A5101967311- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- Lipid metabolism and disorders
- Phytochemistry and Biological Activities
- Tissue Engineering and Regenerative Medicine
- Pediatric health and respiratory diseases
- Liver Disease and Transplantation
- Congenital heart defects research
- Cancer Cells and Metastasis
- Bioactive Natural Diterpenoids Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- Natural Compound Pharmacology Studies
- Cancer, Lipids, and Metabolism
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Bioactive natural compounds
Henan University
2018-2025
Shanghai University of Traditional Chinese Medicine
2021-2024
Shandong First Medical University
2022-2024
Shandong University
2007-2024
Second Hospital of Shanxi Medical University
2020-2024
Shanxi Medical University
2020-2024
Shandong Tumor Hospital
2022-2024
Nantong University
2024
Michigan Medicine
2020-2024
St. Paul University Philippines
2024
Rationale: Immune checkpoint inhibitors (ICIs) against the PD-1/PD-L1 pathway showed limited success in non-small cell lung cancer (NSCLC) patients, especially those with activating epidermal growth factor receptor (EGFR) mutations. Elucidation of mechanisms underlying EGFR-mediated tumor immune escape and development effective therapeutics are urgently needed. Immunoglobulin-like transcript (ILT) 4, a crucial immunosuppressive molecule initially identified myeloid cells, is enriched solid...
Although nonthyroidal illness syndrome is considered to be associated with adverse outcome in ICU patients, the performance of thyroid hormone levels predicting clinical patients unimpressive. This study was conducted assess prognostic value complete indicators (free triiodothyronine (FT3), total triiodothyronine; free thyroxine, thyroid-stimulating and reverse triiodothyronine) unselected patients.A 480 consecutive without known diseases were screened for eligibility followed up during...
Background. The red cell distribution width (RDW) in ICU patients has never been investigated. Methods. A total of 602 consecutive were prospectively enrolled. We collected each patient's base-line characteristics including the Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, RDW, C-reactive protein (CRP). primary outcome for this analysis was mortality, secondary length stay hospital (TLSH). Potential predictors analyzed possible association with outcomes. Results. There...
AIM:To study the relationship between polymorphisms in some cytokines and outcome of hepatitis B virus (HBV) C (HCV) infection. METHODS:Samples were obtained from 203 patients infected with HBV and/or HCV while donating plasma 1987, 74 controls a rural area North China.Antibodies to or antigens detected by enzyme-linked immunoassay.The presence viral particles serum was determined nested reverse-transcriptase polymerase chain reaction (PCR).Hepatocellular injury, as revealed alanine...
Drug nephrotoxicity has high fatality rates and complications. To study this conditional, traditionally, Gentamicin (GM) is used to induce acute injury establish a nephrotic syndrome model. Baicalin, flavonoid derived from baicalin with potent anti-inflammatory antioxidant activity, been treat various inflammatory diseases. This aims investigate the process of baicalin-2-ethoxyethyl ester (BAE) synthesis its therapeutic effect on GM-induced kidney (AKI). Briefly, was processed by reactions...
Hepatocellular carcinoma (HCC) is a common and aggressive human malignancy. An imperative demand present for better understanding of the functions regulations immune system how they affect HCC pathogenesis. Recently, group interleukin 9 (IL-9)-producing CD4+ T cells, termed Th9 has been described in mice humans with both tumour-inhibiting as well tumour-promoting effects. The specific roles cells are not entirely understood. Here, we examined frequencies IL-9-producing patients. We found...
To investigate the incidence rates of candidemia in hospitalized patients and to identify differences risk factors with Candida albicans non-C. guilliermondii candidemia.Non-immunosuppressed, non-neutropenic inpatients diagnosed after admission were included this retrospective observational study at a tertiary academic hospital China.During period (January 2009 December 2011), 238 eligible had episodes an rate 5.4%. Of these patients, 29.8% due C. albicans, 27.7% parapsilosis, 16.4%...
