A5100348982- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- AI in cancer detection
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- RNA modifications and cancer
- Immune cells in cancer
- Galectins and Cancer Biology
Shandong First Medical University
2016-2025
Jiangnan University
2017-2025
Yangzhou University
2022-2025
Qingdao University
2025
State Key Laboratory of Food Science and Technology
2017-2025
Shandong Tumor Hospital
2015-2024
Gansu University of Traditional Chinese Medicine
2023-2024
Shandong University
2015-2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Rationale: Immune checkpoint inhibitors (ICIs) against the PD-1/PD-L1 pathway showed limited success in non-small cell lung cancer (NSCLC) patients, especially those with activating epidermal growth factor receptor (EGFR) mutations. Elucidation of mechanisms underlying EGFR-mediated tumor immune escape and development effective therapeutics are urgently needed. Immunoglobulin-like transcript (ILT) 4, a crucial immunosuppressive molecule initially identified myeloid cells, is enriched solid...
<i>Background/Aims:</i> Although numerous studies have explored the mechanisms regulating enzyme activity of NADPH oxidase in diabetic nephropathy (DN), little information is available for contribution microRNAs (miRNAs) to regulation expression. Therefore, present study was test whether miRNAs importantly contribute NOX4 expression, a major catalytic subunit under hyperglycemia. <i>Methods:</i> Diabetic rats were induced by streptozotocin. miRNA microarray, Western...
The aim of this study was to evaluate the effects three different kinds oligosaccharides (a fructo-oligosaccharide (FOS) formulation consisting 95% FOS (FOS95); a galacto-oligosaccharide (GOS) 90% GOS (GOS90) and an isomalto-oligosaccharide (IMO) IMO (IMO90)) at dosages 0.8, 4 g per d kg bw 8 on composition activity microbiota in gut mice with constipation induced by loperamide. Oligosaccharides were intragastrically administered specific pathogen-free BALB/c once day for 17 days. Feces...
Constipation is one of the most common gastrointestinal complaints worldwide. This study was performed to determine whether Bifidobacterium adolescentis exerts inter-strain differences in alleviating constipation induced by loperamide BALB/c mice and analyze main reasons for these differences. underwent gavage with B. (CCFM 626, 667, 669) once per day 17 days. The primary outcome measures included related indicators, secondary were basic biological characteristics strains, concentration...
Constipation is a disorder that affects people of all ages. Previous study showed Bifidobacterium spp. altered the faecal concentrations short-chain fatty acids (SCFAs) while relieving constipation. Therefore, we speculated SCFAs might relieve We evaluated constipation-related indicators, SCFA levels and microbiota constipated mice were fed acylated starches derived from specific for 1 month. It confirmed application resolved issue absorption in small intestine by measuring concentration...
Carcinoma‑associated fibroblasts (CAFs) are the major components of mesenchymal cells in inflammatory tumor microenvironment. They involved epithelial‑mesenchymal transition (EMT) and chemotherapy resistance by directly contacting with cancer or secretory cytokines. In present study, we examined role CAFs induction EMT ovarian cancer. Primary cells, normal (NFs) were isolated from fresh tissue cultured for immunohistochemistry studies. Enzyme‑linked immunosorbent assay (ELISA) was used to...
CCFM16 raises Firmicutes and Clostridia then SCFAs levels to relieve constipation. Several taxa in Clostridiales prevent from properly functioning.
Constipation is a major health concern worldwide, requiring effective and safe treatment options. This study mainly focused on three species nine strains of bifidobacteria from different sources to their abilities relieve constipation induced by loperamide in BALB/C mice. By monitoring constipation-related indicators, it was found that only Bifidobacterium longum (B. longum) relieved constipation, which indicated had inter-species differences relieving constipation. Furthermore, through the...
Functional constipation (FC) is a gastrointestinal disorder with high incidence, and it seriously affects patients' physical mental health. Several studies have shown that the gut microbiome associated FC, but these produced inconsistent findings, few reflecting relationship between metabolites. This study used 16S rRNA microbial genomics non-target metabolome based on liquid chromatography-mass spectrometry to analyze microbiota composition serum metabolic profiles of 30 FC patients 28...
