A5103801489- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Modular Robots and Swarm Intelligence
- Cellular Automata and Applications
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Topological and Geometric Data Analysis
- Acute Lymphoblastic Leukemia research
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Corneal Surgery and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- DNA and Biological Computing
- Acupuncture Treatment Research Studies
- Phagocytosis and Immune Regulation
- UAV Applications and Optimization
- Tribology and Lubrication Engineering
- Protein Degradation and Inhibitors
Beijing University of Chinese Medicine
2024-2025
Shanghai University of Traditional Chinese Medicine
2021-2025
Union Hospital
2024-2025
Jilin University
2024-2025
Yueyang Hospital
2021-2025
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
Shandong Provincial Hospital
2018-2024
Shandong University
2011-2024
Henan Institute of Technology
2023-2024
Abstract Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to is unknown. Here we show that lactate receptor (HCAR1) highly enriched in pial fibroblast-like cells line vessels supplying blood brain, pericyte-like along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) angiogenesis. High-intensity interval (5 days weekly for 7 weeks), as well L-lactate subcutaneous...
Abstract Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalin superfamily and plays dual roles in prostaglandins metabolism lipid transport. PTGDS has been involved various cellular processes including tumorigenesis solid tumors, yet its role carcinogenesis contradictory significance hematological malignancies ill-defined. Here, we aimed to explore expression function diffuse large B-cell lymphoma (DLBCL), especially potential inhibitor, AT56, therapy. Remarkable high...
N6-methyladenosine (m6A) has been shown to participate in various essential biological processes by regulating the level of target genes. However, function m6A modification mediated KIAA1429 [alias virus-like methyltransferase-associated protein (VIRMA)] during progression diffuse large B-cell lymphoma (DLBCL) remains undefined.The expression and clinical significance were verified our data. CRISPR/Cas9 deletion, CRISPR/dCas9-VP64 for activating endogenous was used evaluate its function. RNA...
Abstract Metabolic reprogramming is a hallmark of human malignancies. Dysregulation glutamine metabolism essential for tumorigenesis, microenvironment remodeling, and therapeutic resistance. Based on the untargeted metabolomics sequencing, we identified that metabolic pathway was up-regulated in serum patients with primary DLBCL. High levels were associated inferior clinical outcomes, indicative prognostic value In contrast, derivate alpha-ketoglutarate (α-KG) negatively correlated...
Epigenetic alterations play crucial roles in diffuse large B-cell lymphoma (DLBCL). Disturbances lipid metabolism contribute to tumor progression. However, studies epigenetics, especially its critical regulator YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), on regulation DLBCL are unidentified.
Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate role exosomal miR-107 lymphomagenesis and explore its clinical significance. In this study, decreased miR-107, miR-375-3p, upregulated miR-485-3p were detected plasma DLBCL patients showed potential diagnostic value. Downregulated expression...
Background Intracerebral hemorrhage (ICH) is a severe subtype of stroke lacking effective pharmacological targets. Long noncoding RNA (lncRNA) has been confirmed to participate in the pathophysiological progress various neurological disorders. However, how lncRNA affects ICH outcomes acute phase not completely clear. In this study, we aimed reveal relationship lncRNA-miRNA-mRNA following ICH. Method We conducted autologous blood injection model and extracted total RNAs on day 7. Microarray...
Genomic instability is a significant driver of cancer.As the sensor cytosolic DNA, cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway plays critical role in regulating anti-tumor immunity and cell death.However, regulatory mechanisms STING diffuse large B-cell lymphoma (DLBCL) are still undefined.In this study, we reported that sterile alpha motif HD domain-containing protein 1 (SAMHD1) deficiency induced expression inhibited tumor growth DLBCL.High level SAMHD1 was...
Condensin, a family of structural maintenance chromosome complexes, has been shown to regulate compaction and segregation during mitosis. NCAPD3, HEAT-repeat subunit condensin II, plays dominant role in condensin-mediated dynamics but remains unexplored lymphoma. The study aims unravel the molecular function mechanism NCAPD3 diffuse large B-cell lymphoma (DLBCL). expression clinical significance were assessed public database specimens. Chromosome spreads, co-immunoprecipitation (co-IP), mass...
Background Under hyperglycemic conditions, impaired intestinal barrier integrity leads to heightened level of inflammation, playing important roles in driving diabetic complications. Emerging evidence supports the implications neutrophil extracellular traps (NETs) pathogenesis diabetes. However, whether NETs contribute hyperglycemia-linked impairment remains be investigated. Moreover, baicalin, major chemical component Scutellaria baicalensis Georgi, is equipped with twofold protective and...
purpose. A previous report has described the use of eye bank storage cultured human limbal epithelial cells (HLECs) to provide a reliable source tissue for treating stem cell deficiency. In present study, conventional organ culture (OC) and Optisol-GS (Bausch & Lomb, Irvine, CA) HLECs were compared. methods. Three-week HLEC cultures either at 31°C or 23°C stored in 5°C closed container 1 week. Morphology was studied by light microscopy transmission electron microscopy, phenotypic...
The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Multicolor immunohistofluorescence examination cryosections 30 treated, untreated, or antigen-provoked aspirin-tolerant individuals with and nine control subjects revealed that the dominating LTC4S-expressing cells were mast (> 80%), not eosinophils. Whereas 95% expressed high levels LTC4S, only 8-27% low levels. Image analysis a...
Abstract Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential improving the efficacy chemotherapy. Nevertheless, role diffuse large B-cell lymphoma (DLBCL) is still undefined. In this study, we discover that target for treatment DLBCL, and demonstrate inhibitor when used combination with doxorubicin. Pharmaceutical inhibition...