Thomas Ulas
A5007372940- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Bioinformatics and Genomic Networks
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Blood disorders and treatments
- Immunotherapy and Immune Responses
- Digestive system and related health
- Gene expression and cancer classification
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Sepsis Diagnosis and Treatment
German Center for Neurodegenerative Diseases
2018-2025
University of Bonn
2016-2025
Epigenomics (Germany)
2019-2025
Life & Brain (Germany)
2015-2021
Technische Universität Braunschweig
2012-2021
Genomics (United Kingdom)
2021
Charité - Universitätsmedizin Berlin
2021
Highlights•Macrophages react with specific transcriptional programming upon distinct signals•Activation by TNF, PGE2, and P3C activates a STAT4-associated program•NFKB1, JUNB, CREB1 are central transcription factors of macrophage activation•Inflammatory signatures lost in alveolar macrophages from COPD patientsSummaryMacrophage activation is associated profound reprogramming. Although much progress has been made the understanding activation, polarization, function, programs regulating these...
Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential decipher how microglial properties temporally regulated by intrinsic extrinsic factors, such as sexual identity the microbiome. Here, we found microglia undergo differentiation phases, discernable transcriptomic signatures chromatin accessibility landscapes, which can diverge in adult males females. Remarkably, absence of microbiome germ-free mice had a time...
Fast and reliable detection of patients with severe heterogeneous illnesses is a major goal precision medicine1,2. Patients leukaemia can be identified using machine learning on the basis their blood transcriptomes3. However, there an increasing divide between what technically possible allowed, because privacy legislation4,5. Here, to facilitate integration any medical data from owner worldwide without violating laws, we introduce Swarm Learning-a decentralized machine-learning approach that...
How dying tumor cells get noticed Besides killing directly, some chemotherapies, such as anthracyclines, also activate the immune system to kill tumors. Vacchelli et al. discovered that in mice, anthracycline-induced antitumor immunity requires express protein formyl peptide receptor 1 (FPR1). Dendritic (DCs) near tumors expressed especially high amounts of FPR1. DCs normally capture fragments and use them nearby T tumors, but lacking FPR1 failed do this effectively. Individuals with breast...
The cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.
Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white (WM) multiple sclerosis (MS) non-neurological control donors, to find possible early changes related MS pathology. Microglia show a clear region-specific profile, indicated by higher expression type-I interferon genes in GM NF-κB pathway WM. Transcriptional microglia also differ between WM increased lipid metabolism gene expression, which relates pathology since active...
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
Wound healing is a coordinated process that initially relies on pro-inflammatory macrophages, followed by pro-resolution function of these cells. Changes in cellular metabolism likely dictate distinct activities, but the nature changes has been unclear. Here, we profiled early- versus late-stage skin wound macrophages mice at both transcriptional and functional levels. We found glycolytic early phase not sufficient to ensure productive repair. Instead, combining conditional disruption...
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, heterogeneity remains largely unknown, hampering clinical use. High-dimensional techniques were elucidate transcriptional, phenotypic, functional differences between human vivo mononuclear phagocytes facilitate full potential the clinic. We demonstrate that monocytes...
In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of DCs (cDC1 cDC2 DCs) one class (pDCs) have been shown be transcriptionally functionally distinct entities. humans, these three DC subtypes can identified using the cell surface markers CD1c (cDC2), CD141 (cDC1), CD303 (pDCs), albeit it remains elusive whether functionality is mainly determined by ontogeny or tissue...
Abstract Background The interplay of epigenetic processes and the intestinal microbiota may play an important role in development homeostasis. Previous studies have established that regulates a large proportion epithelial transcriptome adult host, but microbial effects on DNA methylation gene expression during early postnatal are still poorly understood. Here, we sought to investigate cells (IECs) development. Methods We collected IECs from small intestine each five 1-, 4- 12 16-week-old...