A5020659721- Antibiotic Use and Resistance
- Surgical site infection prevention
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Infection Control in Healthcare
- Respiratory viral infections research
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotic Resistance in Bacteria
- Infection Control and Ventilation
- Bacterial Identification and Susceptibility Testing
- Orthopedic Infections and Treatments
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Medical Device Sterilization and Disinfection
- Cytomegalovirus and herpesvirus research
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Infections and bacterial resistance
- Antimicrobial Resistance in Staphylococcus
- Influenza Virus Research Studies
- Urinary Tract Infections Management
University Hospital of Bern
2016-2024
University of Bern
2016-2024
University of Lucerne
2021-2024
Oregon Medical Research Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
New York Proton Center
2024
Lindsay Unified School District
2024
University of Geneva
2009-2023
University of Zurich
2015-2023
Invasive Mycobacterium chimaera infections were diagnosed in 2012 2 heart surgery patients on extracorporeal circulation. We launched an outbreak investigation to identify the source and extent of potential implement preventive measures.We collected water samples from operating theaters, intensive care units, wards, including air theaters. strains characterized by randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Case detection was performed based archived...
We identified 10 patients with disseminated Mycobacterium chimaera infections subsequent to open-heart surgery at three European Hospitals. Infections originated from the heater–cooler unit of heart–lung machine. Here we describe clinical aspects and treatment course this novel entity. Interdisciplinary care follow-up all was documented by study team. Patients' characteristics, manifestations, microbiological findings, therapeutic measures including surgical reinterventions were reviewed...
With the ongoing COVID-19 pandemic, it is crucial to assess current burden of disease community-acquired SARS-CoV-2 Omicron variant in hospitalized patients tailor appropriate public health policies. Comparisons with better-known seasonal influenza infections may facilitate such decisions.To compare in-hospital outcomes influenza.This cohort study was based on a national and registry. Hospitalized aged 18 years older infection who were admitted between January 15 March 15, 2022 (when...
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent unifying characteristic of both natural infection all candidates tested date. To investigate the mechanisms underlying arenavirus nAb evasion we engineered several envelope-chimeric viruses glycan-deficient variants thereof. We performed neutralization tests with sera from experimentally infected...
Abstract Heater–cooler units (HCUs) were recently identified as a source of Mycobacterium chimaera causing surgical site infections. We investigated transmission this bacterium from HCUs to the field by using thermic anemometer and particle counter, videotape an operating room equipped with ultraclean laminar airflow ventilation system, bacterial culture sedimentation plates in nonventilated room. Smoke HCU reached 23 s merging air. The produced on average 5.2, 139, 14.8 particles/min at...
There has been some concern that leucotriene receptor antagonists might precipitate the onset of Churg-Strauss syndrome (CSS). A study was undertaken to investigate relationship between antagonist montelukast and CSS.Medication histories 78 patients with CSS from France Germany were retraced by questioning patients, treating physicians dispensing pharmacists, medical records. Using a case-crossover research design, exposures other asthma medications during 3-month "index" period immediately...
Interferon-driven inflammation in chronic viral infection blocks generation of sustained B cell responses. See related Research Articles by Moseman et al. and Sammicheli a Focus Laidlaw
Importance Preoperative skin antisepsis is an established procedure to prevent surgical site infections (SSIs). The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated. Objective To determine whether in alcohol noninferior gluconate SSIs after cardiac abdominal surgery. Design, Setting, and Participants Multicenter, cluster-randomized, investigator-masked, crossover, noninferiority trial; 4403 patients undergoing surgery 3 tertiary care hospitals...
For vaccines, CD4 + T cells can spell trouble The ideal vaccine elicits immune memory—either antibodies or memory cells—to protect the host from subsequent infections. cell–mediated immunity requires both helper and cytotoxic CD8 to kill virus-infected cells. But what happens when a only cells? Penaloza-MacMaster et al. probed this question by giving mice that generated against lymphocytic choriomeningitis virus (LCMV). Instead of protecting chronic LCMV, vaccinated developed massive...
Invasive Mycobacterium chimaera infections after open-heart surgery have been reported internationally. These devastating result from aerosols generated by contaminated heater-cooler units used with extracorporeal circulation during surgery. Despite intensified cleaning and disinfection, surveillance samples factory-new acquired 2014 grew nontuberculous mycobacteria a median of 174 days.
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to lymphocytic choriomeningitis (LCMV), a prototypic mouse model systemic infection. Mice expressing transgenic B cell receptors LCMV-unrelated specificity, and mice unable produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed...
Investigations of a worldwide epidemic invasive Mycobacterium chimaera associated with heater-cooler devices in cardiac surgery have been hampered by low clinical awareness and challenging diagnoses.Using data from Switzerland, we estimated the burden M. to be 156-282 cases/year 10 major valve replacement market countries.
BACKGROUNDThe overall burden of healthcare-associated infections (HAIs) remains high, even in high-income countries. However, the current HAI Switzerland is unknown. Prevalence surveys have a long tradition field infection prevention and control for measuring both antimicrobial use. The objective this survey was to test point prevalence (PPS) methodology European Centre Disease Prevention Control (ECDC) acute-care hospitals Switzerland.
BACKGROUND As clinical signs of COVID-19 differ widely among individuals, from mild to severe, the definition risk groups has important consequences for recommendations public, control measures and patient management, needs be reviewed regularly. AIM The aim this study was explore factors in-hospital mortality intensive care unit (ICU) admission hospitalised patients during first epidemic wave in Switzerland, as an example a country that coped well pandemic. METHODS This included all (n =...
Clostridioides difficile causes nosocomial outbreaks which can lead to severe and even life-threatening colitis. Rapid molecular diagnostic tests allow the identification of toxin-producing, potentially hypervirulent strains, is critical for patient management infection control. PCR-ribotyping has been used decades as reference standard investigate transmission in suspected outbreaks. However, introduction whole genome sequencing (WGS) epidemiology provides a realistic alternative...
Importance World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited. Objective To assess whether earlier vs later timing of administration cefuroxime SAP associated with the occurrence site infections (SSI). Design, Setting, and Participants This cohort study included adult patients who underwent 1 11 major...
A large clonal outbreak caused by vancomycin-resistant Enterococcus faecium (VRE) affected the Bern University Hospital group from end of December 2017 until July 2020. We describe characteristics and bundle infection prevention control (IPC) measures implemented. The was first recognised when two concomitant cases VRE bloodstream were identified on oncology ward. During 32 months, 518 patients in 1,300-bed hospital as vanB carriers. Eighteen (3.5%) developed an invasive infection, whom...
Background Since the onset of COVID-19 pandemic, disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data. Aim This study compares in-hospital outcomes for patients community-acquired and influenza in Switzerland. Methods retrospective multi-centre cohort includes > 18 years admitted or A/B infection determined by RT-PCR. Primary secondary were mortality intensive care unit (ICU) admission influenza. We used Cox regression...
We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I medical device. Triggered by increase in cepacia complex (BCC) bacteremias and the detection BCC unopened packages ad hoc national committee comprising representatives public health organisation, regulatory agency, expert association convened commissioned investigation. The investigation included retrospective case finding across Switzerland whole genome sequencing...