A5016702558- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Neuroendocrine Tumor Research Advances
- Hormonal Regulation and Hypertension
- Neuroendocrine regulation and behavior
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Parathyroid Disorders and Treatments
- Potassium and Related Disorders
- Pituitary Gland Disorders and Treatments
- Biomedical and Chemical Research
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Apelin-related biomedical research
- Diabetes Treatment and Management
- Pneumonia and Respiratory Infections
- Renal function and acid-base balance
- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Intensive Care Unit Cognitive Disorders
- Ion channel regulation and function
- Electroconvulsive Therapy Studies
- Genetic Syndromes and Imprinting
Erasmus MC
2020-2025
University Hospital of Basel
1974-2024
University of Basel
2018-2024
Erasmus University Rotterdam
2021-2024
Erasmus MC Cancer Institute
2022-2023
Cancer Genomics Centre
2022-2023
Faculty of Media
2023
Hospital Base
2022
Diabetes Australia
2018
The indirect water-deprivation test is the current reference standard for diagnosis of diabetes insipidus. However, it technically cumbersome to administer, and results are often inaccurate. study compared with direct detection plasma copeptin, a precursor-derived surrogate arginine vasopressin.
Significance Statement Treatment options for the syndrome of inappropriate antidiuresis (SIAD), predominant cause hyponatremia, are inadequate. The authors studied effects sodium glucose cotransporter 2 inhibitor empagliflozin, which promotes osmotic diuresis via urinary excretion, in a randomized trial 87 hospitalized patients with SIAD-induced hyponatremia who were also treated standard fluid restriction. Patients received 4 days empagliflozin had significantly larger increase plasma...
Significance Statement The syndrome of inappropriate antidiuresis (SIAD) is a major cause hypotonic hyponatremia. Despite its prevalence, treatment options are sparse, and data on their effect hyponatremia-associated morbidity such as neurocognitive impairment largely lacking. New needed. sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion could be used for chronic SIAD. This randomized, double-blind, placebo-controlled,...
Copeptin derives from the same precursor peptide preprovasopressin as arginine vasopressin (AVP). The secretion of both peptides is stimulated by similar physiological processes, such osmotic stimulation, hypovolemia, or stress. AVP difficult to measure due complex preanalytical requirements and technical difficulties. In last years, copeptin was found be a stable, sensitive, simple surrogate marker release. Different immunoassays exist copeptin. 2 assays which have most often used in...
Distinguishing between arginine vasopressin (AVP) deficiency and primary polydipsia is challenging. Hypertonic saline–stimulated copeptin has been used to diagnose AVP with high accuracy but requires close sodium monitoring. Arginine-stimulated shown similar diagnostic a simpler test protocol. However, data are lacking from head-to-head comparison arginine-stimulated hypertonic in the diagnosis of deficiency. Download PDF Research Summary. In this international, noninferiority trial, we...
Insulinomas are hormone-producing pancreatic neuroendocrine neoplasms with an estimated incidence of 1 to 4 cases per million year. Extrapancreatic insulinomas extremely rare. Most present the Whipple triad: (1) symptoms, signs, or both consistent hypoglycemia; (2) a low plasma glucose measured at time symptoms and signs; (3) relief signs when is raised normal. Nonmetastatic nowadays referred as "indolent" metastatic "aggressive." The 5-year survival patients indolent insulinoma has been...
Abstract The aim of this study was to correlate three commercially available copeptin assays and their diagnostic accuracy in the differential diagnosis polyuria-polydipsia syndrome. Analyzed data include repeated measures 8 healthy volunteers 40 patients with syndrome undergoing osmotic stimulation hospitalized pneumonia. Copeptin measured using automated Brahms KRYPTOR, manual LIA Cloud Clone ELISA assay. Primary outcome interrater correlation coefficient (ICC) assays. In volunteers, there...
Hyponatremia often reflects a free water excess. Sodium/glucose cotransporter 2 (SGLT2) inhibitors increase excretion through glucose-induced osmotic diuresis. In randomized double-blind, placebo-controlled trials in patients with the syndrome of inappropriate antidiuresis (SIAD), we showed that empagliflozin increased plasma sodium concentration more effectively than placebo.
Chronic hyponatremia is common and associated with increased morbidity mortality. However, whether treatment improves outcome in patients without significant symptoms unclear. We here assessed the therapeutic on clinical symptoms, neurocognitive neuromuscular function chronic non profound hyponatremia.Prospective case-control study 19 from University Hospital Würzburg clinically apparent symptoms. At baseline after a 14-day period of hyponatremia, were by specific questionnaire, was analysed...
In this multi-centre cohort of 156 patients with hypotonic polyuria, direct measurement hypertonic saline-stimulated plasma copeptin had much greater diagnostic accuracy than a standard water-deprivation test, as judged by the final reference diagnosis, which was determined on basis medical history, test results (with levels masked), and treatment response at 3-month follow-up visit.
Hyponatremia is associated with increased risk for osteoporosis. Preclinical studies in untreated hyponatremia suggest osteoclast upregulation, whereas a clinical study showed improved osteoblast function after normalization hospitalized patients syndrome of inappropriate antidiuresis (SIAD).This work aimed to investigate the effect an increase sodium on bone turnover, that is, ratio marker procollagen type 1 N-terminal propeptide (P1NP) cross-linked C-terminal telopeptide collagen (CTX),...
Abstract Background Empagliflozin increases sodium levels in patients with a chronic syndrome of inappropriate antidiuresis (SIAD), and dapagliflozin apelin diabetes mellitus. Exogenous rats SIAD. We aimed to investigate whether an increase plasma concentration may contribute the efficacy empagliflozin Methods Post hoc secondary analysis double-blind, crossover, placebo-controlled trial performed from December 2017 August 2021 at University Hospital Basel, Switzerland, investigating effect...