A5100372521- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Genomics and Phylogenetic Studies
- Energy, Environment, Economic Growth
- Respiratory viral infections research
- Allergic Rhinitis and Sensitization
- Medicinal Plant Pharmacodynamics Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Machine Learning in Bioinformatics
- Air Quality and Health Impacts
- RNA Research and Splicing
- Virology and Viral Diseases
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Plant Disease Resistance and Genetics
Qingdao University
2025
Yueyang Hospital
2011-2025
Shanghai University of Traditional Chinese Medicine
2011-2025
Anhui University of Finance and Economics
2020-2025
Dalian University of Technology
2025
Qingdao Women and Children's Hospital
2025
Qilu Hospital of Shandong University
2018-2024
Northwestern Polytechnical University
2017-2024
Chengdu University of Technology
2021-2024
Inner Mongolia University
2022-2024
Cervical cancer screening by combined cytology and HPV test has reduced the incidence of cervical cancer, but cytological lacks a higher sensitivity while testing possesses lower specificity. Most patients with invasive are treated radiotherapy. However, insensitivity to radiotherapy leads poor efficacy. Illumina Methylation EPIC 850k Beadchip was used for genomic screening. We detected methylation SEPT9 mRNA expression in different tissues using methylation-specific PCR qRT-PCR. Then CCK8,...
Abstract Circular RNAs (circRNAs) participate in gene regulation and malignant tumor progression, including uterine cervical cancer (CC). In this study, the expression profile of circRNAs CC was detected using circRNA microarrays. Then, we selected hsa_circ_0000745 for further examination from significantly dysregulated circRNAs. Proliferation assays, Transwell quantitative reverse transcription polymerase chain reaction, western blot analysis tumorigenesis tests vivo were used to validate...
Drug resistance is an important factor for treatment failure of gastric cancer. N6 -methyladenosine (m6 A) the predominant mRNA internal modification in eukaryotes. The roles m6 A drug cancer remains unclear. In present study, methylated RNA level was significantly decreased while expression demethylase fat mass and obesity-associated protein (FTO) obviously elevated cisplatin-resistant (SGC-7901/DDP) cells. Knockdown FTO reversed cisplatin SGC-7901/DDP cells both vitro vivo, which...
Abstract N 6-methyladenosine (m6A) is the most abundant mRNA modification in mammals and it plays a vital role various biological processes. However, roles of m6A on cervical cancer tumorigenesis, especially macrophages infiltrated tumor microenvironment cancer, are still unclear. We analyzed abnormal methylation using CaSki THP-1 cell lines, that might influence macrophage polarization and/or function microenvironment. In addition, C57BL/6J BALB/c nude mice were used for validation vivo....
Plasmodiophora brassicae, the causal agent of clubroot disease Brassica crops, is widespread in world. Quantitative trait loci (QTLs) for partial resistance to 4 different isolates P. brassicae (Pb2, Pb4, Pb7, and Pb10) were investigated using a BC1F1 population from cross between two subspecies rapa, i.e. Chinese cabbage inbred line C59-1 as susceptible recurrent parent turnip ECD04 resistant donor parent. The BC1F2 families assessed under controlled conditions. A linkage map constructed...
Impaired intestinal barrier plays an important role in the pathogenesis of hypertension primarily through promoting development chronic low-grade inflammation. Baicalin is major flavonoid component Scutellaria baicalensis Georgi, a medicinal plant commonly used for treatment inflammatory disorders and traditional Chinese medicine. However, it remains to be elucidated whether baicalin alleviates hypertension-associated impairment. The current study thus investigated effects on integrity,...
Mounting evidences have indicated that long noncoding RNAs (lncRNAs) play pivotal roles in human diseases, especially cancers. Recently, TINCR was proposed to be involved tumor progression. However, its role colorectal cancer (CRC) remains elusive. In our study, we found SP1-induced significantly upregulated CRC tissues and cell lines. Moreover, cox multivariate survival analysis revealed high an independent predictor of poor overall (OS). Functionally, knockdown obviously suppressed cells...
Sepsis is a systemic inflammatory response syndrome caused by an infection in the body, and accompanying acute kidney injury (AKI) common complication of sepsis. It associated with increased mortality morbidity. Forsythia Fructus, dried fruit suspensa (Thunb.) Vahl, commonly used traditional Chinese medicine.This study aimed to elucidate protective effect Forsythiaside A (FTA) on sepsis-induced AKI downregulating apoptotic responses, exploring its underlying mechanism.Septic was induced...
Intestinal pathophysiological alterations have recently been revealed to be implicated in the pathogenesis of hypertension, necessitating further investigations better understand intestinal effects anti-hypertensive drugs. The current study thus investigated pharmacological implications a commonly used first-line angiotensin II type 1 receptor blocker, candesartan cilexetil, on barrier impairment and gut dysbiosis spontaneously hypertensive rats (SHRs). results that treatment protected...
Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification and controls many aspects RNA metabolism including gene expression. However, mechanisms by which m6A regulates cell- condition-specific expression are still poorly understood, partly due to a lack tools capable identifying sites that regulate under different conditions. Here we develop m6A-express, first algorithm for predicting regulation (m6A-reg-exp) from limited methylated immunoprecipitation sequencing...
Abstract N 6 -methyladenosine (m A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA biology. While m A modifications during numerous viral infections have been described, the role in innate immune response remains unclear. Here, we examined cellular epitranscriptomes Pseudomonas aeruginosa and herpes simplex virus type 1 (HSV-1), lipopolysaccharide (LPS) stimulation to identify A-regulated genes. We showed that significant portion genes including many...
Left ventricular hypertrophy leads to heart failure, a serious medical condition associated with high rates of hospitalization and mortality. Limited success the existing pharmacological treatments necessitates development mechanisms-based new therapies better control progression from left failure. The current work investigated potentials mechanisms naturally occurring cinnamic acid in treatment vitro findings reveal that attenuates hypertrophic responses mitochondrial dysfunction...
Advancements in sequencing have enabled the assembly of numerous sheep genomes, significantly advancing our understanding link between genetic variation and phenotypic traits. However, genome East Friesian (Ostfriesisches Milchschaf), a key high-yield milk breed, remains to be fully assembled. Here, we constructed near-complete gap-free using PacBio HiFi, ultra-long ONT Hi-C sequencing. The resulting spans approximately 2.96 Gb, with contig N50 length 104.1 Mb only 164 unplaced sequences....
Metformin (Met) is the recommended first-line therapeutic drug for type 2 diabetes mellitus (T2DM) and exerts protective effects on β-cell damage. Ferroptosis, a new form of cell death, associated with pancreatic islet injury in patients T2DM. However, Met treatment against damage through ferroptosis modulation remain under-reported. This study investigated vivo using two different diabetic mouse models, namely, low-dose streptozotocin (STZ) high-fat diet (HFD)-induced mice db/db mice....