A5058673686- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- RNA modifications and cancer
- Cardiac pacing and defibrillation studies
- Ferroptosis and cancer prognosis
- Vascular anomalies and interventions
- Mechanisms of cancer metastasis
- Cancer-related molecular mechanisms research
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- Cancer Cells and Metastasis
- Cardiovascular and Diving-Related Complications
- Cancer Genomics and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Shanghai Sixth People's Hospital
2018-2024
Shanghai First Maternity and Infant Hospital
2022-2024
Oregon State University
2024
Xinjiang Institute of Ecology and Geography
2024
Chinese Academy of Sciences
2024
Wuxi Fourth People's Hospital
2023-2024
Jiangnan University
2023-2024
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A colorectal cancer (CRC) very limited. We designed this study to investigate role CRC. Methods Expression level METTL14 was extracted from public database and tissue array clinical relevance Next, gain/loss function experiment used define progression Moreover, transcriptomic sequencing (RNA-seq) applied screen potential targets METTL14. The specific...
Purpose.: Myopia is an important cause of correctable visual impairment worldwide. Genetic and environmental factors contribute to its development. The population Chinese university students consists approximately 30 million young people characterized by academic excellence similar ages. To date, little known about their refractive status. Our study designed investigate the prevalence myopia in this specific population. Methods.: This a cross-sectional among Shanghai, China; 5083 from...
Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution chemokines tumor microenvironment to metastasis not fully understood.Herein, we examinined several patients using chemokine ELISA array. Immunohistochemistry was used detect expression CXCL5 tissues. Human HCT116 and SW480 cell lines stably transfected with CXCL5, shCXCL5 shCXCR2 lentivirus plasmids were our vitro study. Immunoblot, immunofluorescence transwell assay examine molecular biology...
Background The standard neoadjuvant treatments in patients with esophageal squamous cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed China. Methods This was an open-label, single-arm, phase 2 trial. Patients potentially resectable ESCC (cT1b-3, Nany, M0 T4a, N0-1, M0) received preoperative intravenous sintilimab plus triplet chemotherapy (liposomal paclitaxel, cisplatin, and S-1) every 3 weeks for two cycles. primary endpoints were surgical...
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially metastasis. However, the related mechanism not fully discovered yet. Herein we demonstrated that novel of cell migration and invasion, caveolin-1, direct interaction with NDRG1 human colorectal cancer (CRC) cells. Moreover, reduces caveolin-1 protein expression through promoting its ubiquitylation subsequent degradation via proteasome CRC...
Abstract Nuclear localization of PTEN is essential for its tumor suppressive role, and loss nuclear more prominent than cytoplasmic in many kinds cancers. However, PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that unstable PTEN, here we identify F-box only protein 22 (FBXO22) induces ubiquitylation but not at lysine 221, which responsible degradation PTEN. FBXO22 plays a tumor-promoting role by ubiquitylating degrading In accordance, overexpressed various...
Colorectal cancer (CRC) is one of the most common malignant tumors in world. Ferroptosis a newly defined form cell death, distinguished by different morphology, biochemistry, and genetics, involved CRC progression treatment. This study aims to establish predictive model elucidate relationship between ferroptosis prognosis patients, explore potential value therapeutic options.The ferroptosis-related genes were obtained from GeneCards FerrDb websites. The limma R package was used screen...
The integrative multiomics characterization of minute amounts clinical tissue specimens has become increasingly important. Here, we present an approach called Integral-Omics, which enables sequential extraction metabolites, lipids, genomic DNA, total RNA, proteins, and phosphopeptides from a single biopsy-level specimen. We benchmarked this method with various samples, applied the workflow to perform profiling tissues six patients colorectal cancer, found that tumor exhibited suppressed...
The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated chelators and can inhibit cancer cell migration. However, the mechanism of how NDRG1 achieves this effect remains unclear. In study, we implemented established newly constructed overexpression knockdown models using DU145, HT29, HCT116 lines to investigate molecular basis which exerts its inhibitory on Using these models, demonstrated that inhibits...
NANOG is a key transcription factor that overexpressed and plays an important role in various cancers. Its overexpression associated with highly tumorigenic, drug-resistant, poor prognosis. However, the underlying mechanism of action ovarian cancer remains unclear. Epithelial-mesenchymal transition (EMT), which critical process invasion metastasis, also drug resistance. We determined whether EMT chemoresistance epithelial cells. expression was increased cells (HEY SKOV3) compared normal...
Total anomalous pulmonary venous connection (TAPVC) is recognized as a rare congenital heart defect (CHD). With high mortality rate of approximately 80%, the survival and outcomes TAPVC patients are not satisfactory. However, genetic aetiology mechanism remain elusive. This study aimed to investigate underlying genomic risks through next-generation sequencing (NGS).Rare variants were identified whole exome (WES) 78 sporadic cases 100 healthy controls using Fisher's exact test gene-based...
Abstract The human coronavirus HCoV-19 infection can cause acute respiratory distress syndrome (ARDS), hypercoagulability, hypertension, extrapulmonary multiorgan dysfunction. Effective antiviral and anti-coagulation agents with safe clinical profiles are urgently needed to improve the overall prognosis. We screened an FDA approved drug library found that anticoagulant agent dipyridamole (DIP) suppressed replication at EC50 of 100 nM in vitro . It also elicited potent type I interferon...
Intake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing PUFA often considered beneficial. However, the role n-6/n-3 in regulation metabolism has been much debated. Therefore, this study was performed on effect different proportions diet quality life patients with hyperlipidemia, aiming to explore appropriate provide theoretical basis development application nutritional blended oil future.These 75 participants were...