A5100668366- Blood Pressure and Hypertension Studies
- Natural product bioactivities and synthesis
- Cardiovascular Health and Disease Prevention
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Sodium Intake and Health
- Traditional Chinese Medicine Analysis
- Catalytic C–H Functionalization Methods
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant chemical constituents analysis
- Pharmacological Effects and Toxicity Studies
- Phytochemistry and Biological Activities
- Photonic and Optical Devices
- Carbohydrate Chemistry and Synthesis
- Diabetes Management and Research
- Viral gastroenteritis research and epidemiology
- Mechanical and Optical Resonators
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Pancreatic function and diabetes
- Cyclopropane Reaction Mechanisms
- Model Reduction and Neural Networks
- Physics of Superconductivity and Magnetism
Southern University of Science and Technology
2025
Beijing Academy of Quantum Information Sciences
2025
China Medical University
2021-2025
Fuyang Normal University
2022-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking University
2025
Gilead Sciences (United States)
2012-2024
Beijing Institute of Technology
2021-2024
Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting glomerular filtration rate. This study aimed to define transporters involved in secretion, applying that knowledge establish mechanism for xenobiotic-induced effects. The basolateral uptake organic anion transporter OAT2 and cation OCT2 OCT3 were found transport creatinine. At physiologic concentrations, specific activity of was over twofold...
Twenty-five naturally occurring pentacyclic triterpenes, 15 of which were synthesized in this study, biologically evaluated as inhibitors rabbit muscle glycogen phosphorylase a (GPa). From SAR studies, the presence sugar moiety triterpene saponins resulted markedly decreased activity ( 7, 18- 20) or no 21, 22). These saponins, however, might find their value potential natural prodrugs are much more water-soluble than corresponding aglycones. To elucidate mechanism GP inhibition, we have...
ABSTRACT Tenofovir alafenamide (TAF) is a prodrug of tenofovir (TFV) currently in clinical evaluation for treatment HIV and hepatitis B virus (HBV) infections. Since the target tissue HBV liver, hepatic delivery metabolism TAF primary human hepatocytes vitro dogs vivo were evaluated here. Incubation with resulted high levels pharmacologically active metabolite diphosphate (TFV-DP), which persisted cell half-life >24 h. In addition to passive permeability, studies transfected lines suggest...
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East (MERS-CoV) 2012 has generated enormous interest the biodiversity, genomics cross-species transmission potential coronaviruses, especially those from bats, second most speciose order mammals. Herein, we identified a novel coronavirus, provisionally designated Rousettus bat GCCDC1 (Ro-BatCoV GCCDC1), rectal swab samples leschenaulti bats by using pan-coronavirus RT-PCR next-generation sequencing....
The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, transported by membrane transporters, which play major roles in its absorption and disposition. Recently, our laboratory demonstrated that organic transporter 1, OCT1, hepatic uptake metformin, was also primary thiamine, vitamin B1. In this study, we tested reverse, i.e., substrate thiamine transporters (THTR-1, SLC19A2, THTR-2, SLC19A3). Our study...
Abstract Background The triglyceride-glucose index (TyG index) has emerged as a reliable surrogate marker of insulin resistance associated with arterial stiffness. However, most studies were based on cross-sectional design, and few have evaluated the longitudinal impact TyG This study aimed to investigate associations single time point measurement long-term trajectory stiffness in Chinese cohort. Methods Data are derived from Hanzhong Adolescent Hypertension Cohort study. A total 2480...
Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time target range (TTR) for BP since on risk stiffness midlife remains unclear. The purpose this study was to determine independent association TTR systolic (SBP) from adulthood. This used data ongoing cohort Hanzhong Adolescent Hypertension Study. SBP-TTR assessed over 36 years, ranges SBP defined as 90th 95th percentile age, sex, height childhood, 110 130...
Background Inhibition of the transporter-mediated hepatobiliary elimination bile salts is a putative mechanism for liver toxicity observed with some endothelin receptor antagonists (ERAs). Methods Sandwich-cultured human hepatocytes were used to study distribution and accumulation exogenous taurocholate, ERAs endogenous acids. The molecular mechanisms findings in or clinical observations further explored using either vesicular assays (efflux transporters) transfected cell-lines (uptake...
The double 1,3-dipolar cycloaddition of allenoates with nitrilimines has been achieved under mild reaction conditions, affording a variety spirobidihydropyrazoles in moderate to excellent yields diastereoselectivities. diastereoselectively constructs dihydropyrazole moieties and two chiral centers including spiro carbon center.