Purpose: Hesperidin has anti-inflammatory and anti-oxidant stress effects, but its functions in chronic obstructive pulmonary disease (COPD) remains unknown. This study analyzed the role of hesperidin COPD mice, aiming to provide a basis for application.Materials methods: Mice were injected with cigarette smoke extract (CSE) construct models then treated budesonide or hesperidin. Hematoxylin-eosin (HE) TUNEL assays used observe pathological changes cell death lung tissue. The levels...
Abstract Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human ortholog receptor, leukocyte (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages during by binding with ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific...
Abstract To provide evidence for optimization of multi-kinase inhibitors (MKIs) use in the clinic, we public database to describe and evaluate electrolyte disorders (EDs) related various MKIs treated renal cell carcinoma. We analyzed spontaneous reports submitted Food Drug Administration Adverse Events Reporting System (FAERS) an observational retrospective manner. Selecting disorders' adverse events multikinase (axitinib, cabozantinib, lenvatinib, pazopanib, sunitinib, sorafenib). used Odds...
Abstract Background Patients receiving PD-(L)1 inhibitors frequently encounter unusual side effects known as immune-related adverse events (irAEs). However, the correlation of irAEs development with clinical response in small cell lung cancer (SCLC) is unknown. Method This retrospective study enrolled 244 stage IV SCLC patients who from 3 centers. The objective rate (ORR), disease control (DCR), progression-free survival (PFS), and overall (OS) were evaluated. Results 140 (57%) experienced...
The aim of this study is to assess whether preoperative serum interleukin-6 (IL-6) can predict recurrence hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). association between IL-6 levels and HCC following curative hepatectomy in 146 patients with chronic HBV infection was determined. Patients were divided into groups based on the presence or absence recurrence. Serum compared groups, level greatest tumor dimension also analyzed. Receiver operating characteristics (ROC)...
Glaucoma is an optic neuropathy and a major cause of blindness globally. Trabecular meshwork cells are important in maintaining aqueous humor flow, the dysfunction which tends to induce glaucoma. As regulators gene expression, microRNAs may be crucial regulating trabecular cells. The present study aimed reveal effect microRNA‑93 (miR‑93) on glaucoma (GTM) cell apoptosis. expression levels miR‑93 were compared between human (HTM) GTM was inhibited increased by transfecting with lentivirus...
Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of cancer shows high genomic instability, but underlying mechanisms causing this phenotype are still largely unknown. Here, we report that upon DNA damage, SPOP phosphorylated at Ser119 by ATM serine/threonine kinase, which potentiates binding to homeodomain-interacting kinase 2 (HIPK2), resulting a nondegradative ubiquitination HIPK2. This...
Recently shown to regulate cardiac development, the secreted axon guidance molecule SLIT3 maintains its expression in postnatal heart. Despite known cardiovascular system after birth, SLIT3's relevance function state remains unknown. As such, objectives of this study were determine myocardial sources and evaluate functional role regulating response pressure overload stress. We performed vitro studies on cardiomyocytes tissue samples from patients vivo investigation with ROBO1 (roundabout...
Abstract Antiangiogenic therapy targeting VEGF‐A has become the standard of first‐line for non‐small cell lung cancer (NSCLC). However, its clinical response rate is still less than 50%, and most patients eventually develop resistance, even when using combination with chemotherapy. The major cause resistance activation complex bypass signals that induce angiogenesis tumor progression. Therefore, exploring novel proangiogenic mechanisms developing promising targets are crucial improving...
Abstract Introduction The performance of N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) to predict clinical outcomes in ICU patients is unimpressive. We aimed assess the prognostic value NT-proBNP, CRP or combination both unselected medical patients. Methods A total 576 consecutive were screened for eligibility followed up during stay. collected each patient's baseline characteristics including Acute Physiology Chronic Health Evaluation II (APACHE-II)...