A5100715119- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Reproductive tract infections research
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Genital Health and Disease
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
Beijing Tian Tan Hospital
2022-2025
Capital Medical University
2022-2025
Qilu Hospital of Shandong University
2015-2024
Hangzhou Dianzi University
2024
Lanzhou University
2024
Shandong University
2012-2023
Chengdu Center for Disease Control and Prevention
2023
ShanghaiTech University
2023
Peking Union Medical College Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
PRMT5 has been reported to be involved in the processes of tumor progression at various steps. The aim this study was examine role epithelial ovarian cancer (EOC). In study, and Ki-67 expression were examined by immunohistochemistry (IHC) cohorts normal, benign, cancerous tissues. overexpression observed 83.1% (98/118) EOCs, it significantly associated with serous type, poor differentiation, advanced stage, lymph node invasion, presence residual tumor, high ( p<0.05, respectively)....
Overwhelming evidence has demonstrated that the aberrant expression of human trophoblast cell-surface antigen (TROP2) was associated with tumor aggressiveness and poor prognosis in a variety cancers, however roles TROP2 cervical cancer have not been investigated. The purpose our study to elucidate prognostic significance patients determine its effect on progression. Immunohistochemistry assay showed 88.7% (94/106 cases) specimens were positively stained TROP2, overexpression closely related...
Endometrial cancer is the most common gynecologic malignancy, whose incidence rate on rise. However, underlying mechanisms of endometrial are not very clear yet. miRNAs have been considered to be playing important roles in malignant behavior. Here, miR-652 was significantly upregulated cancer, which correlated with shorter overall survival and earlier recurrence. Moreover, overexpression cells promoted proliferation, migration, invasion vitro facilitated tumor growth metastasis vivo. In...
Ovarian cancer is the most lethal gynecologic malignancy in women with an increasing number of cases worldwide. Chemoresistance main obstacle for ovarian treatment during clinical therapy. Previous studies found that programmed cell death 1 ligand (PD-L1) was associated chemoresistance cancer. However, there were little reports about function PD-L1 involved In our study, cisplatin (DDP)-resistant SKOV3 and A2780 lines (SKOV3/DDP A2780/DDP) established. We expression increased miR-34a-5p...
Abstract The purpose of this study is to determine the methylation status Transforming growth factor-beta-inducible gene-h3 (TGFBI) and its correlation with paclitaxel chemoresistance in ovarian cancer. TGFBI was examined cancer control groups by methylation-specific PCR (MSP) bisulfite sequencing (BSP). expression cell viability were compared Quantitative Real-Time PCR, Western Blotting MTT assay before after demethylating agent 5-aza-2'-deoxycytidine (5-aza-dc) treatment 6 lines (SKOV3,...
An accumulated evidence supports that MicroRNAs (miRNAs) have shown a prominent role in pathological processes and different tumor onset. However, to date, the potential functional roles molecular mechanisms by how microRNA-424-5p(miR-424-5p) affects cancer cell proliferation are greatly unclear, especially epithelial ovarian cancer(EOC).In this study, we demonstrated miR-424-5p was significantly down-regulated EOC tissues lines. The level of negatively correlated with size, TNM stage,...
The association between uric acid-albumin ratio (UAR) with different diseases has been evaluated before. However, the UAR spontaneous reperfusion (SR) in patients ST-segment elevation myocardial infarction (STEMI) not explored. STEMI admitted to our department and underwent primary coronary angiography 1st November 2018 31st December 2020 were retrospectively enrolled. divided into SR group non-SR according index results. was by uni-variable multi-variable logistic analysis. Receiver...
The study aimed to confirm that anti-epidermal growth factor receptor (EGFR) monoclonal antibody-conjugated hollow gold nanospheres (anti-EGFR/HGNs) can be selectively uptaken by cervical cancer cells and induce its apoptosis when combined with radiotherapy, as a result enhancing radiosensitivity of cells. HGNs mean diameter 54.6 ± 7.11 nm wall thickness 5.01 2.23 were viewed transmission electron microscopy (TEM). Cell uptake was assayed inductively coupled plasma atomic emission...
Abstract Endometrial cancer (EC) is the sixth most common in women. Since early EC has a good prognosis, identifying methods for diagnosis valuable. Here, we aimed to study role of HDAC6, which been indicated important many kinds cancers, and therapy. First, expression levels HDAC6 tissues cells were measured by qRT-PCR Western blotting, through bioinformatics dual luciferase assays, was found be direct target miR-206. Then, CCK-8, colony formation, wound healing, Transwell assays performed;...
Uterine Leiomyosarcoma (ULMS) is the most lethal gynecologic malignancy with few therapeutic options. Chemoresistance prevails as a major hurdle in treating this malignancy, yet mechanism of chemoresistance remains largely unclear. In study, we identified MELK poor prognostic marker through bioinformatic analysis GEO database. Cellular experiments vitro revealed that played an essential role ULMS cells' and high expression could lead to doxorubicin resistance. mRNA profiling uncovered...
Aim: To develop and validate a deep learning radiomics model, which could predict the lymph node metastases preoperatively in cervical cancer patients. Patients methods: We included cohort of 226 pathological proven operable patients two academic medical institutions from December 2014 to November 2017. Then this dataset was split into training set (n = 176) independent testing 50) randomly. Five radiomic features were selected signature established. then combined these five with...
Background Women with congenital heart disease are considered at high risk for adverse events. Therefore, we aim to establish 2 prediction models mothers and their offspring, which can predict the of events occurred in pregnant women disease. Methods Results A total 318 were included; 213 divided into development cohort, 105 validation cohort. Least absolute shrinkage selection operator was used predictor selection. After validation, multivariate logistic regression analysis develop model....
Abstract Background To investigate distributions of cervical lesions and factors associated with the severity in high-risk HPV (hr-HPV) positive women atypical squamous cells undetermined significance (ASC-US) cytology. Methods Clinical information 250,000 who underwent cytological test was collected from January 2012 to 2019. The association between hr-HPV genotypes, viral load, ages, were analyzed hr-HPV-positive/ASC-US women. Results 3459 enrolled this study. Overall, 43.51% ASC-US had...
Abstract Platelets are reprogrammed by cancer via a process called education, which favors development. The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for detection. This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses 167 healthy controls from nine medical centers (China, n = 3; Netherlands, 5; Poland, 1) between September 2016 May 2019. main outcomes...