A5108719279- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Contact Dermatitis and Allergies
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Occupational exposure and asthma
- Diabetes and associated disorders
- COVID-19 epidemiological studies
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Insects and Parasite Interactions
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Occupational and environmental lung diseases
Shanghai Jiao Tong University
2013-2025
Beijing Children’s Hospital
2025
Capital Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2014-2024
State Key Laboratory of Respiratory Disease
2015-2024
Guangzhou Medical University
2014-2024
Guangzhou University
2024
National Clinical Research
2020
Shanxi University
2020
Wuhan University
2015-2019
The emerging COVID-19 caused by SARS-CoV-2 infection poses severe challenges to global public health. Serum antibody testing is becoming one of the critical methods for diagnosis patients. We investigated IgM and IgG responses against nucleocapsid (N) spike (S) protein after symptom onset in intensive care unit (ICU) non-ICU 130 blood samples from 38 patients were collected. levels specific N S detected ELISA. A series collected along disease course same patient, including 11 ICU 27...
Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and link between specific interactions is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, Guangdong districts of Southern China,...
Abstract Background The inactivated Sinopharm/BBIBP COVID‐19 vaccine has been widely used in the world and joined COVAX supply program for developing countries. It is also well adapted usage low‐ middle‐income nations due to their low storage requirements. Objective This study aims report on kinetics, durability, neutralizing ability of induced immunity BBIBP vaccine, intensified antibody response elicited by booster. Methods A total 353 healthy adult participants, aged 20–74 years, were...
The diagnosis of coronavirus 19 (COVID-19) relies mainly upon viral nucleic acid detection, but false negatives can lead to missed and misdiagnosis; severe acute respiratory syndrome 2 (SARS-CoV-2)-specific antibody detection is convenient, safe highly sensitive. Immunoglobulin (Ig)M IgG are commonly used serologically diagnose COVID-19; however, the role IgA not well known. We aimed quantify levels SARS-CoV-2-specific IgM, antibodies, identify changes in them based on COVID-19 severity,...
The rapid emergence and global dissemination of the Omicron variant SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores urgent need for an enhanced understanding Omicron's pathophysiological mechanisms to guide clinical management shape health strategies. Our study is aimed at deciphering intricate molecular underlying infections, particularly focusing on identification specific biomarkers.
Grapevine downy mildew caused by Plasmopara viticola (Pv) is one of the most devastating diseases grapevine in China. To understand origin and pathogenicity Chinese Pv, a total 193 single-sporangiophore isolates were obtained from 14 major viticulture areas. Phylogenetic analyses suggest that Pv originate North America belong to P. clade aestivalis. Host range experiments reveal are able infect wide Vitis species different geographic origins, including Eurasian vinifera, American V....
ABSTRACT PRRs (Pattern‐Recognition Receptors) distributed on plant cell membranes recognize not only PAMPs (Pathogen‐Associated Molecular Patterns) released from the pathogens but also ligand peptides secreted plants, followed by eliciting defence responses. Here, we demonstrate that transcription of VvprePIP grape ( Vitis vinifera ) encoding precursor a PIP (PAMP‐Induced Peptide) peptide is activated Plasmopara viticola infection. Overexpression increases expression defence‐related genes...
Allergic diseases are increasing yearly. We aimed to evaluate the difference in allergen sensitization pattern between adults and children southern China by analyzing a large sample size of real-life data, provide evidence for formulating prevention management strategies. Retrospective analysis was conducted on 39,813 serum allergen-specific IgE (sIgE) results collected from January December 2017. Sensitization patterns how these allergens could lead allergic were analyzed respectively. The...
This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6) in patients with COVID-19, so as find a marker high sensitivity, specificity and easy detection evaluate lung injury inflammation COVID-19. Sixty-three COVID-19 43 non-COVID-19 similar phenotypes and/or imaging findings were enrolled test levels KL-6 using chemiluminescent immunoassay. In addition, blood gas, lymphocyte factors tests collected from all participants. The data was finally analyzed...
The distribution of allergens may vary with different geographic areas, suggesting the importance local epidemiological data to support evidence-based prevention and management allergic diseases. We investigated common in patients Guangzhou, southern China.7,047 symptoms were examined for serum sIgE 15 this region, based on protocol reversed enzyme allergosorbent test.4,869 (69.09%) subjects tested positive at least one allergens. There was no statistical difference overall rate detection...
Abstract Background Some patients with interstitial pneumonia autoimmune features (IPAF) showed a progressive course despite therapy. This study aimed to evaluate whether serial changes in the serum levels of surfactant protein-A (SP-A) and Krebs von den Lungen-6 (KL-6) can predict disease progression. Methods Sixty-four IPAF 41 non-fibrotic lung (non-FLD) were examined. Based on long-term function, 36 who followed up for more than 3 months divided into group ( n = 9), an improvement 13),...
Public health measures during COVID-19 have led to an unprecedented change in social lifestyle which might impact on the allergen sensitization population. We sought explore prevalence patterns of serum inhalant and food allergen-specific IgE (sIgE) total immunoglobulin E (tIgE) level among patients with clinical symptoms suspected allergic diseases before pandemic south China.A large epidemiology study was conducted sIgE tIgE 13,715 China from 2017 2020. Chi-square test Fisher exact were...
While serum periostin and Krebs von den Lungen-6 (KL-6) have been acknowledged as independent markers in idiopathic pulmonary fibrosis (IPF) diagnosis, the clinical combinatory potential of these biomarkers combined with high-resolution computed tomography (HRCT) has yet to be fully explored.
Few studies addressed trans-regional differences in allergen sensitization between areas within a similar latitudinal range but with distinct geomorphological features. We investigated specific IgE (sIgE) positivity to common allergens populations from two southern China provinces. Using uniformed protocol, serum samples were collected 2778 subjects suspected atopy coastal Guangdong and inland Yunnan. The overall prevalence of sIgE 57.8% (95% CI: 56.0%, 59.6%) vs 60.9% 59.1%, 62.7%) House...
Background Critically ill coronavirus disease 2019 (COVID-19) patients may suffer persistent systemic inflammation and multiple organ failure, leading to a poor prognosis. Research question To examine the relevance of novel inflammatory factor heparin-binding protein (HBP) in critically COVID-19 patients, evaluate correlation biomarker with progression. Study design methods 18 who suffered from respiratory failure sepsis, including 12 cases experienced rapidly deteriorating clinical...
Abstract Background Few studies have assessed the sensitization of mycotic allergens and Aspergillus fumigatus molecular allergens. This study aimed to investigate relationships A components in allergic bronchopulmonary aspergillosis (ABPA) patients (Af)‐sensitized asthma patients. Methods Serum sIgE levels Penicillium chrysogenum , Cladosporium herbarum Mucor racemosus Candida albicans Alternaria alternata Helminthosporium halodes, allergen (Asp f 1, Asp 2, 3, 4, 6) were measured via...