Palladium-catalyzed [5 + 2] cycloaddition of 2-aryl-2-vinyloxiranes with sulfamate-derived cyclic imines is described. The zwitterionic allylpalladium intermediates act as five-membered synthon to react furnish cycloaddition, giving 1,3-oxazepine derivatives in moderate excellent yields regioselectivities.
Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations individual risk factors from childhood midlife their accumulation over a 30-year span with vascular aging in midlife.Using data ongoing cohort Hanzhong Adolescent Hypertension study, 2180 participants aged 6 18 years at baseline were followed for 30 years. Distinct trajectories systolic blood pressure (SBP), body mass index...
BackgroundLimited data exists on how early-life weight changes relate to metabolic syndrome (MetS) risk in midlife. This study examines the association between long-term trajectories of body mass index (BMI), its variability, and MetS Chinese individuals.MethodsIn Hanzhong Adolescent Hypertension (March 10, 1987–June 3, 2017), 1824 participants with at least five BMI measurements from 1987 2017 were included. Using group-based trajectory modeling, different identified. variability was...
The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in moderate excellent yields enantioselectivities (up 99% ee). Compared previous reactions copper–allenylidenes from benzoxazinanones, the current reaction fused three carbon atoms propargyl moiety into a heterocyclic framework.
A bifunctional phosphine-catalyzed highly enantioselective [2+4] cycloaddition of α-substituted allenoates with (E)-1-benzyl-4-olefinicpyrrolidine-2,3-diones has been achieved, giving pyrrolidin-2-one fused dihydropyran derivatives in moderate to good yields excellent enantioselectivities (up 98% ee). This reaction provides a useful catalytic asymmetric access structural motifs.
An unprecedented [4 + 3] annulation reaction of aza-ortho-quinone methides with arylcarbohydrazonoyl chlorides has been achieved under mild conditions. The underwent a sequential conjugate addition/intramolecular annulation/rearrangement, providing useful method for the synthesis biologically interesting 2,3-dihydro-1H-benzo[e][1,2,4]triazepine.
An enantioselective synthesis of biologically important imidazolidines has been achieved via a tandem [3 + 2] cycloaddition/1,4-addition reaction azomethine ylide and aza-o-quinone methides. With the use this tool, various imidazolidine derivatives are obtained in good yields with excellent diastereoselectivities enantioselectivities.
Inhibition of thiamine transporters has been proposed as a putative mechanism for the observation Wernicke's encephalopathy and subsequent termination clinical development fedratinib, Janus kinase inhibitor (JAKi). This study aimed to determine potential other JAKi inhibit transport using human epithelial colorectal adenocarcinoma (Caco-2) transporter (THTR) overexpressing cells better elucidate structural basis interacting with THTR. Only containing 2,4-diaminopyrimidine were observed...
A once-daily single-tablet antiretroviral regimen containing tenofovir (TFV) disoproxil fumarate, emtricitabine (FTC), elvitegravir (EVG), and cobicistat (COBI) is an approved combination for the treatment of patients infected with HIV. COBI TFV have been reported to interact distinct transporters in renal proximal tubules; while renally eliminated by a glomerular filtration tubular secretion via anion OAT1, OAT3, MRP4, inhibits cation transporters, particularly MATE1, resulting measurable...
Statins are commonly used medications by HIV-1 patients. Elvitegravir/cobicistat/emtricitabine/tenofovir DF is a single tablet regimen for the treatment of HIV. The pharmacokinetic interaction between cobicistat-boosted elvitegravir (EVG/co) and rosuvastatin was evaluated. Breast cancer resistance protein (BCRP) organic anion transporting polypeptide (OATP) 1B1 1B3 inhibition were assessed in vitro. Healthy subjects (N = 12) received dose 10 mg alone combination with EVG/co. Intensive...
Abstract A simple and effective sample preparation process based on miniaturized matrix solid‐phase dispersion was developed for simultaneous determination of phenolic acids (gallic acid, chlorogenic ferulic 3,5‐dicaffeoylqunic 1,5‐dicaffeoylqunic rosmarinic lithospermic salvianolic acid B), flavonoids (kaempferol‐3‐ O ‐rutinoside, calycosin, formononetin), lactones (ligustilide butyllidephthalide), monoterpenoids (paeoniflorin), phenanthraquinones (cryptotanshinone), furans...