A5009362952- Antibiotic Use and Resistance
- Health Systems, Economic Evaluations, Quality of Life
- Clostridium difficile and Clostridium perfringens research
- Meta-analysis and systematic reviews
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Statistical Methods in Clinical Trials
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Ethics in Clinical Research
- Urinary Tract Infections Management
- Surgical site infection prevention
- Microscopic Colitis
- COVID-19 and Mental Health
- Antibiotic Resistance in Bacteria
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Infection Control in Healthcare
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Clinical practice guidelines implementation
Hamilton Health Sciences
2016-2025
McMaster University
2016-2025
Impact
2017-2025
Population Health Research Institute
2023-2025
Juravinski Hospital
2014-2024
University Hospital of Zurich
2024
Office of Infectious Diseases
2024
Museum of Heilongjiang Province
2021
Health Sciences Centre
2015-2021
Cochrane
2021
Lack of appropriate reporting methodological details has previously been shown to distort risk bias assessments in randomized controlled trials. The same might be true for observational studies. goal this study was compare the Newcastle-Ottawa Scale (NOS) assessment between reviewers and authors cohort studies included a published systematic review on factors severe outcomes patients infected with influenza. Cohort 2008–2011 were included. corresponding or first completed survey covering all...
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
The WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries hospitals in promoting rational use of antibiotics while improving access these essential medicines. We aimed describe patterns worldwide antibiotic according the AWaRe adult inpatient population.The Global Point Prevalence Survey on Antimicrobial Consumption Resistance (Global-PPS) collects hospital data using a standardized PPS methodology. Global-PPS 2015, 2017 2018 data, collected by 664 69...
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge antimicrobial resistance, antibiotics were reviewed and categorized into three groups: Access, Watch Reserve, leading a new categorization called AWaRe. These categories developed taking account impact different classes implications for their 2023 AWaRe...
The anterior nares are the most important screening site of colonization with Staphylococcus aureus. We screened 2966 individuals for S. aureus carriage swabs both and throat. A total 37.1% persons were nasal carriers, 12.8% solely throat carriers. Screening significantly increases sensitivity detection among carriers by 25.7%.
To evaluate outcomes following implementation of a checklist with criteria for switching from intravenous (iv) to oral antibiotics on unselected patients two general medical wards.During 12 month intervention study, printed the third day iv treatment was placed in charts. The decision switch left discretion attending physician. Outcome parameters 4 control phase before were compared equivalent period during seasonal confounding (before-after study; April July 2006 and 2007, respectively):...
Background: Approximately 25% of Staphylococcus aureus carriers have exclusive throat carriage.We aimed to identify the populations at risk for carriage improve sensitivity detect carriers.Methods: Four groups underwent nasal and screening S aureus.Three individuals in community (n = 2632) with different estimated levels exposure health care system (HCS) were screened, including 1500 healthy blood donors, 498 patients from a school dental medicine, 634 workers (HCWs) trade fair.The fourth...
Abstract The coronavirus disease 2019 (COVID-19) pandemic and antimicrobial resistance (AMR) are parallel interacting health emergencies that provide the opportunity for mutual learning. As their measures consequences comparable, COVID-19 helps to illustrate potential long-term impact of AMR, which is less acute but not crucial. They may also each other as there a push use existing antimicrobials treat critically ill patients in absence specific treatments. Attempts manage spread lead...
To investigate the planning of subgroup analyses in protocols randomised controlled trials and agreement with corresponding full journal publications.Cohort trial subsequent publications.Six research ethics committees Switzerland, Germany, Canada.894 involving patients approved by participating between 2000 2003 515 publications.Of 894 trials, 252 (28.2%) included one or more planned analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least analysis, 10 (4.0%) anticipated...
Background: It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. Objective: To determine whether are noninferior to respirators prevent in health care workers providing routine care. Design: Multicenter, randomized, noninferiority trial. (ClinicalTrials.gov: NCT04296643). Setting: 29 facilities Canada, Israel, Pakistan, and Egypt from 4 May 2020 March 2022. Participants: 1009 who provided direct patients suspected or confirmed COVID-19....