A5100391008- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Protein Degradation and Inhibitors
- COVID-19 and healthcare impacts
- melanin and skin pigmentation
- Sexual function and dysfunction studies
- Hair Growth and Disorders
- COVID-19 epidemiological studies
- Urinary Bladder and Prostate Research
- Cardiac tumors and thrombi
- Chemotherapy-induced cardiotoxicity and mitigation
- Genetic factors in colorectal cancer
- COVID-19 diagnosis using AI
- Gastrointestinal Tumor Research and Treatment
- Dermatology and Skin Diseases
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Kidney Stones and Urolithiasis Treatments
- Dermatological and COVID-19 studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
Zhongnan Hospital of Wuhan University
2014-2024
Wuhan University
2014-2024
Huazhong University of Science and Technology
2020-2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Union Hospital
2020-2024
Jinyintan Hospital
2024
Chinese PLA General Hospital
2024
State Key Laboratory of Kidney Diseases
2024
Yulin University
2024
Coronavirus disease 2019 (COVID-19) is an emerging infectious that first appeared in Wuhan, China, and quickly spread throughout the world. We aimed to understand relationship between diabetes mellitus prognosis of COVID-19.
Abstract A recently developed pneumonia caused by SARS-CoV-2 has quickly spread across the world. Unfortunately, a simplified risk score that could easily be used in primary care or general practice settings not been developed. The objective of this study is to identify triage severe COVID-19 patients. All and critical adult patients with laboratory-confirmed on West campus Union Hospital, Wuhan, China, from 28 January 2020 29 February were included study. Clinical data laboratory results...
Dietary risk has always been a major factor for colorectal cancer (CRC). However, the contribution of dietary factors to CRC at level region, gender, and age not fully characterized. Based on Global Burden Disease (GBD) 2019 study, death rates, age-standardized mortality rates (ASDRs), estimated annual percentage changes (EAPCs) were calculated assess trends attributable over past 30 years. Globally, cases increased 1,085,797 in 2019, number deaths attributed 365,752 representing...
Background Population aging is a pivotal trend observed globally, and the exposure to heavy metals can exacerbate process lead kidney damage. However, impact of combined metal on renal function among older individuals remains elusive. Our study employs machine learning techniques delve into effects underlying mechanisms mixed population. Methods This extracted comprehensive data from National Health Nutrition Examination Survey (NHANES) conducted between 2015 2020. A total 3,175 participants...
Abstract Various substances in the blood plasma serve as prognostic indicators of progression COVID-19. Consequently, multi-omics studies, such proteomic and metabolomics, are ongoing to identify accurate biomarkers. Cytokines chemokines, which crucial components immune inflammatory responses, play pivotal roles transition from mild severe illness. To determine relationship between cytokines COVID-19, we used four study cohorts perform a systematic cytokine levels patients with different...
China has a quarter of all patients with multidrug-resistant tuberculosis (MDRTB) worldwide, but less than 5% are in quality treatment programmes. In before-and-after study we aimed to assess the effect comprehensive programme provide universal access diagnosis, treatment, and follow-up for MDRTB four Chinese cities (population 18 million).We designated city-level hospitals each city diagnose treat MDRTB. All smear-positive pulmonary diagnosed Center Disease Control (CDC) clinics were tested...
Objectives As early prediction of severe illness and death for patients with coronavirus disease 2019 (COVID-19) is important, we aim to explore the clinical value laboratory indicators in evaluating progression prognosis COVID-19. Design Retrospective cohort study. Setting Hospital-based study China. Participants Adult COVID-19 from December 15, March 2020. End point Disease severity mortality. Methods Clinical data 638 were collected compared between non-severe groups. The predictive...
ABSTRACT COVID-19, caused by SARS-CoV-2, is an acute self-resolving disease in most of the patients, but some patients can develop a severe illness or even death. To characterize host responses and identify potential biomarkers during progression, we performed longitudinal transcriptome analysis for peripheral blood mononuclear cells (PBMCs) collected from 4 COVID-19 at different time points symptom onset to recovery. We found that PBMCs stages exhibited unique characteristics. SARS-CoV-2...
A recently identified type of pneumonia, referred to as coronavirus disease 2019 (COVID‑19), which is caused by severe acute respiratory syndrome coronavirus‑2, has rapidly spread worldwide. Lymphopenia and a proinflammatory cytokine storm frequently occur in patients with COVID‑19. However, the best our knowledge, no specific immunomodulatory therapy for COVID‑19 been reported date. In present retrospective case‑control study, potential therapeutic effect recombinant human interleukin‑2...
