally occurring compound Notoginsenoside R1 (NR1) on atherosclerosis in ApoE−/− mice. Methods Results atherosclerotic lesion was significantly alleviated by NR1 treatment this attenuation marked reduction lipid deposition, fibrosis oxidative stress. Increased serum levels GSH SOD decreased level MDH were observed NR1-treated also CHO, TG, ox-LDL increased...
Photoreceptor death leads to vision impairment in several retinal degenerative disorders. Therapies protecting photoreceptor from degeneration remain be developed. Anti-inflammation, anti-oxidative stress, and neuroprotective effects of celastrol have been demonstrated a variety disease models. The current study aimed investigate the protective effect celastrol. Bright light-induced BALB/c mice was used, morphological, functional, molecular changes retina were evaluated absence presence...
Intestinal pathophysiological alterations have recently been revealed to be implicated in the pathogenesis of hypertension, necessitating further investigations better understand intestinal effects anti-hypertensive drugs. The current study thus investigated pharmacological implications a commonly used first-line angiotensin II type 1 receptor blocker, candesartan cilexetil, on barrier impairment and gut dysbiosis spontaneously hypertensive rats (SHRs). results that treatment protected...
Left ventricular hypertrophy leads to heart failure, a serious medical condition associated with high rates of hospitalization and mortality. Limited success the existing pharmacological treatments necessitates development mechanisms-based new therapies better control progression from left failure. The current work investigated potentials mechanisms naturally occurring cinnamic acid in treatment vitro findings reveal that attenuates hypertrophic responses mitochondrial dysfunction...
Background Hypertension is the most common cause of pathological left ventricular hypertrophy, a condition causally associated with debilitating heart failure and cardiovascular events in hypertensive patients. It well recognized that disease burden hypertension-linked remains unabated existing treatments. New therapies controlling hypertrophy are thus required to decelerate or prevent development failure. Our previous study has demonstrated cinnamic acid, naturally occurring monocarboxylic...
Background Under hyperglycemic conditions, impaired intestinal barrier integrity leads to heightened level of inflammation, playing important roles in driving diabetic complications. Emerging evidence supports the implications neutrophil extracellular traps (NETs) pathogenesis diabetes. However, whether NETs contribute hyperglycemia-linked impairment remains be investigated. Moreover, baicalin, major chemical component Scutellaria baicalensis Georgi, is equipped with twofold protective and...
Main text An indirect comparison of the standards for reference air kerma rate 192 Ir high dose (HDR) brachytherapy sources National Institute Metrology (NIM), China, and Bureau International des Poids et Mesures (BIPM) was carried out at NIM in October 2024. The result, based on calibration coefficients a transfer standard expressed as ratio BIPM rate, is 1.0027 with combined uncertainty 0.0045. To reach main this paper, click Final Report . Note that which appears Appendix B key database...
Panax Notoginseng Saponins (PNS) is the major class of active constituents notoginseng, a natural product extensively used as therapeutic agent in China. Tumor when accompanied by cardiovascular disorders poses greater challenge for clinical management given paradoxical involvement angiogenesis, therefore gaining increased research attention. This study aim to investigate effects PNS and its activity components mouse model tumor complicated with myocardial ischemia. complexed ischemia was...
Our previous study has reported that the plasma microRNA-505 (miR-505) is elevated in hypertensive patients. However, pathophysiological significance of miR-505 hypertension remains to be elucidated. Hypertension not only a vascular disorder, but also an inflammatory condition. The current therefore aims further investigate implications hypertension-associated and changes. In vivo experiments reveal level spontaneously rats angiotensin II-infused mice. addition, agomir treatment results...
Photoreceptor degeneration is a central pathology of various retinal degenerative diseases which currently lack effective therapies. Antioxidant and anti-inflammatory activities are noted for Panax notoginsenoside saponins (PNS) related saponin compound(s). However, the photoreceptor protective potentials PNS or compound(s) remain unknown. The current study revealed that protected against loss in bright light-exposed BALB/c mice. Combination ginsenoside Rb1 Rd, two major compounds PNS,...
Purpose: Owing to the important mechanistic implications in pathogenesis of cardiac hypertrophy and heart failure, inflammation has been proposed as a druggable target for treatment failure. Ginseng is widely used medicinal herb cardiovascular disorders. As one major chemical components ginseng, ginsenoside Rb1 (Rb1) contributes effects ginseng. Meanwhile, anti-inflammatory activity also documented. The current work aims further delineate pharmacological hypertrophy. Methods: Angiotensin II...
Chitosan/collagen composite nanofibrous scaffold has been greatly concerned in recent years for its favorable physicochemical properties which mimic the native extracellular matrix (ECM) both morphologically and chemically. In a previous study, we had successfully fabricated chitosan/collagen by electrospinning. present further investigate biocompatibility of such nanofiber to be used as scaffolds vascular tissue engineering. The porcine iliac artery endothelial cells (PIECs) were employed...
Hypertension is a chronic disease with high prevalence, and associated risk of vascular premature death. Traditional Chinese medicine has been administered to treat hypertension for many years. In the present study, effects Yiqi Huaju formula (YQ; compound used in traditional herbal medicine) were observed salt‑sensitive hypertension, which was induced by high‑salt high‑fat (HSF) diet potential mechanism investigated. YQ prepared from five plant extracts dissolved normal sodium chloride...