Milind Y. Desai
A5032516793- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Acute Myocardial Infarction Research
- Pericarditis and Cardiac Tamponade
- Takotsubo Cardiomyopathy and Associated Phenomena
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Rate Variability and Autonomic Control
Cleveland Clinic
2016-2025
Center for Clinical Research (United States)
2022-2025
Orthopedic Institute
2020-2025
Dartmouth College
2024
Gates (United States)
2024
Cleveland Clinic Florida
2024
Case Western Reserve University
2008-2023
Cleveland Clinic Lerner College of Medicine
2018-2023
Northwestern University
1983-2023
University of Pennsylvania
2023
Coronary artery inflammation inhibits adipogenesis in adjacent perivascular fat. A novel imaging biomarker-the fat attenuation index (FAI)-captures coronary by mapping spatial changes of on computed tomography angiography (CTA). However, the ability FAI to predict clinical outcomes is unknown.In Cardiovascular RISk Prediction using Computed Tomography (CRISP-CT) study, we did a post-hoc analysis outcome data gathered prospectively from two independent cohorts consecutive patients undergoing...
Statins reduce low-density lipoprotein cholesterol (LDL-C) levels and slow progression of coronary atherosclerosis. However, no data exist describing the relationship between statin-induced changes in high-density (HDL-C) disease progression.To investigate LDL-C HDL-C atheroma burden.Post-hoc analysis combining raw from 4 prospective randomized trials (performed United States, North America, Europe, Australia 1999 2005), which 1455 patients with angiographic underwent serial intravascular...
Fast and reliable detection of patients with severe heterogeneous illnesses is a major goal precision medicine1,2. Patients leukaemia can be identified using machine learning on the basis their blood transcriptomes3. However, there an increasing divide between what technically possible allowed, because privacy legislation4,5. Here, to facilitate integration any medical data from owner worldwide without violating laws, we introduce Swarm Learning-a decentralized machine-learning approach that...
Coronary inflammation induces dynamic changes in the balance between water and lipid content perivascular adipose tissue (PVAT), as captured by Fat Attenuation Index (FAI) standard coronary CT angiography (CCTA). However, is not only process involved atherogenesis we hypothesized that additional radiomic signatures of adverse fibrotic microvascular PVAT remodelling, may further improve cardiac risk prediction.
<h3>Importance</h3> There is limited evidence regarding early treatment of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to mitigate symptom progression. <h3>Objective</h3> To examine whether high-dose zinc and/or ascorbic acid reduce the severity or duration symptoms compared with usual care among ambulatory patients SARS-CoV-2 infection. <h3>Design, Setting, and Participants</h3> This multicenter, single health system randomized clinical factorial open-label...
Purpose Athletes and members of the public increasingly rely on wearable HR monitors to guide physical activity training. The accuracy newer, optically based is unconfirmed. We sought assess five during various types aerobic exercise. Methods Fifty healthy adult volunteers (mean ± SD age = 38 12 yr, 54% female) completed exercise protocols a treadmill, stationary bicycle, an elliptical trainer (±arm movement). Each participant underwent monitoring with electrocardiogaphic chest strap monitor...
Septal reduction therapy (SRT), surgical myectomy or alcohol ablation, is recommended for obstructive hypertrophic cardiomyopathy (oHCM) patients with intractable symptoms despite maximal medical therapy, but associated morbidity and mortality. This study sought to determine whether the oral myosin inhibitor mavacamten enables improve sufficiently no longer meet guideline criteria choose not undergo SRT. Patients left ventricular (LV) outflow tract (LVOT) gradient ≥50 mm Hg at...
Background— In patients with hypertrophic cardiomyopathy and left ventricular outflow tract (LVOT) obstruction, but without basal septal hypertrophy, we sought to identify mitral valve (MV) papillary muscle (PM) abnormalities that predisposed LVOT using echo cardiac magnetic resonance. Methods Results— We studied 121 (age, 49±17 years; 60% men; 57% on β-blockers) a thickness of ≤1.8 cm who underwent echocardiography (rest+stress) cine Echo measurements included maximal gradient...