Methylated SDC2 and TFPI2 are widely used for colorectal cancer (CRC) detection. However, they often miss some CRCs, which directly diminishes the sensitivity. Further investigations of underlying mechanisms leading to missed samples will facilitate developing more eligible methylation markers.CRC from TCGA GEO datasets were divided into three groups, High-methylation/ High-methylation (HH), High-methylation/Low-methylation (HL), Low-methylation/Low-methylation (LL) according status...
Abstract Background Vernonia anthelmintica (L.) willd is a traditional urgur herb in China for long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth C57BL/6 mice. We conducted this study investigate the hair-growth effects of AVE stressed mice and its possible mechanism action. Methods The hair-follicle were examined by vivo vitro study. exposed male chronic restraint stress induce murine inhibition. histological analysis, immunofluorescence Ki67 cytokeratin...
Abstract Our study aims to explore changes in bladder contractility and the phosphodiesterase type 5 (PDE5) signalling pathway response partial outlet obstruction (PBOO). A surgically induced male rat PBOO model human obstructed tissues were used. Histological examined by H&E Masson's trichrome staining. Bladder strip was measured via organ bath. The expressions of nitric oxide synthase (NOS) isoforms, PDE5, muscarinic cholinergic receptor (CHRM) isoforms PDE4 detected RT‐PCR Western...
In the early stage of coronavirus disease 2019 (COVID-19), most cases are identified as mild or moderate illnesses. Approximately 20% hospitalised patients become severe critical at middle late disease. The predictors and risk factors for prognosis in those with remain to be determined. Of 694 COVID-19, 231 disease, who were 10 hospitals Wenzhou nearby counties China, enrolled this retrospective study from 17 January 20 March 2020. outcomes these included progression mild/moderate illness...
Abstract Background Many risk factors have emerged for novel 2019 coronavirus disease (COVID-19). It is relatively unknown how these collectively predict COVID-19 infection risk, as well a severe (i.e., hospitalization). Methods Among aged adults (69.3 ± 8.6 years) in UK Biobank, data was downloaded 4,510 participants with 7,539 test cases. We baseline from 10-14 years ago, including demographics, biochemistry, body mass, and other factors, antibody titers 20 common to rare infectious...
Stress has been demonstrated to play an important role in hair follicle function and the pathogenesis of some disorders. The central hypothalamic-pituitary-adrenal (HPA) axis is activated by stress stimuli, synthesizes releases various components eventually induces recurrence peripheral diseases. Our aim compare different responses under exposure among mouse strains, detect involvement HPA after growth melanogenesis. In this study, we exposed strains (C57BL/6, CBA/J, C3H/HeN, BALB/c ICR) a...
Abstract Background Endometrial Cancer (EC) is one of the most prevalent malignancies that affect female population globally. In context immunotherapy, Tumor Mutation Burden (TMB) in DNA polymerase epsilon (POLE) subtype this cancer holds promise as a viable therapeutic target. Methods We devised method known NEM-TIE to forecast TMB status patients with endometrial cancer. This approach utilized combination Network Evolution Model, Transfer Information Entropy, Clique Percolation (CP)...
Abstract To explore how alterations in the phosphodiesterase type 5 (PDE5) signalling pathway and oxidative stress correlate with changes expression of relaxation contraction molecules erectile dysfunction (ED) corpus cavernosum smooth muscle (CCSM) spontaneously hypertensive rats (SHR). In this study, SHR Wistar‐Kyoto (WKY) were used. Erectile function was determined by apomorphine test electrical stimulation (ES) cavernous nerve. Masson's trichrome staining confocal microscopy performed....
Although overall colorectal cancer (CRC) cases have been declining worldwide, there has an increase in the incidence of CRC among individuals younger than 50 years old, which is associated with distant metastasis (DM) and poor prognosis.Young-onset patients' postoperative data were collected from Surveillance, Epidemiology, End Results (SEER) database between January 2010 December 2015. Data SEER divided into early stage advanced according to whether chemoradiotherapy was recommended...
The relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function risk of cardiovascular diseases (CVDs) in patients with new-onset AL, provide data on management strategies for AL. We retrospectively collected characteristics, echocardiography, biochemical blood indicators (e.g., myocardial enzymes) from 408 patients, 200 103 coronary artery disease (CAD), 105 controls January 1, 2015 August 31,...
Our goal was to assess the impact of prior cancer history on prognosis extranodal NK/T-cell lymphoma (ENKTCL). We searched SEER database retrospectively enroll patients with ENKTCL. The effects overall survival (OS) and disease-specific (DSS) were analyzed using Cox model. A total 691 included, whom 54 (7.8%) had histories cancer. most common solid malignancy bone/soft tissue sarcoma. Most secondary ENKTCL cases occurred within 5-9 years following first diagnosis. Radiotherapy chemotherapy...