A5077178350- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- COVID-19 and Mental Health
- Antibiotic Use and Resistance
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- Enterobacteriaceae and Cronobacter Research
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- Nosocomial Infections in ICU
- Tracheal and airway disorders
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Biosensors and Analytical Detection
- Vibrio bacteria research studies
- Vaccine Coverage and Hesitancy
- Infection Control in Healthcare
- Kawasaki Disease and Coronary Complications
- Orthopedic Infections and Treatments
Kantonsspital St. Gallen
2018-2025
University of St. Gallen
2016-2025
University of Zurich
2015-2024
Kantonsspital Graubünden
2022-2024
Oregon Medical Research Center
2023
Advisory Board Company (United States)
2023
University Hospital of Basel
2015-2023
Communities In Schools of Orange County
2023
Manhattan Institute for Policy Research
2023
University of Pittsburgh
2023
Production of TNF-alpha and IL-1 in infectious autoimmune diseases is associated with fever, fatigue, sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm thereby locomotor activity may alter architecture we assessed influence on timing system. shown here suppress expression PAR bZip clock-controlled Dbp, Tef, Hlf period Per1, Per2, Per3 fibroblasts vitro vivo...
Invasive Mycobacterium chimaera infections were diagnosed in 2012 2 heart surgery patients on extracorporeal circulation. We launched an outbreak investigation to identify the source and extent of potential implement preventive measures.We collected water samples from operating theaters, intensive care units, wards, including air theaters. strains characterized by randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Case detection was performed based archived...
In 2014, the Joint United Nations Programme on HIV and AIDS (UNAIDS) partners set '90-90-90 targets'; aiming to diagnose 90% of all positive people, provide antiretroviral therapy (ART) for those diagnosed achieve viral suppression treated, by 2020. This results in 81% people treatment 73% achieving suppression. We aimed analyse how effective national programmes are at meeting these targets, using care continuums or cascades.We searched cascades 196 countries published papers, conference...
We identified 10 patients with disseminated Mycobacterium chimaera infections subsequent to open-heart surgery at three European Hospitals. Infections originated from the heater–cooler unit of heart–lung machine. Here we describe clinical aspects and treatment course this novel entity. Interdisciplinary care follow-up all was documented by study team. Patients' characteristics, manifestations, microbiological findings, therapeutic measures including surgical reinterventions were reviewed...
Antibiotic overuse drives antibiotic resistance. Gram-negative bacteremia is a common infection that results in substantial use.To compare the clinical effectiveness of C-reactive protein (CRP)-guided, 7-day, and 14-day durations 30, 60, 90 days after treatment initiation.Multicenter, noninferiority, point-of-care randomized trial including adults hospitalized with gram-negative conducted 3 Swiss tertiary care hospitals between April 2017 May 2019, follow-up until August 2019. Patients...
Disentangling the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and vaccination on occurrence post-acute sequelae SARS-CoV-2 (PASC) is crucial to estimate reduce burden PASC.We performed a cross-sectional analysis (May/June 2022) within prospective multicenter healthcare worker (HCW) cohort in north-eastern Switzerland. HCWs were stratified by viral variant status at time their first positive nasopharyngeal swab. without swab with negative serology served...
Abstract Heater–cooler units (HCUs) were recently identified as a source of Mycobacterium chimaera causing surgical site infections. We investigated transmission this bacterium from HCUs to the field by using thermic anemometer and particle counter, videotape an operating room equipped with ultraclean laminar airflow ventilation system, bacterial culture sedimentation plates in nonventilated room. Smoke HCU reached 23 s merging air. The produced on average 5.2, 139, 14.8 particles/min at...
Cystic fibrosis (CF) is a life-threatening genetic disorder, characterized by chronic microbial lung infections due to abnormally viscous mucus secretions within airways. The clinical management of CF typically involves regular respiratory-tract cultures in order identify pathogens and guide treatment. However, culture-based methods can miss atypical or slow-growing microbes. Furthermore, the isolated microbes are often not classified at strain level limited taxonomic resolution.Here, we...
