A5101599176- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
First Affiliated Hospital of Xi'an Jiaotong University
2012-2024
Jinyintan Hospital
2024
Huazhong University of Science and Technology
2024
Xi'an Jiaotong University
2005-2019
Osaka National Hospital
2019
First Hospital of Xi'an
2003-2011
Hypoxia is known to promote malignant progression and induce chemoresistance in cancer. However, the exact mechanisms driving hypoxia induced malignance remain elusive. We found that with exposure hypoxic condition, hepatocellular carcinoma (HCC) cells experienced epithelial-mesenchymal transition (EMT), increased cell migration invasion, exhibited high resistance chemotherapy. demonstrated hypoxia-induced EMT were accompanied by HIF-1α expression activation of Akt. could be blocked PI3K...
Abstract: Resistance to cisplatin-based therapy is a major challenge in the control of lung cancer progression. However, underlying mechanisms remain largely unclear. Autophagy closely associated with resistance therapy, but function autophagy cisplatin treatment still controversial. Here, we investigated whether was involved adenocarcinoma and further elucidated molecular mechanisms. Cisplatin-refractory cells increased autophagic vacuole formation detected by monodansylcadaverine staining....
Malignant melanoma is one of the most common malignancies. Its incidence grows rapidly at an annual rate 3−5%. Although remains low in China, it has increased rapidly, with approximately 20,000 new cases reported each year. The mortality also been increasing rapidly; contrast, although western countries, its basically unchanged and does not rise along escalation prevalence. Thus, there still a wide gap between China Western countries diagnosis treatment melanoma. Melanoma become diseases...
Background Anlotinib is an oral tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor, fibroblast platelet‐derived and stem cell receptor (c‐Kit). In the phase III ALTER‐0303 trial (Clinical Trial Registry ID: NCT 02388919), anlotinib significantly improved overall survival versus placebo in advanced non‐small lung cancer patients who had received at least two previous chemotherapy epidermal receptor/anaplastic lymphoma targeted therapy regimens. This study...
Non-Hodgkin lymphoma (NHL) is a common B/NK/T cell lymphoma. We collected detailed data about the incidence and mortality of NHL from Global Burden Disease (GBD) Study in 2017 extensively assessed disease burden at global level also analysed its current trends according to sex, age, socio-demographic index (SDI), country region.By obtaining relevant 2017, estimated annual percentage changes (EAPCs) age-standardized rate (ASR) were calculated assess mortality.Globally, ASR was increased while...
While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV from 150-gene panel using very low amount of ctDNA. First, read depth-based estimation without paired blood sample was developed cfDNA data healthy people were used to build normal (PoN) model. Then, silico vitro simulations...
The CXCR4 and Nrf2 signaling pathways are abnormally activated in response to cellular stress various types of human cancers. In this study, we examined the expression colorectal cancer (CRC) tissue specimens investigated their correlation with patient clinicopathologic characteristics. We determined 76 CRC paired normal by immunohistochemistry real-time PCR. found that protein mRNA transcript levels were significantly higher than tissues, while expressions increased tissues compared distant...
Cinnamomum zelanicum is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, copper nanoparticles were synthesized using aqueous extract zelanicum. CuNPs characterized different techniques such as EDX, FE-SEM, XRD, and FT-IR. FE-SEM results confirm spherical morphology for with size 19.55 to 69.70 nm. For investigating antioxidant property CuNPs, DPPH test was used presence butylated hydroxytoluene positive control. To survey...
Metastasis is the main cause of colon cancer-related deaths. RBP-Jκ involved in cancer development, but its function metastasis still unclear. Tumour-associated macrophages are cell components tumour microenvironments. Here, we aimed to determine and underlying mechanisms for modulating interactions between tumour-associated macrophages. Through bioinformation analysis, found that was overexpressed tissues associated with advanced phenotypes, macrophage infiltration shorter survival overall...
Globally, colorectal cancer (CC) is the third leading cause of mortality associated with cancer. Natural killer (NK) cells are a major class that responsible for eliminating tumor and cytokine production. NK cell-mediated production interferon gamma (IFN-γ) has antiviral, immunoregulatory anti-tumor properties. IL-15 important in linking inflammation For instance, promotes humoral immune responses to inhibit growth. inhibits colitis-associated colon carcinogenesis by inducing antitumor...
Gastric cancer is a common and highly lethal malignancy in the world, but its pathogenesis remains elusive. In this study, we focus on biological functions of CDK-associated Cullin1 (CAC1), novel gene cullin family, gastric cancer, which may help us to further understand origin malignancy.The AGS MGC803 cell lines GES-1 mucosa line were selected for study. At first, CAC1 expressions those examined by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) western...
5524 Background: The effectiveness of immune checkpoint inhibitors for treating patients with advanced cervical cancer or platinum-resistant recurrent ovarian (PROC) has been demonstrated in clinical studies. However, the current treatment options have not fully met needs these patients. Since 2021, a Phase Ib/IIa trial was conducted China to assess safety and efficacy PM8002, bispecific antibody that targets both PD-L1 VEGF-A, as monotherapy solid tumors. Preliminary data presented at...
Abstract The 2024 updates of the Chinese Society Clinical Oncology (CSCO) Guidelines for diagnosis and treatment colorectal cancer emphasize standardizing in China, highlighting latest advancements evidence‐based medicine, healthcare resource access, precision medicine oncology. These address disparities epidemiological trends, clinicopathological characteristics, tumor biology, approaches, drug selection patients across diverse regions backgrounds. Key revisions include adjustments to...
To analyse the prognostic factors in 165 colorectal patients aged > or =70.One hundred and sixty-five elderly with cancer diagnosed by histology were entered into retrospective study between 1994 2001. Patients given optimal operation alone, chemotherapy after operation, alone according to tumor stage, histology, physical strength, co-morbid problems. Survival rate was calculated Kaplan-Meier method, compared meaningful variances Log-rank method. Prognostic analyzed Cox regression.The...