A5108004216- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Multiple and Secondary Primary Cancers
- Helicobacter pylori-related gastroenterology studies
- Urinary Bladder and Prostate Research
- Toxoplasma gondii Research Studies
- Head and Neck Cancer Studies
- Wnt/β-catenin signaling in development and cancer
- Cytomegalovirus and herpesvirus research
- PI3K/AKT/mTOR signaling in cancer
- Advanced Image Fusion Techniques
Shaanxi Provincial People's Hospital
2019-2024
Weifang Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2022
Shandong Center for Disease Control and Prevention
2022
Second Affiliated Hospital of Jilin University
2021
Xidian University
2015-2017
University of Florida
2017
Chinese Academy of Sciences
2016
Shanghai Institute of Materia Medica
2016
Shenyang 242 Hospital
2014
Thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) is a highly aggressive disease that nosologically related to but distinct from non-small cell lung cancer (SD-NSCLC). No standard treatment guidelines were established for SD-UT. This research explored the efficacy of different treatments in SD-UT, and prognostic, clinicopathologic genomic difference between SD-UT SD-NSCLC.Information 25 22 SD-NSCLC patients diagnosed treated Fudan University Shanghai Cancer Center January, 2017...
Non-Hodgkin lymphoma (NHL) is a common B/NK/T cell lymphoma. We collected detailed data about the incidence and mortality of NHL from Global Burden Disease (GBD) Study in 2017 extensively assessed disease burden at global level also analysed its current trends according to sex, age, socio-demographic index (SDI), country region.By obtaining relevant 2017, estimated annual percentage changes (EAPCs) age-standardized rate (ASR) were calculated assess mortality.Globally, ASR was increased while...
Abstract Background Patients receiving PD-(L)1 inhibitors frequently encounter unusual side effects known as immune-related adverse events (irAEs). However, the correlation of irAEs development with clinical response in small cell lung cancer (SCLC) is unknown. Method This retrospective study enrolled 244 stage IV SCLC patients who from 3 centers. The objective rate (ORR), disease control (DCR), progression-free survival (PFS), and overall (OS) were evaluated. Results 140 (57%) experienced...
Background: Platelet (PLT) and red blood cell (RBC) have been demonstrated to play a critical role in inflammatory processes. This study aimed evaluate the association of PLT RBC related parameters with disease activity rheumatoid arthritis (RA) patients, also investigate these indices differentiating among RA patients different activity. Methods: Clinical data from were retrospectively analyzed. divided into inactive group active according DAS28-CRP. The relationship between counts-related...
A novel series of tetrahydroprotoberberine derivatives (THPBs) were designed, synthesized, and evaluated as selective α1A-adrenergic receptors (AR) antagonists for the treatment benign prostatic hyperplasia. On basis pharmacophore model marketed drug silodosin, THPBs modified by introducing an indole segment into their core scaffolds. In calcium assays, 7 out 32 compounds displayed excellent antagonistic activities against α1A-ARs, with IC50 less than 250 nM. Among them, compound (S)-27 had...
HOXD1, HOXD3, and HOXD4 are members of the HOXD genes family related to tumorigenesis tumor. However, whether HOXDs (1, 3, 4) have a crucial role across pan-cancer is still unknown. expressions were analyzed using public databases in 33 types tumors. The UCSC Xena website was carried out investigate relationship between expression progress cancers. biological functions HOXD3 tested by colony forming, transwell, wound healing, xenograft assay vitro vivo. GSEA used identify associated cancer...
MicroRNAs (miRNAs) play crucial roles in tumorigenesis and tumor progression. miR-561 has been reported to be downregulated gastric cancer affects cell proliferation metastasis. However, the role underlying molecular mechanism of human non-small lung (NSCLC) remain unknown need further elucidated. In this study, we discovered that expression was NSCLC tissues lines. The overexpression inhibited cycle G 1 /S transition induced apoptosis. inhibition facilitated suppressed inversely correlated...
(+)-Dihydromethysticin was recently identified as a promising lung cancer chemopreventive agent, while (+)-dihydrokavain completely ineffective. A pilot in vivo structure–activity relationship (SAR) explored, evaluating the efficacy of its analogs blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term O6-methylguanine and long-term adenoma formation tissues A/J mice. Both results revealed cohesive SARs, demonstrating that methylenedioxy functional group DHM is essential...
