A5035995410- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Child and Adolescent Health
- RNA regulation and disease
- Statistical Methods in Clinical Trials
- Health and Medical Research Impacts
- Medication Adherence and Compliance
- Retirement, Disability, and Employment
- Colorectal Cancer Treatments and Studies
- Clinical practice guidelines implementation
- Primary Care and Health Outcomes
- scientometrics and bibliometrics research
- Health Literacy and Information Accessibility
- Public Health Policies and Education
- Healthcare cost, quality, practices
- Health and Medical Education
- Parkinson's Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Blood Pressure and Hypertension Studies
- Aging and Gerontology Research
- Aging, Health, and Disability
- Health Policy Implementation Science
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
Instituto de Salud Carlos III
2019-2024
Instituto de Biomedicina de Sevilla
2024
Universidad de Sevilla
2024
Hospital Universitario Virgen del Rocío
2024
Centro de Investigación Biomédica en Red
2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2024
Hospital Universitario Araba
2020-2022
Osakidetza
2022
University Hospital of Basel
2020-2022
University of Basel
2020-2022
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...
Clinical practice guidelines (CPGs) have been developed with the aim of helping health professionals, patients, and caregivers make decisions about their care, using best available evidence. In many cases, incorporation these recommendations into clinical also implies a need for changes in routine practice. Using educational games as strategy implementing among professionals has demonstrated to be effective some studies; however, evidence is still scarce. The primary objective this study...
The preparation of a randomized controlled trial (RCT) requires substantial resources and the administrative processes can be burdensome. To facilitate conduct RCTs it is important to better understand cost drivers. In January 2014 enactment new Swiss Legislation on Human Research (LHR) considerably changed regulatory framework in Switzerland. We assess if LHR was associated with change (i) resource use costs prepare an RCT, (ii) approval times research ethics committees (RECs) authority...
Abstract Background Clearly structured and comprehensive protocols are an essential component to ensure safety of participants, data validity, successful conduct, credibility results randomized clinical trials (RCTs). Funding agencies, research ethics committees (RECs), regulatory medical journals, systematic reviewers, other stakeholders rely on appraise the conduct reporting RCTs. In response evidence poor protocol quality, Standard Protocol Items: Recommendations for Interventional Trials...
To investigate the adherence of randomised controlled trial (RCT) protocols evaluating non-regulated interventions (including dietary interventions, surgical procedures, behavioural and lifestyle exercise programmes) in comparison with regulated to Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 Statement.We conducted a repeated cross-sectional investigation random sample RCT approved 2012 (n = 257) or 2016 292) by research ethics committees Switzerland,...
Purpose Uncertainty exists regarding the best way to communicate cardiovascular risk (CVR) patients, and it is unclear whether comprehension perception of CVR varies according format used. The aim present work was determine a strategy designed for communicating information patients with poorly controlled high blood pressure (HBP), but no background disease, more effective than usual care in control (BP) over course year. Methods A pragmatic, two-arm, cluster-randomized trial performed....
Objectives Comprehensive protocols are key for the planning and conduct of randomised clinical trials (RCTs). Evidence low reporting quality RCT led to publication Standard Protocol Items: Recommendations Interventional Trials (SPIRIT) checklist in 2013. We aimed examine from three countries before after SPIRIT checklist. Design Repeated cross sectional study. Setting Swiss, German Canadian research ethics committees (RECs). Participants approved by RECs 2012 (n=257) 2016 (n=292). Primary...
The purpose of the Core Training Law (CTL) is to amend specialised medical training include 24 months common training. aim this study assess its potential impact on Preventive Medicine and Public Health (PM&PH) programme other specialties.The programmes 21 specialties were analysed recommended periods for each specialty collected, before information was agreed upon by three observers. calculated as percentage that should be amended per adapt schedule.The most affected (100%, months)....
Abstract Background and purpose Parkinson disease (PD) is a complex heterogeneous neurodegenerative disorder with broad spectrum of clinical manifestations, determined by interplay environmental genetic factors. This study aimed to investigate variants associated PD assess their impact on the phenotype through genotype–phenotype correlations. Methods We employed targeted resequencing panel analyze 27 genes linked in cohort 1185 patients from southern Spain. Variants were categorized based...
El desarrollo normativo de la Ley 44/2003, a través del Real Decreto 639/2014, inició el proceso reorganización Formación Sanitaria Especializada (FSE). objetivo este trabajo es elaborar una propuesta competencias específicas para especialidad Medicina Preventiva y Salud Pública mediante un análisis comparado participativo. Cuatro fases: 1) extracción documentación organismos oficiales; 2) consulta dirigida personas clave; 3) abierta residentes implicadas en FSE, 4) difusión Comisión...