A5023967301- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Neuroendocrine regulation and behavior
- Pituitary Gland Disorders and Treatments
- Potassium and Related Disorders
- Neuropeptides and Animal Physiology
- Pneumonia and Respiratory Infections
- Pregnancy and preeclampsia studies
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Renal function and acid-base balance
- Smoking Behavior and Cessation
- Gestational Diabetes Research and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
- Pharmacology and Obesity Treatment
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Electroconvulsive Therapy Studies
- Clinical Nutrition and Gastroenterology
- Biomedical and Chemical Research
University Hospital of Basel
2016-2025
University of Basel
2018-2025
Faculty of Media
2023
Hospital Base
2022
University of Cambridge
2021
Cancer Research UK Cambridge Center
2021
Diabetes Australia
2018
The indirect water-deprivation test is the current reference standard for diagnosis of diabetes insipidus. However, it technically cumbersome to administer, and results are often inaccurate. study compared with direct detection plasma copeptin, a precursor-derived surrogate arginine vasopressin.
Significance Statement Treatment options for the syndrome of inappropriate antidiuresis (SIAD), predominant cause hyponatremia, are inadequate. The authors studied effects sodium glucose cotransporter 2 inhibitor empagliflozin, which promotes osmotic diuresis via urinary excretion, in a randomized trial 87 hospitalized patients with SIAD-induced hyponatremia who were also treated standard fluid restriction. Patients received 4 days empagliflozin had significantly larger increase plasma...
Significance Statement The syndrome of inappropriate antidiuresis (SIAD) is a major cause hypotonic hyponatremia. Despite its prevalence, treatment options are sparse, and data on their effect hyponatremia-associated morbidity such as neurocognitive impairment largely lacking. New needed. sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion could be used for chronic SIAD. This randomized, double-blind, placebo-controlled,...
Copeptin derives from the same precursor peptide preprovasopressin as arginine vasopressin (AVP). The secretion of both peptides is stimulated by similar physiological processes, such osmotic stimulation, hypovolemia, or stress. AVP difficult to measure due complex preanalytical requirements and technical difficulties. In last years, copeptin was found be a stable, sensitive, simple surrogate marker release. Different immunoassays exist copeptin. 2 assays which have most often used in...
Distinguishing between arginine vasopressin (AVP) deficiency and primary polydipsia is challenging. Hypertonic saline–stimulated copeptin has been used to diagnose AVP with high accuracy but requires close sodium monitoring. Arginine-stimulated shown similar diagnostic a simpler test protocol. However, data are lacking from head-to-head comparison arginine-stimulated hypertonic in the diagnosis of deficiency. Download PDF Research Summary. In this international, noninferiority trial, we...
Smoking cessation is challenging, despite making use of established smoking therapies. Preclinical studies and one clinical pilot study suggest the antidiabetic drug glucagon-like peptide-1 (GLP-1) analogue to modulate addictive behaviours nicotine craving. Previously, we reported short-term results a randomised, double-blind, placebo-controlled trial. Herein report long-term abstinence rates weight developments after 24 52 weeks.
Copeptin is a stable surrogate marker of vasopressin release; the peptides are stoichiometrically secreted from neurohypophysis due to elevated plasma osmolality or nonosmotic stress. We hypothesized that following stress pituitary surgery, patients with neurohypophyseal damage and eventual diabetes insipidus (DI) would not exhibit expected pronounced copeptin elevation.The objective was evaluate copeptin's accuracy predict DI surgery.This prospective multicenter observational cohort...
Objectives To assess symptoms and characteristics of hyponatremia, the most common electrolyte disturbance in hospitalized individuals a condition that is associated with substantial morbidity mortality. Design Prospective observational multicenter study. Setting Two Swiss academic centers. Participants Individuals profound hypoosmolar hyponatremia (sodium <125 mmol/L) (N = 298). Measurements All complete medical history including current medications, therapy management, in‐hospital...
Hyponatraemia is common and its differential diagnosis challenging. Commonly used diagnostic algorithms have limited accuracy. Copeptin, the c-terminal portion of precursor peptide arginine vasopressin might help in hyponatraemia.Prospective multicentre observational study.A total 298 patients admitted with profound hypoosmolar hyponatraemia (Na < 125 mmol/l) were evaluated. Three experts uninvolved patients' care determined aetiology after standardized evaluation.Hyponatraemia diagnoses as...
BACKGROUNDAlcohol use disorder has a detrimental impact on global health and new treatment targets are needed. Preclinical studies show attenuating effects of glucagon-like peptide-1 (GLP-1) agonists addiction-related behaviors in rodents nonhuman primates. Some trials have shown an effect GLP-1 agonism reward processes humans; however, results from clinical remain inconclusive.METHODSThis is predefined secondary analysis double-blind, randomized, placebo-controlled trial evaluating the...
Background Hyponatremia is the most common electrolyte abnormality in hospitalized patients and given its impact on mortality morbidity, a relevant medical condition. Nevertheless, little known about factors influencing long-term outcome. Methods This prospective observational 12-month follow-up study of with profound hyponatremia (≤125 mmol/L) admitted to emergency department two tertiary care centers between 2011 2013. We analyzed predictive value clinical laboratory parameters regarding...
Abstract Background: The aim was to evaluate the influence of new International Association Diabetes and Pregnancy Study Groups (IADPSG) guidelines for screening gestational diabetes mellitus (GDM) on GDM prevalence in a cohort from Swiss tertiary hospital. Methods: This retrospective study involving all pregnant women who were screened between 24 28 weeks gestation. From 2008 until 2010 (period 1), two-step approach with 1-h 50 g glucose challenge test (GCT) used, followed by fasting, 1-...
Cigarette smoking cessation reduces cardiovascular risk via various mechanisms. Thereby, the role of blood pressure remains unclear, with studies reporting both decreased and increase values after cessation, potentially influenced by weight change. We previously showed that glucagon like peptide-1 analogue dulaglutide mitigates gain cessation. This secondary analysis investigates effect on changes in dulaglutide- vs. placebo-treated individuals. hypothesized a beneficial pressure,...
Abstract Background Fluid restriction ( FR ), the first‐line treatment for hyponatraemia due to syndrome of inappropriate antidiuresis SIAD often does not lead successful correction hyponatraemia. Therefore, predictive markers response are desirable. We evaluated routinely measured serum (s) and urine (u) parameters, s‐copeptin s‐mid‐regional pro‐atrial natriuretic peptide (s‐ MR ‐pro ANP as possible predictors response. Methods In this prospective observational study, we included patients...
Abstract Background Cigarette smoking is the leading preventable cause of premature death. Despite dedicated programmes, quit rates remain low due to barriers such as nicotine withdrawal syndrome or post-cessation weight gain. Glucagon-like peptide-1 (GLP-1) analogues reduce energy intake and body seem modulate addictive behaviour. These GLP-1 properties are major interest in context cessation. The aim this study evaluate analogue dulaglutide a new therapy for Methods This...
Hyponatraemia due to excessive fluid intake (ie primary polydipsia [PP]) is common. It may culminate in profound hyponatraemia-carrying considerable risk of morbidity. However, data on patients with PP leading hyponatraemia are lacking. Herein, we describe the characteristics polydiptic hospitalized and assess 1-year outcomes.Substudy prospective observational Co-MED Study.Patients an episode (≤125 mmol/L) medical emergency were eligible classified into psychogenic (PsyP), dipsogenic (DiP)...