A5100377852- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Protein purification and stability
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Genetic Associations and Epidemiology
- Protein Structure and Dynamics
- Mitochondrial Function and Pathology
- Medicinal Plant Pharmacodynamics Research
- Melanoma and MAPK Pathways
- Cancer Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell death mechanisms and regulation
- Phytochemistry and Biological Activities
- Enzyme Structure and Function
- Microbial Metabolic Engineering and Bioproduction
- Signaling Pathways in Disease
- Bipolar Disorder and Treatment
- Cellular transport and secretion
Central South University
2019-2025
Xiangya Hospital Central South University
2019-2024
Jinzhou Medical University
2022-2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2016-2023
Chinese Academy of Sciences
2016-2023
Chongqing Medical University
2023
Nantong University
2019-2022
Affiliated Hospital of Nantong University
2022
Beijing Shijitan Hospital
2022
Capital Medical University
2022
Background: By providing oxygen, nutrients and metastatic conduits, tumour angiogenesis is essential for cancer metastasis. Cancer cell-secreted microRNAs can be packaged into exosomes are implicated in different aspects of angiogenesis. However, the underlying mechanisms incompletely understood. Methods: The GEPIA database situ hybridization assay were used to analyse expression miR-205 ovarian tissues. Immunohistochemistry was performed examine relationship between microvessel density....
Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumour-associated can development metastasis ovarian by mediating macrophage polarization. However, exact mechanisms underlying communication (OC) during OC progression remain unclear. Here, we demonstrated that high expression miR-205 was associated with...
Clathrin-coated pits are sites of concentration ligand-bound signaling receptors. Several such receptors known to recruit, bind, and activate the heterodimeric phosphatidylinositol-3-kinase, resulting in generation phosphatidylinositol 3,4,5-trisphosphate. We report here that dioctanoyl-phosphatidylinositol-3,4,5-P3 binds specifically saturably soluble AP-2 with greater affinity within assembled coat structures. Soluble D-myo-inositol hexakisphosphate shows converse behavior. Binding bovine...
The BRAF oncoprotein is mutated in about half of malignant melanomas and other cancers, a kinase activating single valine to glutamate substitution at residue 600 (BRAF(V600E)) accounts for over 90% BRAF-mediated cancers. Several BRAF(V600E) inhibitors have been developed, although they harbor some liabilities, thus motivating the development inhibitor options. We report here use an ELISA based high-throughput screen identify family related quinolol/naphthol compounds that preferentially...
Abstract Motivation The ABACUS (a backbone-based amino acid usage survey) method uses unique statistical energy functions to carry out protein sequence design. Although some of its results have been experimentally verified, accuracy remains improvable because several important components the not specifically optimized for design or in contexts other parts method. computational efficiency also needs be improved support interactive online applications consideration a large number alternative...
Head and neck squamous cell carcinoma represents a complex set of neoplasms arising in diverse anatomical locations. The site stage the cancer determine whether patients will be treated with single or multi-modality therapy. HDAC inhibitor LBH589 is effective treating some haematological shows promise for certain epithelial neoplasms. As other human lines, causes up-regulation p21, G2/M cycle arrest, death HNSCC as measured using flow cytometry cDNA microarrays. Global RNA expression studies...
tRNA-derived fragments (tRFs) are 14-40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown that tRFs associated Argonaute (AGO) complexes and inhibit gene expression the same manner as miRNAs. However, there currently no tools for accurately predicting tRF target genes.We used tRF-mRNA pairs identified by crosslinking, ligation, sequencing of hybrids (CLASH) covalent ligation...
Background Intracerebral hemorrhage (ICH) is a severe subtype of stroke lacking effective pharmacological targets. Long noncoding RNA (lncRNA) has been confirmed to participate in the pathophysiological progress various neurological disorders. However, how lncRNA affects ICH outcomes acute phase not completely clear. In this study, we aimed reveal relationship lncRNA-miRNA-mRNA following ICH. Method We conducted autologous blood injection model and extracted total RNAs on day 7. Microarray...
Abstract Cognitive impairment is a frequent and serious problem in patients with various forms of severe mental illnesses (SMI), including schizophrenia (SZ) bipolar disorder (BP). Recent research suggests genetic links to several cognitive phenotypes both SMI the general population. Our goal this study was identify potential genomic signatures functioning veterans illness compare them previous findings for cognition across different populations. Veterans Affairs (VA) Cooperative Studies...
Ulcerative colitis (UC) is a recrudescent and chronic inflammatory disease. Artesunate (ART) has shown its anti-inflammatory antioxidative properties in severe diseases, including UC.The present study investigates the molecular mechanisms for effects of ART on UC, role miR-155 this process.The vitro UC model was established by using lipopolysaccharide (LPS)-induced RAW264.7 cells. For BALB/c mice model, different concentrations/doses were treated once day 7 days. The apoptosis viability...
Herein, we report a successful application of molecular modeling techniques to design two novel peptides with cytotoxicity on tumor cells. First, the interactions between nuclear transport factor 2 (NTF2)-like domain G3BP and SH3 RasGAP were studied by well-designed protocol, which combines homology modeling, protein/protein docking, dynamics simulations, mechanics/generalized born surface area (MM/GBSA) free energy calculations, MM/GBSA decomposition analysis together. Then, based...
This study aimed to investigate the role of BMP2 in hepatocellular carcinoma (HCC) growth and metastasis using a dual approach combining single-cell RNA sequencing (scRNA-seq) bulk RNA-seq.
Summary Targeted therapies for mutant BRAF metastatic melanoma are effective but not curative due to acquisition of resistance. PI 3K signaling is a common mediator therapy resistance in melanoma; thus, the need inhibitors critical. However, testing adherent cultures always reflective their potential vivo. To emphasize this, we compared different specificity two‐ and three‐dimensional (2D, 3D) models show that drug response predictions gain from evaluation using 3D models. Our results...