A5008858438- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 diagnosis using AI
- Neonatal Health and Biochemistry
- Pancreatitis Pathology and Treatment
- Renin-Angiotensin System Studies
- Biomarkers in Disease Mechanisms
- Single-cell and spatial transcriptomics
- Celiac Disease Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Biosensors and Analytical Detection
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adipose Tissue and Metabolism
- Sepsis Diagnosis and Treatment
Guangzhou Eighth People's Hospital
2020-2024
Guangzhou Medical University
2020-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2013-2018
Sun Yat-sen University
2013-2018
<b>In discharged survivors with COVID-19, impairment of diffusion capacity is the most common abnormality lung function, followed by restrictive ventilatory defects, which are both associated severity disease</b>https://bit.ly/2yUaBaT
The emerging COVID-19 caused by SARS-CoV-2 infection poses severe challenges to global public health. Serum antibody testing is becoming one of the critical methods for diagnosis patients. We investigated IgM and IgG responses against nucleocapsid (N) spike (S) protein after symptom onset in intensive care unit (ICU) non-ICU 130 blood samples from 38 patients were collected. levels specific N S detected ELISA. A series collected along disease course same patient, including 11 ICU 27...
ABSTRACT We report temporal patterns of viral shedding in 94 laboratory-confirmed COVID-19 patients and modelled infectiousness profile from a separate sample 77 infector-infectee transmission pairs. observed the highest load throat swabs at time symptom onset, inferred that peaked on or before onset. estimated 44% could occur first symptoms index. Disease control measures should be adjusted to account for probable substantial pre-symptomatic transmission.
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Background Antiviral therapies against the novel coronavirus SARS-CoV-2, which has caused a global pandemic of respiratory illness called COVID-19, are still lacking. Methods Our study ( NCT04252885 , named ELACOI), was an exploratory randomized (2:2:1) controlled trial assessing efficacy and safety lopinavir/ritonavir (LPV/r) or arbidol monotherapy for treating patients with mild/moderate COVID-19. Findings This successfully enrolled 86 COVID-19 34 randomly assigned to receive...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some disease 2019 (COVID-19) patients. The reason for the recurrent positivity of test and potential public health concern due to this occurrence are still unknown. Here, we analyzed viral data clinical manifestations 289 domestic Chinese COVID-19 patients found that 21 individuals (7.3%) were readmitted hospitalization detection SARS-CoV-2 discharge. First, experimentally confirmed...
Abstract Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of without pre-existing metabolic-related diseases, found new-onset insulin resistance, hyperglycemia, decreased HDL-C these patients. Mechanistically, SARS-CoV-2 infection increased the expression RE1-silencing transcription factor (REST), which modulated secreted metabolic factors including myeloperoxidase, apelin,...
Background: Coronavirus disease 2019 (COVID-19) has been a global pandemic disease, with more than 4 million cases and nearly 300,000 deaths. Little is known about COVID-19 in patients chronic obstructive pulmonary (COPD). We aimed to evaluate the influence of preexisting COPD on progress outcomes COVID-19. Methods: This was multicenter, retrospective, observational study. enrolled 1,048 aged 40 years above, including 50 998 without COPD, confirmed via high-throughput sequencing or real-time...
Severe COVID-19 is associated with profound lymphopenia and an elevated neutrophil to lymphocyte ratio. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay analyze T (TCR) B cell receptor (BCR) repertoires. Surprisingly, TCR repertoires were markedly diminished during the early onset of severe disease but recovered convalescent stage. Monitoring could serve as indicative biomarker predict progression recovery. Panoramic concurrent...
Abstract To investigate the dynamic changes of Krebs von den Lungen‐6 (KL‐6) among patients with coronavirus disease 2019 (COVID‐19) and role KL‐6 as a noninvasive biomarker for predicting long‐term lung injury, clinical information laboratory tests 166 COVID‐19 were collected, correlation analysis between other parameters was conducted. There 17 (10.2%, 17/166) severe/critical 149 (89.8%, 149/166) mild in our cohort. Serum significantly higher than (median 898.0 vs. 451.2 U/ml, p <...
Monoclonal antibodies (mAbs) encoded by IGHV3-53 (VH3-53) targeting the spike receptor-binding domain (RBD) have been isolated from different COVID-19 patients. However, existence and prevalence of shared VH3-53-encoded in antibody repertoires is not clear. Using repertoire sequencing, we found that usage VH3-53 increased after SARS-CoV-2 infection. A highly VH3-53-J6 clonotype was identified 9 out 13 This derived convergent gene rearrangements with few somatic hypermutations evolutionary...
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named severe acute respiratory syndrome 2 (SARS-CoV-2), with some patients developing illness or even death. Disease severity has been associated increased levels of proinflammatory cytokines and lymphopenia. To elucidate the atlas peripheral immune response pathways that might lead to immunopathology during COVID-19 course, we performed blood RNA sequencing analysis same patient's samples collected from symptom onset full...
Abstract Despite timely immunization programs, and efficacious vaccines conveying protection against SARS-CoV-2 infection, breakthrough infections in vaccinated individuals have been reported. The Delta variant of concern (VOC) outbreak Guangzhou resulted local transmission non-vaccinated residents, providing a unique opportunity to study the protective effects inactivated infection. Here, we find that 2-dose group has similar peak viral titers comparable speeds RNA clearance but accelerated...
The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes lung and identify risk factors for impaired diffusion capacity.Non-critical COVID-19 patients admitted Guangzhou Eighth People's Hospital, China, were enrolled from March June 2020. Subjects prospectively followed up with tests at discharge, three six months after discharge.Eighty-six completed capacity timepoints. mean carbon...
ABSTRACT COVID-19, caused by SARS-CoV-2, is an acute self-resolving disease in most of the patients, but some patients can develop a severe illness or even death. To characterize host responses and identify potential biomarkers during progression, we performed longitudinal transcriptome analysis for peripheral blood mononuclear cells (PBMCs) collected from 4 COVID-19 at different time points symptom onset to recovery. We found that PBMCs stages exhibited unique characteristics. SARS-CoV-2...
Objective Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains pandemic with considerable morbidity and mortality around world. The aim of this study was to identify predictors for clinical deterioration in patients COVID-19 who did not show upon hospital admission.
Inflammation of epithelial and endothelial cells accelerates the progress acute lung injury (ALI), pulmonary fibrosis is leading cause mortality in patients with respiratory distress syndrome. Interleukin‑6 (IL‑6) a pleiotropic cytokine implicated pathogenesis number immune‑mediated disorders, involved fibrosis. Prohibitin (PHB) highly conserved protein various cellular functions, including proliferation, apoptosis, tumor suppression, transcription mitochondrial folding. PHB was identified...
As the coronavirus disease 19 (COVID-19) pandemic evolves, need for recognizing structural pulmonary changes of during early convalescence has emerged. Most studies focus on parenchymal destruction disease; but little is known about whether affects airway. This study was conducted to investigate in airway dimensions and explore associated factors patients with COVID-19.We retrospectively analyzed quantitative computed tomography (CT)-based measures 69 COVID-19 from 5 February 17 March 2020,...