A5060720367- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Musculoskeletal pain and rehabilitation
- Muscle activation and electromyography studies
- Older Adults Driving Studies
- Motor Control and Adaptation
- Bone health and osteoporosis research
- Functional Brain Connectivity Studies
- Injury Epidemiology and Prevention
- Frailty in Older Adults
- Health, Medicine and Society
- Dementia and Cognitive Impairment Research
- Electrolyte and hormonal disorders
- Diabetes Treatment and Management
- Aging, Elder Care, and Social Issues
- Medical Practices and Rehabilitation
- Health and Medical Studies
- Hemoglobinopathies and Related Disorders
- Urban Transport and Accessibility
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Iron Metabolism and Disorders
- Scoliosis diagnosis and treatment
Stadtspital Waid
2024
University of Zurich
2024
Felix Platter-Hospital
2013-2023
University of Basel
2009-2023
Group Health Cooperative
2022
Ludwig-Maximilians-Universität München
2015
Rush University Medical Center
2014
University Hospital of Basel
2008-2013
Université d'Angers
2009
University of Geneva
2009
falls and fall-related injuries are common in older adults, have negative effects on functional independence quality of life associated with increased morbidity, mortality health related costs. Current guidelines inconsistent, no up-to-date, globally applicable ones present.
<h3>Objectives:</h3> Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia characterized by slow gait and complaints, in multiple countries, its association with dementia risk. <h3>Methods:</h3> Pooled MCR analysis individual data from 26,802 adults without disability aged 60 years older 22 cohorts 17 countries. We also examined incident impairment (Mini-Mental State Examination decline ≥4 points) associated 4,812 individuals baseline...
The association between low serum 25-hydroxyvitamin D [25(OH)D] concentration and cognitive decline has been investigated by only a few studies, with mixed results. objective of this cross-sectional population-based study was to examine the 25(OH)D deficiency impairment while taking confounders into account.The subjects, 752 women aged > or =75 years from Epidémiologie de l'Ostéoporose (EPIDOS) cohort, were divided 2 groups according concentrations (either deficient, <10 ng/mL, nondeficient,...
Walking is a complex motor task generally performed automatically by healthy adults. Yet, the elderly, walking often no longer automatically. Older adults require more attention for control while than younger Falls, with serious consequences, can be result. Gait impairments are one of biggest risk factors falls. Several studies have identified changes in certain gait parameters as independent predictors fall risk. Such too discrete to detected clinical observation alone. At Basel Mobility...
<i>Background:</i> It has been suggested that high stride-to-stride variability (STV) is a reflection of gait instability. However, both low and STV shown in fallers nonfallers; therefore, the interpretation spatiotemporal parameters remains difficult. Thus, we sought to characterize compare spatial temporal stride among young older healthy adults, determine extent which opposite results could provide similar implications terms stability. <i>Methods:</i> Mean values...
Changes in postural sway and gait patterns due to simultaneously performed cognitive (CI) and/or motor interference (MI) tasks have previously been reported are associated with an increased risk of falling older adults.The objectives this study were investigate the effects a CI MI task on static dynamic control young elderly subjects, find out whether there is association between measures while concurrently performing task.A total 36 healthy (n = 18; age: 22.3 ± 3.0 years; BMI: 21.0 1.6...
Significance Statement The syndrome of inappropriate antidiuresis (SIAD) is a major cause hypotonic hyponatremia. Despite its prevalence, treatment options are sparse, and data on their effect hyponatremia-associated morbidity such as neurocognitive impairment largely lacking. New needed. sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion could be used for chronic SIAD. This randomized, double-blind, placebo-controlled,...
Muscle fatigue and dual-task walking (e.g., concurrent performance of a cognitive interference (CI) while walking) represent major fall risk factors in young older adults. Thus, the objectives this study were to examine effects muscle on gait characteristics under single conditions adults determine impact costs walking.Thirty-two (24.3 ± 1.4 yrs, n = 16) old (71.9 5.5 healthy active participated study. Fatigue knee extensors/flexors was induced by isokinetic contractions. Subjects tested pre...
OBJECTIVES: To investigate dual-task performance of gait and cognition in cognitively healthy impaired older adults using a motor–cognition paradigm. DESIGN: Cross-sectional retrospective study. SETTING: The Basel Memory Clinic the Study on Elderly (Project BASEL). PARTICIPANTS: Seven hundred eleven (mean age 77.2 ± 6.2, 350 (49.2%) female 361 (50.8%) male). MEASUREMENTS: Gait velocity cognitive task working memory (counting backward from 50 by 2s) semantic (enumerating animal names) were...
<b><i>Background:</i></b> Deficits in static and particularly dynamic postural control force production have frequently been associated with an increased risk of falling older adults. <b><i>Objective:</i></b> The objectives this study were to investigate the effects salsa dancing on measures static/dynamic leg extensor power seniors. <b><i>Methods:</i></b> Twenty-eight healthy adults randomly assigned intervention group...
Iron deficiency is associated with increased morbidity and mortality in older adults. However, data on its prevalence incidence among adults limited. The aim of this study was to investigate the iron European community-dwelling aged ≥ 70 years. Secondary analysis DO-HEALTH trial, a 3-year clinical trial including 2157 years from Austria, France, Germany, Portugal Switzerland. defined as soluble transferrin receptor (sTfR) > 28.1 nmol/L. Prevalence rate (IR) per 100 person-years were examined...
Age-related impairment in gait patterns when simultaneously performing cognitive (CI) and/or motor (MI) interference tasks are associated with an increased risk of falling seniors. The objective this study was to investigate the impact balance training (BT) on walking performance and without concurrently a CI MI task Twenty healthy women (n=14) men (n=6) were assigned either intervention (n=11, age 71.9±4.8 yrs) or control group (n=9, 74.9±6.3 yrs). conducted six week BT (3/week). Pre post...
Abstract Introduction In geriatric clinical diagnostics, gait analysis with cognitive‐motor dual tasking is used to predict fall risk and cognitive decline. To date, the neural correlates of processes are not fully understood. investigate these underlying mechanisms, we designed an fMRI paradigm reproduce analysis. Methods We tested paradigm’s feasibility in a substudy fifteen young adults assessed 31 healthy older main study. First, speed variability were quantified using GAITR ite ©...
It was the aim of this study to test insulinotropic actions cholecystokinin octapeptide (CCK-8), gastric inhibitory polypeptide (GIP), and glucagon-like peptide I (GLP-I)-(7--36) amide at basal glucose but physiologically elevated amino acid concentrations. Therefore, in nine fasting healthy volunteers, an mixture infused intravenously (12.6 g/h over 120 min). On separate occasions, from 30 min, placebo (0.9% NaCl-1% human serum albumin), synthetic sulfated CCK-8 (0.5 pmol.kg-1.min-1), GIP...