Abstract Objectives Seroprevalence studies to assess the spread of SARS-CoV-2 infection in general population and subgroups are key for evaluating mitigation vaccination policies understanding disease both on national level comparison with international community. Methods Corona Immunitas is a research program coordinated, population-based, seroprevalence implemented by Swiss School Public Health (SSPH+). Over 28,340 participants, randomly selected age-stratified, some regional specificities...
Abstract Background Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there are little data on possible immunoglobulin (Ig) A–mediated responses. Here, we aim determine whether COVID-19 is associated with a vigorous total IgA response and antibodies of severe illness. Since thrombotic events frequent in resemble hypercoagulation antiphospholipid syndrome, our approach focused (aPL). Methods In this...
To describe the HIV care cascade for Switzerland in year 2012.Six levels were defined: (i) HIV-infected, (ii) HIV-diagnosed, (iii) linked to care, (iv) retained (v) on antiretroviral treatment (ART), and (vi) with suppressed viral load. We used data from Swiss Cohort Study (SHCS) complemented by a nationwide survey among SHCS physicians estimate number of HIV-patients not registered cohort. also ART sales patients treated outside network. Based we inferred estimates previously published...
This study was carried out to detect differences in locomotion and feeding behavior lame (group L; n = 41; gait score ≥ 2.5) non-lame C; 12; ≤ 2) multiparous Holstein cows a cross-sectional design. A model for automatic lameness detection created, using data from accelerometers attached the hind limbs noseband sensors head. Each cow's videotaped scored on 5-point scale before after period of 3 consecutive days behavioral recording. The mean value independent experienced observers taken as...
Invasive Mycobacterium chimaera infections after open-heart surgery have been reported internationally. These devastating result from aerosols generated by contaminated heater-cooler units used with extracorporeal circulation during surgery. Despite intensified cleaning and disinfection, surveillance samples factory-new acquired 2014 grew nontuberculous mycobacteria a median of 174 days.
Abstract Objectives The sensitivity of molecular and serological methods for COVID-19 testing in an epidemiological setting is not well described. aim the study was to determine frequency negative RT-PCR results at first clinical presentation as after a follow-up least 3 weeks. Methods Among all patients seen suspected Liechtenstein (n=1921), we included initially positive index (n=85) (n=66) with SARS-CoV-2 antibody testing. Antibodies were detected seven different commercially available...
Protecting healthcare workers (HCWs) from coronavirus disease-19 (COVID-19) is critical to preserve the functioning of systems. We therefore assessed seroprevalence and identified risk factors for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) seropositivity in this population.Between 22 June 15 August 2020, HCWs institutions northern/eastern Switzerland were screened SARS-CoV-2 antibodies. recorded baseline characteristics, non-occupational occupational factors. used pairwise...
Pan-immunoglobulin assays can simultaneously detect IgG, IgM and IgA directed against the receptor binding domain (RBD) of S1 subunit spike protein (S) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 S1-RBD Ig). In this work, we aim to evaluate a quantitative SARS-CoV-2 Ig electrochemiluminescence immunoassay (ECLIA) regarding analytical, diagnostic, operational clinical characteristics. Our work takes form population-based study in principality Liechtenstein, including 125 cases...
Abstract Background The burden of long-term symptoms (ie, long COVID) in patients after mild COVID-19 is debated. Within a cohort healthcare workers (HCWs), frequency and risk factors for compatible with COVID are assessed. Methods Participants answered baseline (August/September 2020) weekly questionnaires on SARS-CoV-2 nasopharyngeal swab (NPS) results acute disease symptoms. In January 2021, serology was performed; March, (including psychometric scores) were asked compared between HCWs...
Knowledge about protection conferred by previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and/or vaccination against emerging viral variants allows clinicians, epidemiologists, and health authorities to predict reduce the future Disease 2019 (COVID-19) burden. We investigated risk symptoms of SARS-CoV-2 (re)infection vaccine breakthrough during Delta Omicron waves, depending on baseline immune status subsequent vaccinations.In this prospective, multicentre...