Karen James

ORCID: 0000-0002-9558-7486
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About
Contact & Profiles
Research Areas
  • Mechanical Circulatory Support Devices
  • Cardiac Structural Anomalies and Repair
  • Cardiovascular Function and Risk Factors
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Transplantation: Methods and Outcomes
  • Heart Failure Treatment and Management
  • Viral Infections and Immunology Research
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Acute Myocardial Infarction Research
  • Cardiac pacing and defibrillation studies
  • Pulmonary Hypertension Research and Treatments
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Valve Diseases and Treatments
  • Fuel Cells and Related Materials
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Diabetes Management and Research
  • Renal Transplantation Outcomes and Treatments
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Clinical Laboratory Practices and Quality Control
  • Cardiomyopathy and Myosin Studies
  • Cardiovascular Effects of Exercise
  • Venous Thromboembolism Diagnosis and Management
  • COVID-19 and healthcare impacts

Cleveland Clinic
2000-2023

Medical University of Silesia
2017-2022

Laboratoire Informatique d'Avignon
2022

Silesian Center for Heart Disease
2022

Liverpool Heart and Chest Hospital
2022

University of Liverpool
2022

Manchester University NHS Foundation Trust
2021

Wirral University Teaching Hospital NHS Foundation Trust
2021

University of Manchester
2021

Wythenshawe Hospital
2021

BACKGROUND The uptake of F-18 deoxyglucose into dysfunction segments after myocardial infarction identifies metabolically active (FDG+) or inactive (FDG-) myocardium. Although patients with FDG+ have been found to be at risk for adverse events, the prognostic significance viable myocardium in relation other influences on postinfarction prognosis, including revascularization, remain ill defined. purpose this study was investigate relative tissue and establish whether revascularization...

10.1161/01.cir.90.6.2687 article EN Circulation 1994-12-01

Abstract High-resolution ultrasonography was used to classify carotid plaques into five different types in 72 patients with symptoms and 49 without, stenosis of the origin internal artery < 70 per cent. There were symptomatic group 75 asymptomatic group. Type 1 uniformly echolucent, type 2 predominantly 3 echogenic, 4 echogenic 5 consisted that could not be classified owing heavy calcification acoustic shadows. Plaque found 90 cent 10 those plaque 53 47 cent, 34 66 95 respectively....

10.1002/bjs.1800801016 article EN British journal of surgery 1993-10-01

Background The HeartMate left ventricular assist device has been successfully used as a bridge to cardiac transplantation. Because many patients exhibit marked clinical improvement in their heart failure after implantation, we studied the physiological effect of this on neurohormonal axis. Methods and Results In 13 awaiting transplant (mean index, 1.7±0.3 L · min −1 m −2 ) who underwent venous atrial natriuretic peptide, epinephrine, norepinephrine, plasma renin activity, angiotensin,...

10.1161/01.cir.92.9.191 article EN Circulation 1995-11-01

Abstract Background Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to technique. Newer technologies such as magnetic seeds may allow some these challenges be overcome. The aim was compare safety and effectiveness wire seed techniques. Methods Women undergoing standard or lesions between August 2018 2020 were recruited prospectively this IDEAL stage 2a/2b platform cohort study. primary outcome defined...

10.1093/bjs/znab443 article EN cc-by British journal of surgery 2021-12-09

Congestive heart failure is associated with blood volume expansion caused by stimulation of the renin-aldosterone system and arginine vasopressin. The use left ventricular assist devices as bridges to transplantation has improved survival patients during this critical period. In studying physiology on support devices, we hypothesized that improvement cardiac function a device normalization load secondary its regulatory substances.We studied 15 (13 men, 2 women: age 51 +/- 8 years) end-stage...

10.1161/01.cir.93.8.1515 article EN Circulation 1996-04-15

Acute cardiac rejection involves myocyte necrosis. Hence, markers of death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I T were measured 186 patients undergoing 365 endomyocardial biopsies. No differences noted with (rejectors vs. nonrejectors: CK=63.8 U/L 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml 2.06 ng/ml, P=0.949; troponin T=0.134 0.0881 P=0.374; I=0.216 0.707 P=0.357). The time course levels rejectors nonrejectors do not differ both groups having...

10.1097/00007890-199612270-00046 article EN Transplantation 1996-12-01

This article describes a process for linking job analysis data to test specifications. Rasch rating scale is used order the ratings of importance assigned task and content items by practicing laboratory managers. ordering produces variables representing range from most least important. The also provide an objective frame reference review experts. calibrations each item are transformed percentages based on useful limits. From percentages, specifications reflecting practice patterns in field...

10.1177/016327878901200205 article EN Evaluation & the Health Professions 1989-06-01
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