A5074510368- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Delphi Technique in Research
- Clinical practice guidelines implementation
- Infection Control and Ventilation
- Healthcare cost, quality, practices
- Pharmaceutical Economics and Policy
- Advanced Causal Inference Techniques
- Economic and Financial Impacts of Cancer
- Health Policy Implementation Science
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Health and Medical Research Impacts
- Diabetes Treatment and Management
- Health Sciences Research and Education
- Blood Pressure and Hypertension Studies
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Inflammasome and immune disorders
- Patient Satisfaction in Healthcare
University of Basel
2016-2025
University Hospital of Basel
2016-2025
Stanford University
2012-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2025
Protein Metrics (United States)
2016-2025
Institute for Medical Informatics and Biostatistics
2024
Laboratory for Biomedical Neurosciences
2024
University of Copenhagen
2023
Innovative Research (United States)
2021-2023
Careers Europe
2021
The aim of this cohort study was to investigate the risk malignant neoplasms and mortality in patients with diabetes treated either human insulin or one three analogues.Data were provided by largest German statutory health insurance fund (time-frame: January 1998 June 2005 inclusive), on without known disease who had received first-time therapy for mellitus exclusively insulin, aspart, lispro glargine. primary outcome diagnosis a neoplasm. Data analysed multiple Cox regression models...
In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness safety of medicines. Currently available guidelines reporting using non-randomised, data—specifically REporting studies Conducted Observational Routinely Data (RECORD) Strengthening Reporting OBservational in Epidemiology (STROBE) statements—do not capture...
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
<b>Objective</b> To assess differences in estimated treatment effects for mortality between observational studies with routinely collected health data (RCD; that are published before trials available) and subsequent evidence from randomized controlled on the same clinical question. <b>Design</b> Meta-epidemiological survey. <b>Data sources</b> PubMed searched up to November 2014. <b>Methods</b> Eligible RCD were 2010 used propensity scores address confounding bias...
Assessing changes in coverage, recall, review, conclusions and references not found when searching fewer databases.In randomly selected 60 Cochrane reviews, we checked included study publications' coverage (indexation) recall (findability) using different search approaches with MEDLINE, Embase, CENTRAL related them to authors' certainty. We assessed characteristics of unfound references.Overall 1989/2080 references, were indexed ≥1 database (coverage = 96%). In reviews where one our would...
Routinely collected data (RCD) are increasingly used for biomedical research. Extensive resources have been invested in this field: they include the set-up of disease registries and clinical databases at regional, national or international levels; promotion use electronic health
Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants eligible for the trial facilitate recruitment, deliver an embedded intervention, collect outcome a combination of these purposes. This report presents Consolidated Standards Reporting Trials (CONSORT) extension randomised data (CONSORT-ROUTINE). The was developed look at...
<h3>Importance</h3> Clinical trial evidence used to support drug approval is typically the only information on benefits and harms that patients clinicians can use for decision-making when novel cancer therapies become available. Various evaluations have raised concern about uncertainty surrounding these data, a systematic investigation of available treatment outcomes drugs approved by US Food Drug Administration (FDA) warranted. <h3>Objective</h3> To describe clinical data at time FDA all...
Importance Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity people MS (MS); however, data on the association between NfL level and have been conflicting. Objective To determine whether when levels elevated context confirmed worsening (CDW). Design, Setting, Participants This study included 2 observational cohorts: results...
Concerns have been raised that regulatory programs to accelerate approval of cancer drugs in may increase uncertainty about benefits and harms for survival quality life (QoL). We analyzed all pivotal clinical trials non-pivotal randomized controlled (RCTs) approved the first time by FDA between 2000 2020. report trial characteristics. Effects on overall (OS), progression-free tumor response were summarized meta-analyses. QoL qualitatively summarized. Between 2020, 145 novel 156 indications...
The state of open science needs to be monitored track changes over time and identify areas create interventions drive improvements. In order monitor practices, they first need well defined operationalized. To reach consensus on what practices at biomedical research institutions, we conducted a modified 3-round Delphi study. Participants were administrators, researchers, specialists in dedicated roles, librarians. rounds 1 2, participants completed an online survey evaluating set potential...
Smoking cessation is challenging, despite making use of established smoking therapies. Preclinical studies and one clinical pilot study suggest the antidiabetic drug glucagon-like peptide-1 (GLP-1) analogue to modulate addictive behaviours nicotine craving. Previously, we reported short-term results a randomised, double-blind, placebo-controlled trial. Herein report long-term abstinence rates weight developments after 24 52 weeks.
Abstract Objective To evaluate the personal protective effects of wearing versus not surgical face masks in public spaces on self-reported respiratory symptoms over a 14 day period. Design Pragmatic randomised superiority trial. Setting Norway. Participants 4647 adults aged ≥18 years: 2371 were assigned to intervention arm and 2276 control arm. Interventions wear mask (eg, shopping centres, streets, transport) period (mask at home or work was mentioned). places. Main outcome measures The...