A5052503443- Mitochondrial Function and Pathology
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Drug Transport and Resistance Mechanisms
- Pharmacology and Obesity Treatment
- Acute Lymphoblastic Leukemia research
- Metabolism, Diabetes, and Cancer
- Acute Myeloid Leukemia Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antioxidant Activity and Oxidative Stress
- Liver Disease and Transplantation
- Adipose Tissue and Metabolism
- Nuts composition and effects
- Pancreatic and Hepatic Oncology Research
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Gestational Diabetes Research and Management
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Drug-Induced Hepatotoxicity and Protection
- Diabetes Management and Education
- Pain Mechanisms and Treatments
Victor Babeș University of Medicine and Pharmacy Timișoara
2021-2025
Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara
2024-2025
Preeclampsia (PE) is a major complication of pregnancy with partially elucidated pathophysiology. Placental mitochondrial dysfunction has been increasingly studied as pathomechanism in both early- and late-onset PE. Impairment respiration platelets recently emerged peripheral biomarker that may mirror organ several acute chronic pathologies. The present study was purported to assess respiratory dys/function placental mitochondria PE pregnancies. To this aim, high-resolution respirometry SUIT...
Background/Objectives: Glycemic variability (GV) is a novel concept in the assessment of quality glycemic control patients with diabetes, its importance emphasized type 1 diabetes. Its adoption clinical practice emerged increased availability continuous monitoring systems. The aim this study to evaluate GV diabetes mellitus (T1DM) and assess associations other parameters used control. Methods: indexes classical markers were analyzed for 147 adult T1DM multicentric cross-sectional study....
The Glucose Management Indicator (GMI) is a biomarker of glycemic control which estimates hemoglobin A1c (HbA1c) based on the average glycemia recorded by continuous glucose monitoring sensors (CGMS). GMI provides an immediate overview patient’s control, but it might be biased sensor wear adherence or sensor’s reading errors. This study aims to evaluate GMI’s performance in assessment and identify factors leading erroneous estimates. In this study, 147 patients with type 1 diabetes, users...
Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent main reason for treatment discontinuation. Mitochondrial dysfunction complex I has been implicated in pathophysiology SAMS. The present study proposed to assess concentration-dependent ex vivo effects three statins on mitochondrial respiration viable human platelets and investigate whether a cell-permeable prodrug succinate (complex II substrate) can...
Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) II (CII) of the electron transport system various animal tissues cell types. The present study, performed human peripheral blood cells, one liver-derived line, primarily aimed at assessing concentration-dependent effects these drugs on...
Diabetes mellitus (DM) is the most severe metabolic disease that reached level of a global pandemic and associated with high cardiovascular morbidity. Statins are first–line lipid–lowering therapy in diabetic patients or without history atherosclerotic disease. Although well tolerated, chronic treatment may result side effects lead to interruption. Mitochondrial dysfunction has emerged as central pathomechanism DM– statin–induced effects. Assessment mitochondrial respiration peripheral...
Diabetes mellitus (DM) is one of the most serious public health problems, involving increasing costs worldwide. The mental state a person with DM varied and ever-changing, such as stress, pressure to always do everything by book, sadness, anger, even denial disease, all these are feelings patients will experience throughout their life.The aim our study was assess presence psychiatric disorders (anxiety, depressive states, paranoid ideation, phobia, obsessive-compulsive disorder) in group...
Background and Objectives: In the last decades there has been an increasing body of research identifying positive correlation between diabetes mellitus (DM) solid malignancies, moreover, having shown DM as independent risk factor for colorectal cancer (CRC). The aim present study was to assess impact on metastatic CRC (mCRC), identify possible predictive factors in successful treatment mCRC. Materials Methods: 468 patients with mCRC were included this retrospective, observational study. A...
Background and Objectives: Type 2 diabetes (T2DM) affects millions across the globe, generating a veritable public health issue through quality-of-life-reducing chronic complications, among which urinary tract infections are most common. A shift in disease managing paradigm from glucose-centered view to concept of cardio-reno-metabolic has uniquely placed SGLT2 inhibitors as viable medication for complex management T2DM its comorbidities. Some concerns have been raised over increased...
Open-heart surgery with cardiopulmonary bypass (CPB) remains the standard approach for complex cardiac pathologies, such as advanced coronary heart disease and severe valvular defects. Platelet dysfunction has been widely reported, both structural functional changes being elicited by CPB circuit. Succinate is a mitochondrial substrate that metabolized through II (CII) but impermeable to cellular membranes when given exogenously. Cell-permeable succinates are novel prodrugs developed support...
Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. In last decades, survival rate of paediatric patients diagnosed with ALL has been significantly improved due to standardised treatment protocols based on risk stratification. Platelet mitochondrial dysfunction recently reported occur in chronic diseases, including malignancies. Permeable succinate (NV118) a novel mitochondria-targeted compound capable alleviate disease and drug-induced dysfunction. It here that ex...