Abstract Background Although RET‐tyrosine kinase inhibitors (RET‐TKIs) are the preferred first‐line therapy for advanced RET‐arranged NSCLC, most patients cannot afford them. In this population, bevacizumab, immunotherapy, and chemotherapy commonly used regimens. However, optimal scheme beyond RET‐TKIs has not been defined in setting. Methods This retrospective study included 86 stage IV NSCLC harboring RET rearrangement from six cancer centers between May 2017 October 2022. RET‐TKIs,...
This study aims to evaluate the relationship between age, period, and birth cohort with incidence trends of Nasopharyngeal Carcinoma (NPC) in Hong Kong, make projections through 2030 parse drivers incidence.Using data from Kong Cancer Registry, we used an age-period-cohort model uniquely estimate effects on NPC projections. We further assessed using a validated decomposition algorithm.From 1991 2020, crude age-standardized rates decreased significantly. The net drifts showed significant...
Abstract The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and exert critical functions in early embryonic development, as well various adult processes. Furthermore, dysregulation of genes is implicated genetic diseases, heart disease, cancers. In this comprehensive overview, we primarily focused on HOXA1-4 their associated diseases. Emphasis was placed elucidating impact abnormal expression these highlighting significance maintaining optimal health involvement...
Pancreatic cancer remains one of the chief contributors to related deaths on a global scale, with its diagnosis often associated poor prognosis and high mortality. Accumulating literature continues highlight role aberrant DNA methylation in relation pancreatic progression. Integrated bioinformatics approaches characterization methylated-differentially expressed genes (MeDEGs) were employed enhance our understanding potential underlying molecular mechanisms this cancer. We initially...
Objective: To understand the incidence and economic burden of herpes zoster among aged in Laiwu district, Jinan city. Methods: Retrospective cohort study was conducted 5 communities District, City from July to September, 2019. A total 8 300 residents born before 1, 1959 ≥60 years old were included investigation. At same time, an survey carried out 220 cases who developed after 2017. questionnaire used collect information on HZ, comparisons about older people with different characteristics....
e20560 Background: Immunochemotherapy combinations have been the mainstream first-line standard treatment of advanced non-small cell lung cancer (NSCLC), wherein concurrent chemotherapy and immunotherapy are conventionally fixed to an established dosing regimen. Few studies had suggested remarkable impact timing on immunochemotherapy combined therapy. However, this issue has not addressed in NSCLC cohort. Methods: This study was a retrospective analysis 532 patients with adenocarcinoma...
To elucidate the historical trends, underlying causes and future projections of esophageal cancer incidence in Hong Kong.
This study provides a comprehensive analysis of endometrial cancer incidence trends in Hong Kong over the past three decades. It aims to evaluate impact demographic shifts and epidemiological factors, including age, birth cohort, diagnosis period, on rates. The also projects future cases up 2030 assesses contributions these factors using detailed decomposition approach.
Objective To evaluate the efficacy of composite skin grafts consisting allogeneic acellular dermal matrix and autologous scalp in repair defects after excision giant pigmented nevi children.Methods Eighteen children with were included this study.All patients received nevi.The repaired using razor-thin 10 from June 2009 to October 2012 (test group),and thin or intermediate-thickness 8 March 2006 May (control group).Donor site healing time,skin graft survival rate,and degree scar proliferation...
Aiming at the difficulty in X-ray focusing, small field of view and low sensitivity for imaging, a spherically collimated counting imaging method was proposed based on concept single-pixel camera. The spatial star maps that are sparse airspace were measured under function binary observation matrix, reconstructed rapidly by use TVAL3 algorithm. Finally, series simulations designed to evaluate performance reconstruction Peak Signal Noise Ratio (PSNR), Bhattacharyya Coefficient Pearson...
The burden of stomach cancer remains high in Hong Kong. We sought to evaluate the associations age, period, and birth cohort with changing trend incidence provide projections through 2030.We performed an age-period-cohort analysis up 2030 using data from Kong Cancer Registry. Additionally, we used a population decomposition algorithm assess drivers number incident cases Kong.Among 26,813 patients, 1994 2018, age-standardized rate decreased for both sexes. increased age was highest those aged...