A5029561426- Meta-analysis and systematic reviews
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Biomedical Text Mining and Ontologies
- Statistical Methods in Clinical Trials
- Pharmaceutical industry and healthcare
- Health and Medical Research Impacts
- Clinical Reasoning and Diagnostic Skills
- Medical Research and Practices
- Delphi Technique in Research
- Medical and Health Sciences Research
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Health Sciences Research and Education
- Biomedical Ethics and Regulation
- Childhood Cancer Survivors' Quality of Life
- Health and Medical Studies
- Prostate Cancer Treatment and Research
- Health Policy Implementation Science
- Vestibular and auditory disorders
- Pharmaceutical studies and practices
- Balance, Gait, and Falls Prevention
- scientometrics and bibliometrics research
- Pharmacological Effects of Natural Compounds
University Medical Center Freiburg
2011-2025
University of Freiburg
2015-2025
Swiss Tropical and Public Health Institute
2022
Careers Europe
2021
Zimmer Biomet (Germany)
2008-2016
University Hospital of Basel
2014
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2007
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
Not all clinical trials are published, which may distort the evidence that is available in literature. We studied publication rate of a cohort and identified factors associated with nonpublication results.We analysed protocols randomized drug interventions submitted to research ethics committee University Hospital (Inselspital) Bern, Switzerland from 1988 1998. full articles published up 2006 by searching Cochrane CENTRAL database (issue 02/2006) contacting investigators. analyzed using...
To investigate the planning of subgroup analyses in protocols randomised controlled trials and agreement with corresponding full journal publications.Cohort trial subsequent publications.Six research ethics committees Switzerland, Germany, Canada.894 involving patients approved by participating between 2000 2003 515 publications.Of 894 trials, 252 (28.2%) included one or more planned analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least analysis, 10 (4.0%) anticipated...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...
To investigate the prevalence of discontinuation and nonpublication surgical versus medical randomized controlled trials (RCTs) to explore risk factors for RCTs.Trial has significant scientific, ethical, economic implications. date, RCTs is unknown.All RCT protocols approved between 2000 2003 by 6 ethics committees in Canada, Germany, Switzerland were screened. Baseline characteristics collected and, if published, full reports retrieved. Risk early slow recruitment explored using...
Background: The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this be possible, studies such as randomized controlled trials (RCTs), which are widely considered provide evidence all forms primary research, must visible and have an impact practice guidelines. We further investigated publicly commercially sponsored RCTs guidelines by measuring direct indirect impactful citations time guideline impact. Methods: sample from...
Abstract Background The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this be possible, studies such as randomized controlled trials (RCTs), which are widely considered provide evidence all forms primary research, must visible and have an impact practice guidelines. We further investigated publicly commercially sponsored RCTs guidelines by measuring direct indirect impactful citations time guideline impact. Methods sample...
Background Many clinical studies are ultimately not fully published in peer-reviewed journals. Underreporting of research is wasteful and can result biased estimates treatment effect or harm, leading to recommendations that inappropriate even dangerous. Methods We assembled a cohort approved 2000–2002 by the Research Ethics Committee University Freiburg, Germany. Published full articles were searched electronic databases investigators contacted. Data on study characteristics extracted from...
<b>Objective</b> To determine whether and how eligibility criteria of participants prespecified in protocols randomised trials are reported subsequent articles. <b>Design</b> Cohort study. <b>Setting</b> Protocols submitted to the ethics committee a German medical faculty. <b>Data sources</b> 52 trial 78 publications published between 2000 2006. <b>Main outcome measure</b> Proportion matching, missing, modified, or newly added publications. <b>Results</b> Differences were found for all...
Only data of published study results are available to the scientific community for further use such as informing future research and synthesis evidence. If reported selectively, reporting bias distortion summarised estimates effect or harm treatments can occur. The publication citation clinical conducted in Germany was studied.The protocols projects submitted ethics committee University Freiburg (Germany) 2000 were analysed. Published full articles several databases searched investigators...
Abstract Background Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility. Other RCTs are early insufficient recruitment. Trial discontinuation has ethical implications, participants consent on the premise contributing to new medical knowledge, Research Ethics Committees (RECs) spend considerable effort reviewing study protocols, and limited resources for conducting research wasted. Currently, little is known regarding frequency...
Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability many to provide informed consent. To assess extent challenges lead randomized trial discontinuation, we compared discontinuation acute nonacute trials.Retrospective cohort 894 approved by six institutional review boards Switzerland, Germany, Canada between 2000 2003.Randomized involving an setting.We recorded...
Financial and other competing interests have recently received increasing attention. In particular clinical research in plastic surgery attracts for-profit organizations, thus, explaining the number of financial sponsorships. However, articles often lack sufficient description study design as well disclosure source funding. Furthermore, debate exists whether industry funding influences findings is leading to pro-industry results. A hand search was conducted identifying all randomized...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Premature discontinuation of clinical studies affects about 25% randomised controlled trials (RCTs) which raises concerns waste scarce resources for research. The risk non-randomised prospective (NPSs) is yet unclear.To compare the proportion discontinued between NPSs and RCTs that received ethical approval.We systematically surveyed longitudinal were approved by a single REC in Freiburg, Germany 2000 2002. We collected study characteristics, identified subsequent publications, investigators...
Background Little is known about publication agreements between industry and academic investigators in trial protocols the consistency of these with corresponding statements publications. We aimed to investigate (i) existence types protocols, (ii) completeness reporting subsequent publications, (iii) frequency co-authorship by employees. Methods Findings used a retrospective cohort randomized clinical trials (RCTs) based on archived approved six research ethics committees 13 January 2000 25...
Although a myriad of original articles is published annually in plastic surgical journals assessment the level evidence-based medicine has rarely been conducted. A hand search was conducted identifying randomized controlled (RCTs) and clinical trials 3 from 1990 to 2005. The quality reporting assessed additional parameters investigated including report statistical significance, type institution, country affiliation first author. Nine thousand four hundred twenty-eight were analyzed which 172...