Abstract Treatment options for patients with relapsed extensive-stage small cell lung cancer (ES-SCLC) remain scarce. This study aims to evaluate the efficacy and safety of combining anlotinib sintilimab plus chemotherapy as a second line or later therapy ES-SCLC patients. is phase II clinical trial (ChiCTR2100049390) conducting at Shandong Cancer Hospital. Patients received least one prior systemic treatment were enrolled. The design involved combination (sintilimab, anlotinib,...
Immunoglobulin‐like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 over‐expressed in human non‐small cell lung cancer (NSCLC) cells and involved tumour evasion via an unknown mechanism. In this report, we demonstrate increases expression co‐inhibitory molecule B7‐H3 through PI3K/AKT/mTOR signalling. primary NSCLC tissues, a significant positive relationship observed between expression. ILT4/B7‐H3 co‐expression...
Constipation, which seriously affects living quality of people, is a common gastrointestinal disease. The engagement the intestinal flora in development symptoms constipation has been frequently hypothesized. In this study, constipated mice induced by loperamide were used to investige alleviation Bifidobacteria. Bifidobacteria was sorted out according their adhesive properties into two groups. One group combined multiple strains Bifidobacterium with adhesion property (CMB1), other without...
Increasing researches have confirmed the relationship between slow-transit constipation and gut microbiota dysbiosis. Many population animal experiments identified probiotics as effectors for relief of symptoms, but specific mechanism remains unclear. In this intervention study, Lactobacillus rhamnosus strains isolated from five different sources were administered to mice with loperamide-induced constipation, impacts these on constipation-related indicators evaluated. All L. found improve...
Abstract Kawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause acquired heart in children developed countries. Interleukin (IL)-37, one IL-1 family members, a natural suppressor inflammation caused by activation innate and adaptive immunity. However, detailed roles IL-37 KD are largely unclear. Sera from patients with displayed level was significantly decreased compared...
Irritable bowel syndrome with diarrhea and functional are both disorders that cause chronic diarrhea. Chronic is closely related to daily life the psychological condition of in patients, probiotics can play a significant role alleviating some research. Lactobaccilus plantarum CCFM1143 relieve mice caused by enterotoxigenic Escherichia coli (ETEC); however, its clinical effects remain unclear. This study aimed assess as therapy for patients. Fifty-five patients were randomly assigned into...
<italic>B. bifidum</italic> had intraspecies differences in relieving constipation. It can promote intestinal peristalsis by gastrointestinal active peptides. Specially, FXJCJ32M2 may the expression of AQP8 and VIPR1 through gut microbiota modulation.
Microorganisms consume and transform dissolved organic matter (DOM) into various forms. However, it remains unclear whether the ecological patterns drivers of DOM chemodiversity are analogous to those microbial communities. Here, a large-scale investigation is conducted along Chinese coasts resolve intrinsic linkages among complex intertidal pools, communities environmental heterogeneity. The abundance molecular formulae best fits log-normal distribution follows Taylor's Law. Distance-decay...
Abstract Background Immunotherapy has significantly improved survival of esophageal squamous cell cancer (ESCC) patients, however the clinical benefit was limited to only a small portion patients. This study aimed perform deep learning signature based on H&E-stained pathological specimens accurately predict PD-1 inhibitors in ESCC Methods patients receiving from Shandong Cancer Hospital were included. WSI images histological included collected, and randomly divided into training (70%)...
Abstract Histone deacetylases ( HDAC s)‐mediated epigenetic mechanisms play critical roles in the homeostasis of histone acetylation and gene transcription. inhibitors have displayed neuroprotective properties animal models for various neurological diseases including Alzheimer's disease ischaemic stroke. However, some studies also reported that enzymes exert protective effects several pathological conditions stress. The mixed results indicate specific each protein different diseased states....
Bifidobacterium longum S3 influenced the intestinal barrier and immunity, water channel protein expression, neurotransmitter GI active peptide levels by affecting immunity modulating changes in of fatty acid metabolites, especially LCFAs.