A5029548962- Vasculitis and related conditions
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Osteoarthritis Treatment and Mechanisms
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Ammonia Synthesis and Nitrogen Reduction
- Advanced Photocatalysis Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Adipose Tissue and Metabolism
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Selenium in Biological Systems
- Inflammatory mediators and NSAID effects
- Mercury impact and mitigation studies
- Gut microbiota and health
- Analytical chemistry methods development
- Dielectric materials and actuators
- Silicon and Solar Cell Technologies
- RNA modifications and cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Autophagy in Disease and Therapy
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2025
Jinan University
2021-2025
Nanjing University of Chinese Medicine
2025
First Affiliated Hospital Zhejiang University
2021-2024
Chengdu Sport University
2023-2024
Children's Hospital of Chongqing Medical University
2024
Shanghai Institute of Applied Physics
2024
State Key Laboratory of Respiratory Disease
2021-2024
Chongqing Medical University
2021-2024
First Affiliated Hospital of Guangzhou Medical University
2023-2024
Acute kidney injury (AKI) signifies a sudden and prolonged decline in function characterized by tubular cell death interstitial inflammation. Small nucleolar RNAs (snoRNAs) play pivotal roles oxidative stress inflammation, may an important role the AKI process, which remains elusive. elevated expression of Snord3a is revealed renal tubules response to demonstrates that deficiency alleviates mouse models. Notably, exhibits mitigating effect on stimulator interferon genes (STING)-associated...
Viral reactivation is widespread in patients with severe pneumonia, yet the landscape of viral lungs not well-known. This study aims to assess and clinical features early onset pneumonia ICU patients. The data from 97 were collected retrospectively intensive care units five teaching hospitals between June 2018 July 2021. Metagenomic next-generation sequencing (mNGS) bronchoalveolar lavage fluid (BALF) was performed at pneumonia. Cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1),...
Accurate forecast results of medium and long-term wind power quantity can provide an important basis for distribution plans, energy storage allocation plans generation after integration. However, there are still some problems such as low accuracy a degree integration physical processes. In this study, the Multi-step Informer network is proposed to add meteorological parameters make interpretable. The uses obtain initial training model according historical data generation, introduces speed...
The significance of detecting human herpesvirus 7 (HHV-7) in the lower respiratory tract patients with severe pneumonia is unclear. This study aims to evaluate clinical characteristics and prognosis HHV-7 pneumonia.Patients requiring invasive mechanical ventilation underwent commercial metagenomic next-generation sequencing (mNGS) testing bronchoalveolar lavage fluid from January 2019 March 2023 were enrolled 12 medical centers. Clinical data collected retrospectively, propensity score...
Monoclonal antibodies (mAbs) encoded by IGHV3-53 (VH3-53) targeting the spike receptor-binding domain (RBD) have been isolated from different COVID-19 patients. However, existence and prevalence of shared VH3-53-encoded in antibody repertoires is not clear. Using repertoire sequencing, we found that usage VH3-53 increased after SARS-CoV-2 infection. A highly VH3-53-J6 clonotype was identified 9 out 13 This derived convergent gene rearrangements with few somatic hypermutations evolutionary...
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named severe acute respiratory syndrome 2 (SARS-CoV-2), with some patients developing illness or even death. Disease severity has been associated increased levels of proinflammatory cytokines and lymphopenia. To elucidate the atlas peripheral immune response pathways that might lead to immunopathology during COVID-19 course, we performed blood RNA sequencing analysis same patient's samples collected from symptom onset full...
SARS-CoV-2 variants continue to emerge facing established herd immunity. L452R, previously featured in the Delta variant, quickly emerged Omicron subvariants, including BA.4/BA.5, implying a continued selection pressure on this residue. The underlying links between spike mutations and their selective pressures remain incompletely understood. Here, by analyzing 221 structurally characterized antibodies, we found that IGHV1-69-encoded antibodies preferentially contact L452 using...
Henoch-Schönlein purpura nephritis (HSPN) shares many similarities with IgA nephropathy. We aimed to analyze the predictive value of International Study Kidney Disease in Children (ISKDC) classification and updated Oxford for nephropathy HSPN patients.Data 275 patients (aged≥14 years) were retrieved, all them underwent a renal biopsy. re-classified biopsies according ISKDC their correlations clinical features outcomes. The endpoints defined as ≥30% reduction baseline estimated glomerular...
Gene panel selection aims to identify the most informative genomic biomarkers in label-free datasets. Traditional approaches, which rely on domain expertise, embedded machine learning models, or heuristic-based iterative optimization, often introduce biases and inefficiencies, potentially obscuring critical biological signals. To address these challenges, we present an gene strategy that harnesses ensemble knowledge from existing algorithms establish preliminary boundaries prior knowledge,...
Purpose (1) Exploring the evaluation and correlation of peripheral central auditory function in patients with chronic tinnitus. (2) Evaluation cumulative effect acupuncture on Method Our research is structured as a regulated randomized trial assessor blinding. Seventy-two participants who qualify tinnitus will be allocated 1:1 ratio to either group or sham group. Additionally, we recruit 15 healthy individuals subjects for data collection observe peripheral-central under different...